DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and Fbxo39

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_001034107.1	Gene:	Fbxo39 / 303287	RGDID:	1311464	Length:	443	Species:	Rattus norvegicus

Alignment Length:	321	Identity:	65/321 - (20%)
Similarity:	111/321 - (34%)	Gaps:	90/321 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1065 LDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVDPDLWK-----------KMNCSEHKMSASLLT 1118
            |....|:.:|.:|..........||:.|:......|||:           :::.||.: ||....
  Rat    19 LPDVCLRRVFWWLGDRDRSRAALVCRKWNQIMYSADLWRYRTITFSGRPSRVHASEFE-SALWYV 82

  Fly  1119 AIVRRQPEHLILDWT-----------QIAKRQLAWLVARL-PALKNLSLQNCPIQAVLALHTCLC 1171
            ....|..|||.:.:.           |:..|.|...:.:. ..|::||:|:..:..::..::
  Rat    83 KKFGRYLEHLEIKFLNPYNAVLTKKFQVTMRGLLSCLGKSNNRLRSLSIQHLELDRLVWRNS--- 144

  Fly  1172 PPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLAGTDISDVAVRYITQSL 1236
                      :||....::...|             |...:.|..:.|.|..::.....:|..||
  Rat   145 ----------IRGSLIKSLSFFL-------------KKMGKHLDHLSLKGARLTVEQGCHILNSL 186

  Fly  1237 PYLRHLDLSSCQRITD---AGVAQIGTSTTATARLTELNLSACRL----VSENALEHLA------ 1288
            .|:|:.:::|...|.|   ..:|..|:|....|..|..||:...|    :|:..||.|:
  Rat   187 SYMRNENVASELNIEDFFSHHLAVYGSSQFNKAMATFHNLTFLTLNYNCISDELLETLSENNAGT 251

  Fly  1289 ------KCE----------GLIWLDLRHVPQVSTQSVIRFASNSKHDLCVRDIKLVERRRR 1333
                  ||.          |:.|..|           .|.|||.|.:.....:...||..|
  Rat   252 LRTMNIKCHVHDPHGQVVWGMSWAKL-----------ARQASNLKVNFFFERVMKYERLAR 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689	8/45 (18%)
		leucine-rich repeat	1102..1125	CDD:275381	6/33 (18%)
		leucine-rich repeat	1126..1149	CDD:275381	6/34 (18%)
		leucine-rich repeat	1150..1173	CDD:275381	4/22 (18%)
		AMN1	1166..>1320	CDD:187754	37/182 (20%)
		leucine-rich repeat	1174..1213	CDD:275381	4/38 (11%)
		leucine-rich repeat	1214..1238	CDD:275381	6/23 (26%)
		leucine-rich repeat	1239..1267	CDD:275381	7/30 (23%)
		leucine-rich repeat	1268..1292	CDD:275381	10/49 (20%)
		leucine-rich repeat	1293..1317	CDD:275381	6/23 (26%)
Fbxo39	NP_001034107.1	F-box-like	16..57	CDD:403981	9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900