DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and FBXL7

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_036436.1	Gene:	FBXL7 / 23194	HGNCID:	13604	Length:	491	Species:	Homo sapiens

Alignment Length:	421	Identity:	96/421 - (22%)
Similarity:	169/421 - (40%)	Gaps:	96/421 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   944 GAGGAGNANVSTNQWSGSGGGGGSRKKN---SIRSQLAQQMLNSSTRVLKKPQYVVRPASGTGSS 1005
            |:.|.|::::|::..|.:.......:||   |..|.|:.:.|::.:..|..|..:....:|.|||
Human    10 GSEGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSS 74

  Fly  1006 SSSGN-GGSASA----------TNGISNGSNQSGANSCGAGNGERGTNNGGLSGSNGLGNQHYSS 1059
            :||.: .|...|          |:.:...:::.                           |...:
Human    75 TSSSSITGETVAMVHSPPPTRLTHPLIRLASRP---------------------------QKEQA 112

  Fly  1060 SQNLALDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVDPDLWKKMNCSEHKMSASLLTAIVRRQ 1124
            |.:...|.:::: ||.:||.:.|..|..||:.|.|.|.||.||:.:..:...::......::.|:
Human   113 SIDRLPDHSMVQ-IFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRR 176

  Fly  1125 PEHLILDWTQIAKRQLAWLVARLPALKNLSLQNCPIQAVLALHT---CLCPPLQTLDLSFVRGLN 1186
               |..|...:..           .|:.:::..|.......|:|   | ||.|:.|::|....::
Human   177 ---LCQDTPNVCL-----------MLETVTVSGCRRLTDRGLYTIAQC-CPELRRLEVSGCYNIS 226

  Fly  1187 DAAIRDILSPPKDSRPGLSD------------SKTRLRDLKVMKLAGTDIS-------------D 1226
            :.|:.|::|    ..|.|..            |.||...:|:..|.|..||             |
Human   227 NEAVFDVVS----LCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLED 287

  Fly  1227 VAVRYITQSLPYLRHLDLSSCQRITDAGVAQIGTSTTATARLTELNLSACRLVSENALEHLAKCE 1291
            ..:..|......|.||.|..|.|:||.|:..:   ....|.:.||::|.||.||:..|..:||.|
Human   288 EGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYL---VIYCASIKELSVSDCRFVSDFGLREIAKLE 349

  Fly  1292 G-LIWLDLRH---VPQVSTQSVIRFASNSKH 1318
            . |.:|.:.|   |..|..:.|.::.|..::
Human   350 SRLRYLSIAHCGRVTDVGIRYVAKYCSKLRY 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689	15/34 (44%)
		leucine-rich repeat	1102..1125	CDD:275381	2/22 (9%)
		leucine-rich repeat	1126..1149	CDD:275381	2/22 (9%)
		leucine-rich repeat	1150..1173	CDD:275381	6/25 (24%)
		AMN1	1166..>1320	CDD:187754	51/185 (28%)
		leucine-rich repeat	1174..1213	CDD:275381	11/50 (22%)
		leucine-rich repeat	1214..1238	CDD:275381	7/36 (19%)
		leucine-rich repeat	1239..1267	CDD:275381	9/27 (33%)
		leucine-rich repeat	1268..1292	CDD:275381	10/23 (43%)
		leucine-rich repeat	1293..1317	CDD:275381	7/26 (27%)
FBXL7	NP_036436.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79		19/68 (28%)
		F-box-like	114..157	CDD:372399	16/43 (37%)
		leucine-rich repeat	129..151	CDD:275381	9/21 (43%)
		leucine-rich repeat	154..187	CDD:275381	4/46 (9%)
		LRR 1	170..195		4/38 (11%)
		AMN1	<185..366	CDD:187754	50/199 (25%)
		leucine-rich repeat	188..213	CDD:275381	6/25 (24%)
		LRR 2	196..221		8/25 (32%)
		leucine-rich repeat	214..234	CDD:275381	5/19 (26%)
		LRR 3	222..247		5/28 (18%)
		leucine-rich repeat	240..273	CDD:275381	7/32 (22%)
		LRR 4	253..281		8/27 (30%)
		leucine-rich repeat	274..299	CDD:275381	2/24 (8%)
		LRR 5	282..307		6/24 (25%)
		AMN1	297..464	CDD:187754	28/87 (32%)
		leucine-rich repeat	300..325	CDD:275381	9/27 (33%)
		LRR 6	308..333		8/27 (30%)
		leucine-rich repeat	326..351	CDD:275381	11/24 (46%)
		LRR 7	334..359		10/24 (42%)
		leucine-rich repeat	352..377	CDD:275381	6/24 (25%)
		LRR 8	360..385		4/21 (19%)
		leucine-rich repeat	378..403	CDD:275381	0/3 (0%)
		LRR 9	386..411
		leucine-rich repeat	404..429	CDD:275381
		LRR 10	412..437
		leucine-rich repeat	430..453	CDD:275381
		LRR 11	438..463
		leucine-rich repeat	456..480	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810