DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and epe1

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_588188.1	Gene:	epe1 / 2539481	PomBaseID:	SPCC622.16c	Length:	948	Species:	Schizosaccharomyces pombe

Alignment Length:	510	Identity:	141/510 - (27%)
Similarity:	229/510 - (44%)	Gaps:	95/510 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 EKLESSKFAQAGMVREMRGCDLTVAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGS 138
            ::|....|.|.|. |.|....:..::.:..|||.|.:|........|     :..::.:...:|.
pombe   139 QRLLGMSFPQDGF-RRMPAESVNFSYFRDTGFNEPTIFPSSDTQNTR-----QLNLSKIATLIGY 197

  Fly   139 RRLLDVMDVNTQKNL--QMTMKEWQQY--YDSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQID 199
            ...|.::||.|||.:  :|.|:.|.:|  .:..::.|:.:|:|||.|.|:|..:|:.|.|||.:|
pombe   198 DCPLALVDVVTQKQIPNKMDMESWVKYMSLEPSKRGRIYDVLSLEVSTTKLAYYVRKPNIVRDLD 262

  Fly   200 WVDVVWPKQLKDAQREGTNLLGGMMYPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFW 264
            .|:.|||        .|:..||  .||.|..|||||.:|.||:|||:|||:|.:|:||.|.|:|:
pombe   263 LVNTVWP--------PGSFALG--EYPHVDTYCLMSAENSYTEFHIEFGGSSAYYNILDGCKIFY 317

  Fly   265 LIPPTDRNLQLYEKWVLSGKQAD-IFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFG 328
            |||.|.:|.:.|..|:.|...:| .|..:.|:.|..|.:.:..|..:|:|||:||.||..::...
pombe   318 LIPGTSKNWEAYTAWLTSSNDSDKKFLPNMVDVCYCVEVHSQQTILVPSGWIYAVVTPCDTISIA 382

  Fly   329 GNFLHSFGIVKQLKTASVEDSTKVPQKFRYPFFTEMLWYVLARYVHTLLGHSHLEGEASLSEDEM 393
            ||||....|..||...::|....:.::::||:|..::||....:......:|..:|     .|::
pombe   383 GNFLTFLHIYPQLSIYNLELQLGIEKEYQYPYFESIMWYTAIHFYLAFPDNSSRDG-----IDDI 442

  Fly   394 AARPHT-------HLTHHELFGLKEIVMYLYDLPPQKKNVPSLVLDPVALIKDVRSLVERHCKDQ 451
            .|...|       ..|..||.|.:|::.|||                      :|:.:.|.|...
pombe   443 IAEYETGRLFDINAFTEQELDGFEELLNYLY----------------------IRAQILRDCDII 485

  Fly   452 QDLAITGVSVLK-----SPPGSQPPFLLYDRTRVKQEIKQEIARK------------------NA 493
            .|:....|.:.|     |.....||.|        .||..:..:|                  |.
pombe   486 IDIYNEPVKISKNNGYNSAYTMVPPDL--------DEICVDFVQKFGAWITYHHRRSAKHPSCNC 542

  Fly   494 EVIREQQQLEAGRAREAESDTSQSTGVGSVIGMGAGVEYSNGVMKK---EQLENG 545
            ....:.:.:::|......|...||..:|.||..      ::.::||   .|::.|
pombe   543 FSHLQTKLIDSGPKPANNSYQHQSNFIGVVIST------NHNIIKKCQESQIQTG 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367	44/100 (44%)
		PRTases_typeI	<394..>467	CDD:294217	17/84 (20%)
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689
		leucine-rich repeat	1102..1125	CDD:275381
		leucine-rich repeat	1126..1149	CDD:275381
		leucine-rich repeat	1150..1173	CDD:275381
		AMN1	1166..>1320	CDD:187754
		leucine-rich repeat	1174..1213	CDD:275381
		leucine-rich repeat	1214..1238	CDD:275381
		leucine-rich repeat	1239..1267	CDD:275381
		leucine-rich repeat	1268..1292	CDD:275381
		leucine-rich repeat	1293..1317	CDD:275381
epe1	NP_588188.1	cupin_like	284..385	CDD:304367	44/100 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	93	1.000	Domainoid score	I1996
eggNOG	1	0.900	-	-		E1_KOG1633
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000253
OrthoInspector	1	1.000	-	-		oto101006
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23123
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R626
SonicParanoid	1	1.000	-	-		X1005
TreeFam	1	0.960	-	-
	9	8.900