DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm2 and Fbxl19

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	XP_006230338.1	Gene:	Fbxl19 / 308999	RGDID:	1310989	Length:	739	Species:	Rattus norvegicus

Alignment Length:	749	Identity:	216/749 - (28%)
Similarity:	321/749 - (42%)	Gaps:	181/749 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   659 AKLSPNLTGTGQ-----PRRRRTRCKNCAACQRSDCGTCPFCMDMVKFGGPGRAKQTCMMRQCLS 718
            |.|:|.::.:.:     .|||||||:.|.||.|::||.|.||.||.|||||||.||:|::|||.:
  Rat    60 ALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTA 124

  Fly   719 PMLPVTAQCVYCHLDGWRQTPVSPQTKQLASADGPSALMECSVCYEIAHPDCALSQLDGTEDAAD 783
            |:||.||.|:.|...|...|....:.|...|      ||||::|.||.||.|.        ....
  Rat   125 PVLPHTAVCLLCGEAGKEDTVEGEEEKFSLS------LMECTICNEIVHPGCL--------KMGK 175

  Fly   784 AKGIVNEDLPNSWECPSCCRSGKNYDYKPRHFRARQKSSEVRRVSVSHGQGGAEGHADGN----- 843
            |:|::|.::||.||||.|.:.|                    |.|...|:|.....||..
  Rat   176 AEGVINSEIPNCWECPRCTQEG--------------------RTSKDAGEGPGRRRADNGEEGAN 220

  Fly   844 -------TLLPP------------PVGQYNDFV--FTSESEMESGT--------VSGHMTHWKHG 879
                   |..||            |.|...|.|  .....|.|.|.        |.|       |
  Rat   221 LGGGWKLTEEPPPPPPLPRRKGPLPAGPPPDDVPGPPKRKEREGGNEPPTPRKKVKG-------G 278

  Fly   880 MKRHHQLEVKTERNNSC-----DTPSPGISPNAIGGDSKVGKRRKSDDGTSVSSSMHE------- 932
            .:||    :|....::|     |..|||:.|..:...|:            ..||.|.
  Rat   279 RERH----LKKVGGDACLLRGADPGSPGLLPPRVLNPSQ------------AFSSCHPGLPPENW 327

  Fly   933 SNDAPCGSSAEGAGGAGNANVSTNQWSGSGGGGGSRKKNSIRSQLAQQMLNSSTRVLKKPQYVVR 997
            ....|..:||||.                          ::.|...|:   ......|:...::.
  Rat   328 EKPKPPIASAEGP--------------------------AVPSPSPQR---EKLERFKRMCQLLE 363

  Fly   998 PASGTGSSSSSGNGGSASATNGISN----GSNQSGANSCGAGNGERGTNNGG----LSGSNG--- 1051
            ....|.||||..:..|.|:...:|.    |..::|.......:||: .|.||    ..||.|
  Rat   364 RVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEK-ENRGGRRAIRPGSGGPLL 427

  Fly  1052 ---LG----------NQHYSSSQNLALDPTVLKI---------------IFRYLPQDTLVTCCSV 1088
               ||          .:|.......:.:|..|.:               :|::|....|..|..|
  Rat   428 SWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCVCMRV 492

  Fly  1089 CKVWSNAAVDPDLWKKMNCSEHK-MSASLLTAIVRRQPEHLILDWTQIAKRQLAWLVARLPALKN 1152
            |:.||....|..||.:|:.|..| ::..:|:.:|||||..|.|.||.::|:||.||:.||..|:.
  Rat   493 CRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQE 557

  Fly  1153 LSLQNCPIQAVLALHTCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVM 1217
            |.|..|...:|.||.:...|.|:.|||.::..:.|:.:|::|.||.|::||.::|:.||:.:..:
  Rat   558 LVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAEL 622

  Fly  1218 KLAGTDISDVAVRYITQSLPYLRHLDLSSCQRITDAGVAQIGTSTTATAR--LTELNLSACRLVS 1280
            :|||.:::|.::|.:.:..|.|..||||.|..:.|..| .:.|:.|:..|  |..|||:.|..::
  Rat   623 RLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSV-HLLTAPTSPLRETLVHLNLAGCHRLT 686

  Fly  1281 ENALEHLAKCEGLIWLDLRHVPQVSTQSVIRFAS 1314
            ::.|....:|..|..||||...|:|.::..|.|:
  Rat   687 DHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAA 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032	29/50 (58%)
		PHD_4	721..801	CDD:293471	29/79 (37%)
		F-box-like	<1073..1108	CDD:289689	12/34 (35%)
		leucine-rich repeat	1102..1125	CDD:275381	8/23 (35%)
		leucine-rich repeat	1126..1149	CDD:275381	11/22 (50%)
		leucine-rich repeat	1150..1173	CDD:275381	7/22 (32%)
		AMN1	1166..>1320	CDD:187754	50/151 (33%)
		leucine-rich repeat	1174..1213	CDD:275381	15/38 (39%)
		leucine-rich repeat	1214..1238	CDD:275381	5/23 (22%)
		leucine-rich repeat	1239..1267	CDD:275381	10/27 (37%)
		leucine-rich repeat	1268..1292	CDD:275381	7/23 (30%)
		leucine-rich repeat	1293..1317	CDD:275381	9/22 (41%)
Fbxl19	XP_006230338.1	zf-CXXC	<95..122	CDD:251032	18/26 (69%)
		PHD_FXL19	132..193	CDD:277115	25/74 (34%)
		F-box-like	469..512	CDD:289689	12/42 (29%)
		AMN1	511..710	CDD:187754	71/199 (36%)
		leucine-rich repeat	531..554	CDD:275381	11/22 (50%)
		leucine-rich repeat	555..578	CDD:275381	7/22 (32%)
		leucine-rich repeat	616..643	CDD:275381	6/26 (23%)
		leucine-rich repeat	644..670	CDD:275381	10/26 (38%)
		leucine-rich repeat	674..698	CDD:275381	7/23 (30%)
		leucine-rich repeat	699..723	CDD:275381	9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5292
eggNOG	1	0.900	-	-		E1_KOG1633
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D165446at33208
OrthoFinder	1	1.000	-	-		FOG0000253
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820