DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and fbxl6

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_001296447.1	Gene:	fbxl6 / 323163	ZFINID:	ZDB-GENE-060810-162	Length:	564	Species:	Danio rerio

Alignment Length:	262	Identity:	59/262 - (22%)
Similarity:	98/262 - (37%)	Gaps:	81/262 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1061 QNLALDPTVLKIIFRY-LPQDTLV-TCC---SVCKVWSNAAVDPDLWKKMN---CSEHKMSASLL 1117
            |:|.|:  :|..||:: :.||..| ..|   .||::|:.||..|.||:.::   |
Zfish   146 QSLPLE--ILVKIFQFAVFQDGAVPLLCRVGRVCRLWNGAASSPILWRSVSIGYC---------- 198

  Fly  1118 TAIVRRQPEHLILDWTQIAKRQLA-----------WLVA-RLPALKNLSLQNC----PIQAVLAL 1166
                          |.:..|.||.           ||.. ||..|:..||  |    .:..|:..
Zfish   199 --------------WIEPGKSQLPGTEQKIKNTVDWLAENRLFQLREFSL--CHWKKNVDYVIQK 247

  Fly  1167 HTCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKV------MKLAGTDIS 1225
            .:..|..|.:|.||:..|:.:.|.:::.:..:    .|.|...:..::.|      ::..|..|.
Zfish   248 VSQSCLSLHSLKLSYCTGMTEKAFQNLGADCQ----SLEDINVQHSEINVDGLVSFLEAYGNQIK 308

  Fly  1226 DVAVRYITQSLPYLRHLDLSSCQRI--------TDAGVA---------QIGTSTTATARLTELNL 1273
            .:...:.|:|...|..|....|..:        .|.|.:         |||.....|.||  :|:
Zfish   309 KIYFTHSTKSDKLLSALSKGCCPELRLLEINTKLDGGYSQLPICIQGLQIGCPKLQTFRL--MNV 371

  Fly  1274 SA 1275
            :|
Zfish   372 TA 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689	14/42 (33%)
		leucine-rich repeat	1102..1125	CDD:275381	2/25 (8%)
		leucine-rich repeat	1126..1149	CDD:275381	8/34 (24%)
		leucine-rich repeat	1150..1173	CDD:275381	6/26 (23%)
		AMN1	1166..>1320	CDD:187754	27/133 (20%)
		leucine-rich repeat	1174..1213	CDD:275381	8/38 (21%)
		leucine-rich repeat	1214..1238	CDD:275381	5/29 (17%)
		leucine-rich repeat	1239..1267	CDD:275381	9/44 (20%)
		leucine-rich repeat	1268..1292	CDD:275381	3/8 (38%)
		leucine-rich repeat	1293..1317	CDD:275381
fbxl6	NP_001296447.1	F-box-like	147..195	CDD:289689	17/49 (35%)
		AMN1	213..396	CDD:187754	36/169 (21%)
		leucine-rich repeat	229..254	CDD:275381	6/26 (23%)
		leucine-rich repeat	255..280	CDD:275381	6/28 (21%)
		leucine-rich repeat	281..306	CDD:275381	4/24 (17%)
		leucine-rich repeat	307..334	CDD:275381	6/26 (23%)
		leucine-rich repeat	335..362	CDD:275381	5/26 (19%)
		AMN1	<391..>542	CDD:187754
		leucine-rich repeat	391..418	CDD:275381
		leucine-rich repeat	419..438	CDD:275381
		leucine-rich repeat	445..473	CDD:275381
		leucine-rich repeat	475..505	CDD:275381
		leucine-rich repeat	506..530	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900