DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm2 and Phf8

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_001106825.1	Gene:	Phf8 / 320595	MGIID:	2444341	Length:	1023	Species:	Mus musculus

Alignment Length:	1105	Identity:	289/1105 - (26%)
Similarity:	419/1105 - (37%)	Gaps:	295/1105 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LEEWSLGDED------GEGTRGFSVAEKLESS------------KFAQAGMVREMR--------- 91
            :||....|.|      .|...|.|:.:|...|            |...:..:||:|
Mouse    37 VEEEKAADIDLYHCPNCEVLHGPSIMKKRRGSSKGHDNHKGKPLKTGSSMFIRELRGRTFDSSDE 101

  Fly    92 ------GCDLTVAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQ 150
                  |..|||.||:::.|::|:|...|.|||:.:|.| .|||.||...|||.:.:||:||..|
Mouse   102 VILKPTGSQLTVEFLEENSFSVPILVLKKDGLGMTLPSP-SFTVRDVEHYVGSDKEIDVIDVARQ 165

  Fly   151 KNLQMTMKEWQQYYDSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQRE 215
            .:.:|.:.::.:||.|.:::::|||||||||.|||...|::|.|||::.||:.:||::....:
Mouse   166 ADCKMKLGDFVKYYYSGKREKVLNVISLEFSDTRLSNLVETPRIVRKLSWVENLWPEECVFER-- 228

  Fly   216 GTNLLGGMMYPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWV 280
                      |.|||||||||::.||||||||||||||||:|:|.|:|:||.||:.||.|:|.|.
Mouse   229 ----------PNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWS 283

  Fly   281 LSGKQADIFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTAS 345
            .|..|.::||||.||||.:..:..|.|.||||||||||.||...|.||||||||..|..|||...
Mouse   284 SSSNQNEMFFGDQVEKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYE 348

  Fly   346 VEDSTKVPQKFRYPFFTEMLWYVLARYVHTLLGHSHLEGEASLSEDEMAARPHTHLTH------- 403
            :|........|::|.|..:.|||         |...|:....|.|:.  ..|.::|.|
Mouse   349 IEKRLSTADLFKFPNFETICWYV---------GKHILDIFRGLRENR--RHPASYLVHGGKALNL 402

  Fly   404 -HELFGLKEIVMYLYDLPPQKKNVPSLVLDPVALIKDVRSLVERHCKD--QQDLA----ITGVSV 461
             ...:..||.      ||..:..:|..| ..|.||||:...: |..:|  ||::.    |.|:..
Mouse   403 AFRAWTKKEA------LPDHEDEIPETV-RTVQLIKDLAREI-RLVEDIFQQNVGKTSNIFGLQR 459

  Fly   462 LKSPPGSQPPFLLYDRTRVKQEIKQEIARKNAEVIREQQQLEAGRAREAESDTSQSTGVGSVIGM 526
            : .|.||.|.......|.|... |..:..||....:..:..:..:..|.:...|.:.|....:..
Mouse   460 I-FPAGSIPLTKPAHSTSVSMS-KLSLPSKNGSKKKGLKPKDIFKKAERKGKQSSALGPAGQLSY 522

  Fly   527 GAGVEYSNGVMKKEQLENGSGVTVGGHGSQPEATFALPTDTLKYRPPKKMHLATALVAAAASSSS 591
            .....||:..:|.              |...:|.|.:...:|......          :|.....
Mouse   523 NLMDPYSHQALKT--------------GPSQKAKFNMSGTSLNDSDDD----------SADMDLD 563

  Fly   592 GGGGPVAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEGGQVGG----ILNMDNCH 652
            |...|:|.:..:   ||:..     :..|:.:..|.......|:.:...||.|    :.:.|...
Mouse   564 GSENPLALLMAN---GSTKR-----MKSVSKSRRAKIAKKVDSARLVAEQVMGDEFDLDSDDELQ 620

  Fly   653 SPEGGGAKLSPNLTGTGQPRRRRTRCKNCAACQR-SDCGTCPF---------------------- 694
            ..|..| |...||....:..|:..|.|.|:...| .:.|...|
Mouse   621 IDERLG-KEKANLLIRSKFPRKLPRAKPCSDPNRIREPGEVEFDIEEDYTTDEDMVEGVESKLGN 684

  Fly   695 ------CMDMVK----FGGPGRAKQT----------------CMMRQCLSPMLPVTAQCVYCHLD 733
                  .:|::|    .|||..|..|                ||.....|...|.|:.     |.
Mouse   685 GSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQEAIQGMLCMANLQSSSSSPATSS-----LQ 744

  Fly   734 GW-------------------RQTPVSPQT------------------KQLASADGPSALMECSV 761
            .|                   ..:|.|.:|                  ::.||.|...:|..|..
Mouse   745 AWWTGGQERSSGSSSSGLGTVSSSPASQRTPGKRPIKRPAYWKNESEEEENASLDEQDSLGACFK 809

  Fly   762 CYEIAHPDCALSQLDGTEDAADAKGIVNEDLPNSWECPSCCRSGKNYDYKPRHFRAR------QK 820
            ..|..:|     .|:..:|....|              |..:..||.|..|...:||      ::
Mouse   810 DAEYIYP-----SLESDDDDPALK--------------SRPKKKKNSDDAPWSPKARVTPTLPKQ 855

  Fly   821 SSEVRR----VSVSHGQGGAEGHADGNTLLPPPVGQYNDFVFTSESEMESGTVSGHMTHWKHGMK 881
            ...||.    .|:..|...|...                   .::.|::.....      |:..|
Mouse   856 DRPVREGTRVASIETGLAAAAAK-------------------LAQQELQKAQKK------KYIKK 895

  Fly   882 RHHQLEVKTER----NNSCDTPSPGI--SPNAIGGDSKVGKRRKSDDGTSVSSSMHESNDAPCGS 940
            :....||:..|    |.....|:|.:  :|......|.........:..|.|.:.||....|
Mouse   896 KPLLKEVEQPRPQDSNPIMTMPAPTVATTPQPDTSSSPQPPPEPKQEALSGSLADHEYTARP--- 957

  Fly   941 SAEGAGGAGNANVSTNQWS---------------GSGGGGGSRKKNSIRSQLAQQMLNSSTRVLK 990
               .|.|...||.||...:               .|..|.|.|.|..:.:  |:|.|.   |:||
Mouse   958 ---NAFGMAQANRSTTPMAPGVFLTQRRPSVGSQSSQAGQGKRPKKGLAT--AKQRLG---RILK 1014

Fly 991 990
Mouse 1015 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367	63/99 (64%)
		PRTases_typeI	<394..>467	CDD:294217	21/86 (24%)
		zf-CXXC	670..716	CDD:251032	16/94 (17%)
		PHD_4	721..801	CDD:293471	17/116 (15%)
		F-box-like	<1073..1108	CDD:289689
		leucine-rich repeat	1102..1125	CDD:275381
		leucine-rich repeat	1126..1149	CDD:275381
		leucine-rich repeat	1150..1173	CDD:275381
		AMN1	1166..>1320	CDD:187754
		leucine-rich repeat	1174..1213	CDD:275381
		leucine-rich repeat	1214..1238	CDD:275381
		leucine-rich repeat	1239..1267	CDD:275381
		leucine-rich repeat	1268..1292	CDD:275381
		leucine-rich repeat	1293..1317	CDD:275381
Phf8	NP_001106825.1	PHD_PHF8	6..57	CDD:277112	5/19 (26%)
		Linker. /evidence=ECO:0000250	65..79		1/13 (8%)
		JmjC	199..262	CDD:214721	38/74 (51%)
		cupin_like	234..334	CDD:389752	63/99 (64%)
		JHD	338..441	CDD:375347	30/121 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..497		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..561		6/50 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..803		11/75 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..865		13/68 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..1009		29/164 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1633
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000253
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810