DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm2 and Phf2

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	XP_038951595.1	Gene:	Phf2 / 306814	RGDID:	1305228	Length:	1096	Species:	Rattus norvegicus

Alignment Length:	1166	Identity:	282/1166 - (24%)
Similarity:	427/1166 - (36%)	Gaps:	326/1166 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 NNNGNGNLSPNAKGVQRRQLRERKQRKLYLEEWSLGDEDGEGTRGFSVAEKLESSKFAQA-GMVR 88
            :.:|.|. :|:.|.||...       :|:::|                   |.|..|..| .:|.
  Rat    69 HKHGPGQ-TPDMKPVQNGS-------QLFIKE-------------------LRSRTFPSAEDVVS 106

  Fly    89 EMRGCDLTVAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNL 153
            .:.|..|||.::::|||..|:|...|.||||.:|.| .|.|:||...||..|.:||.||..||:.
  Rat   107 RVPGSQLTVGYMEEHGFTEPILVPKKDGLGLAVPAP-TFYVSDVENYVGPERSVDVTDVTKQKDC 170

  Fly   154 QMTMKEWQQYYDSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTN 218
            :|.:||:..||.|..:.|:|||.:||||.||:..||:.|:||:::.||:..||.....|:
  Rat   171 KMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAK----- 230

  Fly   219 LLGGMMYPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSG 283
                   |||.||||:.||:.|||||||.||.|.|||:|:|.|:|:||.|...||.|||.|..:.
  Rat   231 -------PKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIRPASANLSLYECWRSAS 288

  Fly   284 KQADIFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVED 348
            ..:::||.|.|:||.:..:..|.|.|||:|||:|..||...|.|.|:||||..:..|::...||.
  Rat   289 NHSEMFFADQVDKCYKCTVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVER 353

  Fly   349 STKVPQKFRYPFFTEMLWYVLARYVHTLLGHSHLEGE-----------------ASLSEDEMAAR 396
            ..|:....::|.|....||:....:....| ||..|:                 .|.::.:..|.
  Rat   354 RLKLGSLTQFPNFETACWYMGKHLLEAFKG-SHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAE 417

  Fly   397 PHTHLTHHELFGLKEIVMYLYDLPPQKKNVPSLV---LDPVALIKDV------------------ 440
            ....|..|  |...:::..|.......:|....|   ::.||...:|
  Rat   418 HEDELPEH--FRPSQLIKDLAKEIRLSENASKTVRPEVNAVASSDEVCDGDREKEEPPSPIESTP 480

  Fly   441 -RSLVERHCKDQQDLAITGVSVLKSPPGSQPP-----FLLYDRTRVKQE---------------- 483
             |||:|:..|.:....:......|:|...:||     ..|.|.::.|.:
  Rat   481 PRSLLEKVSKKKTSKTVKMPKPSKTPKPPKPPKPPKTLKLKDGSKKKGKKCKESASPTIPNLDLL 545

  Fly   484 --------IKQEIARK-----------NAEVIREQQQLEAGRAREAESDTSQSTGVGSVIGMGAG 529
                    .|.|..:|           |.:.:..|..:|....||.....|:           |.
  Rat   546 EAHTKEALTKMEPPKKGKTPKSVLSVPNKDTVHTQNDVERLEIREQTKSKSE-----------AK 599

  Fly   530 VEYSNGV------MKKEQLENGSGVTVGGHGSQPEATFALPTDTL----KYRPPKKMHLATALVA 584
            .:|.|..      |::||....|.:.    |::.:.:|:.....|    ..|||
  Rat   600 WKYKNSKPDSLLRMEEEQRLEKSPLA----GNKDKFSFSFSNRKLLGSKPLRPP----------- 649

  Fly   585 AAASSSSGGGGPVAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEGGQVGGILNMD 649
                ||.|            |.|:..|.......||          .....|:..   .|.|.:|
  Rat   650 ----SSPG------------VFGTLQSFKEDKAKPV----------RDEYEYVSD---DGELKID 685

  Fly   650 NC------HSPEGGGA----KLSPNLTGTGQPRRRRTRCKNCAACQRS----DCGTCPFCMDMVK 700
            ..      :.|:...:    |....|..|.:|:...|..|:..:....    |..|.|.....||
  Rat   686 EFPIRRKKNPPKRDLSFLLDKKETLLIPTSKPKLDSTAYKSDDSSDEGSLHIDTDTKPSRNAKVK 750

  Fly   701 FGGPGRAKQTCMMRQCLSPMLPVTAQCVYCHLDGWRQTPVSPQTKQLASADGPSALMECSVCYEI 765
                   |::......:..:|..:.:......:...|.|.||.|::........|.::.|
  Rat   751 -------KESGSSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQAS----- 803

  Fly   766 AHPDCALSQLDGT--------------EDAADAKGIVNEDLPNSWECPSCCRSGKN----YDYKP 812
               |..|....||              ::...:||.....|.         |:.||    .||:.
  Rat   804 ---DSCLQTTWGTGQAKGGSLAAHGARKNGGSSKGTGKRLLK---------RTAKNSVDLEDYEE 856

  Fly   813 R-HFRARQKSSEVRRVSVSHGQGGAEGHADGNTLLPPPVGQYNDFVFTSESEMESGTVSGHMTHW 876
            : |..|..|.|                                |:|:.|....|...|      :
  Rat   857 QDHLDACFKDS--------------------------------DYVYPSLESDEDNPV------F 883

  Fly   877 KHGMKRHHQLEVKTERNNSCDTPSPGISPNAIGGDSKVGKRRKSDDGTSVSSSMHESNDAPCGSS 941
            |...|:         |..|.|.|   .||.|..|.|...:.|...:||.|             :|
  Rat   884 KSRSKK---------RKGSDDAP---YSPTARVGPSVPRQDRPVREGTRV-------------AS 923

  Fly   942 AEGAGGAGNANVSTNQWSGSGGGGGSRKKNSIRSQLAQQMLNSSTRVLKKPQYVVRPASGTGSSS 1006
            .|....|..|.:|..:...:     .:|||:.|         ..|.....|......::.||::|
  Rat   924 IETGLAAAAAKLSQQEEQKN-----RKKKNTKR---------KPTPNTASPSVSTSASASTGTTS 974

  Fly  1007 SSGNGGS---ASATNGISNGSNQSGANSCGAGNGERGTNNGGLSGSNGLGNQHYSSSQNLA 1064
            :|....|   ||.|...:..::.|.|:|..:..|. .......|.|:||.:..|:::...|
  Rat   975 ASTTPASTTPASTTPASTTPASTSTASSQASQEGS-SPEPPPESHSSGLADHEYTAAGTFA 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367	51/99 (52%)
		PRTases_typeI	<394..>467	CDD:294217	17/94 (18%)
		zf-CXXC	670..716	CDD:251032	9/49 (18%)
		PHD_4	721..801	CDD:293471	15/93 (16%)
		F-box-like	<1073..1108	CDD:289689
		leucine-rich repeat	1102..1125	CDD:275381
		leucine-rich repeat	1126..1149	CDD:275381
		leucine-rich repeat	1150..1173	CDD:275381
		AMN1	1166..>1320	CDD:187754
		leucine-rich repeat	1174..1213	CDD:275381
		leucine-rich repeat	1214..1238	CDD:275381
		leucine-rich repeat	1239..1267	CDD:275381
		leucine-rich repeat	1268..1292	CDD:275381
		leucine-rich repeat	1293..1317	CDD:275381
Phf2	XP_038951595.1	PHD_PHF2_like	7..53	CDD:277029
		JmjC	201..264	CDD:214721	34/74 (46%)
		cupin_RmlC-like	236..336	CDD:424065	51/99 (52%)
		JHD	340..443	CDD:407680	18/105 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347456
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1633
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000253
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740