DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kdm2 and Kdm2b

DIOPT Version :10

Sequence 1:NP_649864.2 Gene:Kdm2 / 41090 FlyBaseID:FBgn0037659 Length:1345 Species:Drosophila melanogaster
Sequence 2:XP_011246510.1 Gene:Kdm2b / 30841 MGIID:1354737 Length:1312 Species:Mus musculus


Alignment Length:1533 Identity:478/1533 - (31%)
Similarity:654/1533 - (42%) Gaps:513/1533 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 RQLRERKQRKLYLEEWSLGD-EDGEGTRGFSVAEKLESSKFAQAGMVREMRGCDLTVAFLQQHGF 105
            |:|| ...|:.|.|...|.| |:....||||:.|||.|..: |...|..|.|.|....::|:...
Mouse     9 RRLR-AIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLY-QGDFVHAMEGKDFNYEYVQREAL 71

  Fly   106 NIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQYYDSP--Q 168
            .:||:||||.|||::|||| :|||.||:|.||||||:|||||||||..:|:|.::.:||::|  |
Mouse    72 RVPLVFRDKDGLGIKMPDP-DFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQ 135

  Fly   169 KDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPKVQKYCL 233
            :|:|.||||||||||:|:..|:.|.:|..:||||.:||:.||:.|.|.||.|..|.||||:||||
Mouse   136 RDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNALAEMKYPKVKKYCL 200

  Fly   234 MSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDTVEKCA 298
            ||||.|:|||||||||||||||:.||.|:|||||||..||.|||:|||||||:|||.||.||:|.
Mouse   201 MSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQ 265

  Fly   299 RVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRYPFFTE 363
            |:.|..|.|||||:|||||||||..|||||||.||||.:..||:...:||.|:|..||||||:.|
Mouse   266 RIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYE 330

  Fly   364 MLWYVLARYVHTLLGHSHL---------------------------------------------- 382
            |.||||.|||:.:...|:|                                              
Mouse   331 MCWYVLERYVYCVTQRSYLTQEYQRELMLIDAPRKTSVDGFSSDSWLDMEEESCEQQPQEEEEEE 395

  Fly   383 -----EGEAS-------------------LSEDEMAARPH------------------------- 398
                 ||:.:                   ..:|....:|.                         
Mouse   396 EDKEEEGDGADKTPKPPTDDPTSPTSTPPEDQDSTGKKPKAPAIRFLKRTLSNESEESVKSTSMP 460

  Fly   399 -------------------THLTHHELFGLKEIVMYLYDLPPQKKNVPSLVLDPVALIKDVRSLV 444
                               ||||..||.|||.:|..|..||..||.||..:.||.||::.|::::
Mouse   461 TDDPKTPTGSPATEVSTKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVL 525

  Fly   445 ERHCKDQQDLAITGVSVLKSPPGSQPPFLLYDRTRVKQEIKQEIARKNAEVIREQQQLEAGRARE 509
            :.|..|...||||||.|:..|                                            
Mouse   526 KEHVDDDPTLAITGVPVVSWP-------------------------------------------- 546

  Fly   510 AESDTSQSTGVGSVIGMGAGVEYSNGVMKKEQLENGSGVTVGGHGSQPEATFALPTDTLKYRPPK 574
                  :.|....|:|                                             ||..
Mouse   547 ------KKTAKNRVVG---------------------------------------------RPKG 560

  Fly   575 KMHLATALVAAAASSSSGGGGPVAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEG 639
            |:                  ||.:.|                                       
Mouse   561 KL------------------GPASAV--------------------------------------- 568

  Fly   640 GQVGGILNMDNCHSPEGGGAKLSPNLTGTGQPRRRRTRCKNCAACQRSDCGTCPFCMDMVKFGGP 704
                                ||:.|.|..| .|||||||:.|.||.|::||.|.||.||.|||||
Mouse   569 --------------------KLAANRTTAG-ARRRRTRCRKCEACLRTECGECHFCKDMKKFGGP 612

  Fly   705 GRAKQTCMMRQCLSPMLPVTAQCVYCHLDGWRQTPVSPQTK-QLASADGPSALMECSVCYEIAHP 768
            ||.||:|:||||::|:||.||.|:.|...|...|....:.| .|       .|||||:|.||.||
Mouse   613 GRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNL-------MLMECSICNEIIHP 670

  Fly   769 DCALSQLDGTEDAADAKGIVNEDLPNSWECPSCCRSGK--------------------------- 806
            .|.        ...:::|:||::|||.||||.|..:||                           
Mouse   671 GCL--------KIKESEGVVNDELPNCWECPKCNHAGKTGKAYKQKRGPGFKYASNLPGSLLKEQ 727

  Fly   807 --NYDYK-----------------------PRHFRA----RQKSSEV-----------------R 825
              |.|.|                       |:...|    |:||.:|                 :
Mouse   728 KMNRDNKEGQEPAKRRSECEEAPRRRSDEHPKKVPADGILRRKSDDVHLRRKRKYEKPQELSGRK 792

  Fly   826 RVSVSHGQGGAEGHADGNTLLP-PPVGQ-----YNDFVFTSESEMESG----TVSGHMTHWKHG- 879
            |.|......|:..|     |.| ||:|.     :...:...:.:::.|    ........||:. 
Mouse   793 RASSLQTSPGSSSH-----LSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAE 852

  Fly   880 ---------MKRHHQ--------LEVKTERNNSCDTPSPGISPNAIGGD-----SKVGKRRK--- 919
                     ::|..|        ...||..::...:.||...|:..|.:     .||..|||   
Mouse   853 DRLSLANKPLRRFKQEPEDDLPEAPPKTRESDQSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRL 917

  Fly   920 --------------SDDGTSVSSSMHESNDAPCGSSAEGAGGAGNANVS----TNQWSGSGGGGG 966
                          .:...:.|:..|||.. |..|..|.........:|    .:::| .|..|.
Mouse   918 VNKELSKELSKELNHEIQKTESTLAHESQQ-PIKSEPESENDEPKRPLSHCERPHRFS-KGLNGT 980

  Fly   967 SRKKNSIRSQLAQQMLNSSTRVLKKP-------------QYVVRPASGTGSSSSSGNGGSASATN 1018
            .|:   :|..|... |.|..||:.:|             ::|:||...:....|           
Mouse   981 PRE---LRHSLGPG-LRSPPRVMSRPPPSASPPKCIQMERHVIRPPPISPPPDS----------- 1030

  Fly  1019 GISNGSNQSGANSCGAGNGERGTNNGGLSGSNGLGNQHYSSSQNLALDPTVLKIIFRYLPQDTLV 1083
                                       |...:|..:         .:...|...:|.||....|.
Mouse  1031 ---------------------------LPLDDGAAH---------VMHREVWMAVFSYLSHRDLC 1059

  Fly  1084 TCCSVCKVWSNAAVDPDLWKKMNCSEHK-MSASLLTAIVRRQPEHLILDWTQIAKRQLAWLVARL 1147
            .|..||:.|:....|..||.:::.:..| ::..:|:.|:||||..|.|.||.|:|:||:||:.||
Mouse  1060 VCMRVCRTWNRWCCDKRLWTRIDLNRCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRL 1124

  Fly  1148 PALKNLSLQNCPIQAVLALHTCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLR 1212
            |.|::|.|..|...||.||.:..||.|:|||:.:|.||.||.:||:||||.|:|||..|::::||
Mouse  1125 PGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLR 1189

  Fly  1213 DLKVMKLAGTDISDVAVRYITQSLPYLRHLDLSSCQRITDAGV---AQIGTSTTATARLTELNLS 1274
            ::..::|||.||:||::|.|.:.:|.|..|.||.|..|.|..:   ..:||:|..:  |||:|||
Mouse  1190 NIVELRLAGLDITDVSLRLIIRHMPLLSKLQLSYCNHINDQSINLLTAVGTTTRDS--LTEVNLS 1252

  Fly  1275 ACRLVSENALEHLAKCEGLIWLDLRHVPQVSTQSVIRF 1312
            .|..|::..|....:|..:..:|||:..||:.:...:|
Mouse  1253 DCNKVTDLCLSFFKRCGNICHIDLRYCKQVTKEGCEQF 1290

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kdm2NP_649864.2 cupin_RmlC-like 231..331 CDD:477354 76/99 (77%)
CTD_Jhd1-like 399..465 CDD:412024 31/65 (48%)
zf-CXXC 670..716 CDD:366873 30/45 (67%)
PHD_4 721..802 CDD:465288 31/81 (38%)
F-box-like <1073..1105 CDD:463757 11/31 (35%)
leucine-rich repeat 1102..1125 CDD:275381 6/23 (26%)
leucine-rich repeat 1126..1149 CDD:275381 12/22 (55%)
leucine-rich repeat 1150..1173 CDD:275381 9/22 (41%)
AMN1 1166..>1320 CDD:187754 61/150 (41%)
leucine-rich repeat 1174..1213 CDD:275381 21/38 (55%)
leucine-rich repeat 1214..1238 CDD:275381 9/23 (39%)
leucine-rich repeat 1239..1267 CDD:275381 10/30 (33%)
leucine-rich repeat 1268..1292 CDD:275381 10/23 (43%)
leucine-rich repeat 1293..1317 CDD:275381 6/20 (30%)
Kdm2bXP_011246510.1 JmjC 151..226 CDD:214721 46/74 (62%)
cupin_RmlC-like 198..304 CDD:477354 81/105 (77%)
JHD 303..>338 CDD:465515 18/34 (53%)
CTD_KDM2B 480..546 CDD:412026 31/65 (48%)
zf-CXXC <588..624 CDD:366873 23/35 (66%)
PHD_KDM2B 634..695 CDD:277114 27/75 (36%)
PTZ00449 <693..995 CDD:185628 53/312 (17%)
F-box_FBXL10 1036..1080 CDD:438951 13/52 (25%)
leucine-rich repeat 1053..1075 CDD:275381 6/21 (29%)
leucine-rich repeat 1078..1102 CDD:275381 6/23 (26%)
AMN1 1083..1283 CDD:187754 86/201 (43%)
leucine-rich repeat 1103..1126 CDD:275381 12/22 (55%)
leucine-rich repeat 1127..1150 CDD:275381 9/22 (41%)
leucine-rich repeat 1151..1190 CDD:275381 21/38 (55%)
leucine-rich repeat 1191..1215 CDD:275381 9/23 (39%)
leucine-rich repeat 1216..1245 CDD:275381 10/28 (36%)
leucine-rich repeat 1246..1270 CDD:275381 10/23 (43%)
leucine-rich repeat 1271..1295 CDD:275381 6/20 (30%)

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