DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm2 and Kdm7a

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_001028602.2	Gene:	Kdm7a / 338523	MGIID:	2443388	Length:	940	Species:	Mus musculus

Alignment Length:	649	Identity:	193/649 - (29%)
Similarity:	302/649 - (46%)	Gaps:	161/649 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RKQRKLYLEEWSLGDEDGE----GTRGFSVAEKLESSKFAQAG-MVREMRGCDLTVAFLQQHGFN 106
            :|:|..:..:::..|:..:    |||.|  .::|.|..|..|. ::.:|.|..||..:|::|||:
Mouse    95 KKRRNWHRHDYTEVDDGSKPVQAGTRAF--VKELRSRVFPSADEIIVKMHGSQLTQRYLEKHGFD 157

  Fly   107 IPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQYYDSPQKDR 171
            :|::......||||:|.| .|:|.||...||..:::||:||..|.:.:||:..:.:|:.:|.:.:
Mouse   158 VPIMVPKLDDLGLRLPSP-AFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPDRPK 221

  Fly   172 LLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPK--VQKYCLM 234
            :|||||||||.|::...|:.|:|.|::.||:..||..              .::||  |||||||
Mouse   222 VLNVISLEFSDTKMSELVEVPDIARKLSWVENYWPDD--------------SVFPKPFVQKYCLM 272

  Fly   235 SVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDTVEKCAR 299
            .|::.||||||||||||||||:|.|.|:|:||.||:.||.|||.|..|..|:::||||.|:||.:
Mouse   273 GVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTNENLALYESWSSSVTQSEVFFGDKVDKCYK 337

  Fly   300 VYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRYPFFTEM 364
            ..:..|:|.|:||||||||.|....:.|||||||:..|..||:...:|...|.|..|::|||..:
Mouse   338 CVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAI 402

  Fly   365 LWYVLARYVHTLLGHSHLEGEASLSEDEMAARPHTHL--------THHELFGLKEIVM-YLYDLP 420
            .|:|....:.||         ..|.||  ..:|.::|        |..:|:..||:|. :.:::|
Mouse   403 CWFVAKSLLETL---------KELKED--GFQPQSYLVQGVKALHTALKLWMKKELVSEHAFEIP 456

  Fly   421 PQKKNVPSLVLDPVALIKD----VRSLVERHCKDQQDLAITGVSVLKSPPG-SQPPFLLYDRTRV 480
            ...:        |..|||:    :|::.|.:.|..:...|..|..:..|.. :.||:  :.|.::
Mouse   457 DNVR--------PGHLIKELSKVIRAIEEENGKPVKSQGIPSVCPVSRPSNEASPPY--HSRRKM 511

  Fly   481 KQ---------------EI-KQEIARK-------------------------------------- 491
            ::               |: .:|:.::
Mouse   512 RKLRDHNVRTPSNLDILELHTREVLKRLEMCPWEEDLLSSKLNGKFNKHLQPSSTVPEWRAKDND 576

  Fly   492 ------NAEVIREQQQLEAGRA-----REAESDTSQSTGVGSVIGMGAGVEYSNGVMKKEQLENG 545
                  |..:|::::||.|.|:     .|.|.|...:               .|..||.||....
Mouse   577 LRLLLTNGRIIKDERQLFADRSLYTADSENEEDKKPT---------------QNANMKTEQSSGR 626

  Fly   546 SGVTVGGHGSQPEATFALPTDTLKYRPPK-----------------KMHLATALVAAAASSSSG 592
            ......|........|......|:.||.:                 |::.||     ..|.|||
Mouse   627 EEAESQGSPKPLNRIFTSVRSELRSRPSEYSDGSDSEDSGPDCTALKINFAT-----EDSESSG 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367	59/99 (60%)
		PRTases_typeI	<394..>467	CDD:294217	18/85 (21%)
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689
		leucine-rich repeat	1102..1125	CDD:275381
		leucine-rich repeat	1126..1149	CDD:275381
		leucine-rich repeat	1150..1173	CDD:275381
		AMN1	1166..>1320	CDD:187754
		leucine-rich repeat	1174..1213	CDD:275381
		leucine-rich repeat	1214..1238	CDD:275381
		leucine-rich repeat	1239..1267	CDD:275381
		leucine-rich repeat	1268..1292	CDD:275381
		leucine-rich repeat	1293..1317	CDD:275381
Kdm7a	NP_001028602.2	PHD_KDM7	39..88	CDD:277110
		Linker. /evidence=ECO:0000250	97..114		2/16 (13%)
		JmjC	234..297	CDD:214721	35/76 (46%)
		cupin_like	269..369	CDD:304367	59/99 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..509		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	599..670		13/85 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..729
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..854
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..920
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1633
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000253
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810