DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and CG15056

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_573291.1	Gene:	CG15056 / 32824	FlyBaseID:	FBgn0030918	Length:	399	Species:	Drosophila melanogaster

Alignment Length:	223	Identity:	39/223 - (17%)
Similarity:	75/223 - (33%)	Gaps:	85/223 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1076 YLPQDTLVTC-------CSVCKVWSNAAVDPDLWKKMNCSEHKMS--ASLLTAIVRRQPEHLI-- 1129
            ::.:|.::.|       .|:|              .:|..|:::.  ..|.:.:::......|
  Fly   220 HIYRDLVLACPLLVMVEISIC--------------SLNRDEYRLGELRYLQSLVIKAHSTDTIRC 270

  Fly  1130 --LDWTQIAKRQLAWLVARLPALKNLSLQNCPIQAVLALHTCLCPPLQTLDLSFVRGLNDAAIRD 1192
              .||..|:       :..:|.|:||...:.|                       .|...|....
  Fly   271 KVSDWMLIS-------LLDVPFLRNLMFSDAP-----------------------SGFVSANALS 305

  Fly  1193 ILSPPKDSRPGLSDSKTRLRDLKVMKLAG-----TDISDVAVRYITQSLPYLRHLDLSSCQRITD 1252
            |:|              |.|.|:|:|:..     .|:..:      ::|.:|..||||:...||:
  Fly   306 IIS--------------RFRQLRVLKMPNQPYRPNDLLRL------RNLTFLETLDLSNSPYITN 350

  Fly  1253 AGVAQIGTSTTATARLTELNLSACRLVS 1280
            ..|.::   ......|:.|.:..|.|::
  Fly   351 EVVIEL---VIGIPNLSVLIVQGCPLLT 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689	5/38 (13%)
		leucine-rich repeat	1102..1125	CDD:275381	3/24 (13%)
		leucine-rich repeat	1126..1149	CDD:275381	4/26 (15%)
		leucine-rich repeat	1150..1173	CDD:275381	4/22 (18%)
		AMN1	1166..>1320	CDD:187754	23/120 (19%)
		leucine-rich repeat	1174..1213	CDD:275381	5/38 (13%)
		leucine-rich repeat	1214..1238	CDD:275381	5/28 (18%)
		leucine-rich repeat	1239..1267	CDD:275381	8/27 (30%)
		leucine-rich repeat	1268..1292	CDD:275381	4/13 (31%)
		leucine-rich repeat	1293..1317	CDD:275381
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381
		leucine-rich repeat	157..179	CDD:275381
		leucine-rich repeat	180..204	CDD:275381
		leucine-rich repeat	205..231	CDD:275381	2/10 (20%)
		leucine-rich repeat	232..285	CDD:275381	9/73 (12%)
		leucine-rich repeat	286..326	CDD:275381	13/76 (17%)
		AMN1	306..>376	CDD:187754	21/93 (23%)
		leucine-rich repeat	337..362	CDD:275381	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900