DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kdm2 and Kdm2a

DIOPT Version :10

Sequence 1:NP_649864.2 Gene:Kdm2 / 41090 FlyBaseID:FBgn0037659 Length:1345 Species:Drosophila melanogaster
Sequence 2:NP_001001984.2 Gene:Kdm2a / 225876 MGIID:1354736 Length:1161 Species:Mus musculus


Alignment Length:1405 Identity:468/1405 - (33%)
Similarity:640/1405 - (45%) Gaps:352/1405 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 LSPNAKGVQRRQLRERKQRKLYLEEWSLGDEDGEGTRGFSVAEKLESSKFAQAGMVREMRGCDLT 96
            :.|..:.::..|......|:.| |:..:.|::.||.|.|.:.|||:::|: .|..|..|.|.|..
Mouse     1 MEPEEERIRYSQRLRGTMRRRY-EDDGISDDEIEGKRTFDLEEKLQTNKY-NANFVTFMEGKDFN 63

  Fly    97 VAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQ 161
            |.::|:.|...||:|::..|||::|||| :||||||::||||||::|||||||||.::|||.:|.
Mouse    64 VEYIQRGGLRDPLIFKNSDGLGIKMPDP-DFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWT 127

  Fly   162 QYYDSPQKDR--LLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMM 224
            :||::|:::|  |.||||||||||||:..||.|..|..|||||.:||:.||::|.|.||.:..|.
Mouse   128 RYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQ 192

  Fly   225 YPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIF 289
            ||||||||||||:.||||||:|||||||||||.:|.|||||||||..||:|||.|:|||||.|||
Mouse   193 YPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIF 257

  Fly   290 FGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQ 354
            .||.|..|.|:.|..|.||.||:||||||||||.:|||||||||||.|..|||..|:||.|:||.
Mouse   258 LGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPN 322

  Fly   355 KFRYPFFTEMLWYVLARYVHTLLGHSHL----------------EGEASLSEDEMAARP------ 397
            ||||||:.||.||||.|||:.:...|||                |.|:...::|...|.      
Mouse   323 KFRYPFYYEMCWYVLERYVYCITNRSHLTKDFQKESLSMDMELNELESGNGDEEGVDREARRMNN 387

  Fly   398 --------------------------------------------------------------HTH 400
                                                                          ..|
Mouse   388 KRSVLTSPVANGVNLDYDGLGKACRSLPSLKKTLSGDSSSDSTRGSHNGQVWDPQCSPKKDRQVH 452

  Fly   401 LTHHELFGLKEIVMYLYDLPPQKKNVPSLVLDPVALIKDVRSLVERHCKDQQDLAITGVSVLKSP 465
            |||.||.||:.:|..|..||..||.||:.:.|..|||.||:.|:|........||:|||.:::.|
Mouse   453 LTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELASSDPKLALTGVPIVQWP 517

  Fly   466 PGSQPPFLLYDRTRVKQEIKQEIARKNAEVIREQQQLEAGRAREAESDTSQSTGVGSVIGMGAGV 530
            ...:..|....:.||                                                  
Mouse   518 KRDKLKFPTRPKVRV-------------------------------------------------- 532

  Fly   531 EYSNGVMKKEQLENGSGVTVGGHGSQPEATFALPTDTLKYRPPKKMHLATALVAAAASSSSGGGG 595
                                               .|:....|..|..|..|.            
Mouse   533 -----------------------------------PTIPITKPHTMKPAPRLT------------ 550

  Fly   596 PVAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEGGQVGGILNMDNCHSPEGGGAK 660
            ||.....|.:              |:||                                     
Mouse   551 PVRPAAASPI--------------VSGA------------------------------------- 564

  Fly   661 LSPNLTGTGQPRRRRTRCKNCAACQRSDCGTCPFCMDMVKFGGPGRAKQTCMMRQCLSPMLPVTA 725
                       ||||.||:.|.||.:.:||.|.:|.||.|||||||.||:|::||||:|.||.:.
Mouse   565 -----------RRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSV 618

  Fly   726 QCVYC-HLDGWRQTPVSPQTKQLASADGPSALMECSVCYEIAHPDCALSQLDGTEDAADAKGIVN 789
            .|..| .:|...:|           .|....||||.:|.||.||.|.  |:||       :|::|
Mouse   619 TCSLCGEVDQNEET-----------QDFEKKLMECCICNEIVHPGCL--QMDG-------EGLLN 663

  Fly   790 EDLPNSWECPSCCRSGKNYDYKPRHFRARQKSSEVRRVSVSHGQGGAEGHADGNTLLPPPVGQYN 854
            |:|||.||||.|.:...:...:.|  :..:...|..:..|.......|     ..|.|||...  
Mouse   664 EELPNCWECPKCYQEDSSDKAQKR--KIEESDEEAVQAKVLRPLRSCE-----EPLTPPPHSP-- 719

  Fly   855 DFVFTSESEMESGTVS--GHMTHWKHGMKRHHQLEVKTERNNSCDTPSPGISP---NAIGGDSKV 914
                ||..::....||  |.:|.                       .|||..|   ::...|.:.
Mouse   720 ----TSMLQLIHDPVSPRGMVTR-----------------------SSPGAGPSDHHSASRDERF 757

  Fly   915 GKRRKSDDGTSVSSSMHESNDAPCG----SSAEGAGGAGNANVSTNQWSGSGGGGGSRKKNSIRS 975
            .:|:......:..:.:.|..:.|.|    |..|.|...|:....|.|.......|     .||..
Mouse   758 KRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHG-----TSIVP 817

  Fly   976 QLAQQMLNSSTRVLKKPQYVVR--PASGTGSSSSSGNGGSASATNGISNGSNQSGANSCGAGNGE 1038
            :| |.:..||..:...|:.:::  ||.........|.||......               ....:
Mouse   818 KL-QAITASSANLRPNPRVLMQHCPARNPQHGDEEGLGGEEEEEE---------------EEEED 866

  Fly  1039 RGTNNGGLSGSNGLGNQHYSSSQNLALDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVDPDLWK 1103
            .....||.:..||.|:......::. :...|...:||||.:..|..|..|||.|.....|..||.
Mouse   867 DSAEEGGAARLNGRGSWAQDGDESW-MQREVWMSVFRYLSRKELCECMRVCKTWYKWCCDKRLWT 930

  Fly  1104 KMNCSEHK-MSASLLTAIVRRQPEHLILDWTQIAKRQLAWLVARLPALKNLSLQNCPIQAVLALH 1167
            |::.|..| :....|:.|::|||..|.|.||.|:|:||.|||.|||.||:|.|..|...||.||.
Mouse   931 KIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALS 995

  Fly  1168 TCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLAGTDISDVAVRYI 1232
            |..||.|:||||.:..|:.|..|||:|:||.| :|| .|::::||::...:|||.||:|..:|.|
Mouse   996 TSSCPLLRTLDLRWAVGIKDPQIRDLLTPPTD-KPG-QDNRSKLRNMTDFRLAGLDITDATLRLI 1058

  Fly  1233 TQSLPYLRHLDLSSCQRITDAG---VAQIGTSTTATARLTELNLSACRLVSENALEHLAKCEGLI 1294
            .:.:|.|..||||.|..:||..   :..:|:||..:  |||||::.|..:::..|..|.:...:.
Mouse  1059 IRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYS--LTELNMAGCNKLTDQTLFFLRRIANVT 1121

  Fly  1295 WLDLRHVPQVSTQSVIRFAS----NSKHDLCVRDIKLVER 1330
            .:|||...|::.::...|.|    ||.:  |:.|.||:::
Mouse  1122 LIDLRGCKQITRKACEHFISDLSINSLY--CLSDEKLIQK 1159

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kdm2NP_649864.2 cupin_RmlC-like 231..331 CDD:477354 73/99 (74%)
CTD_Jhd1-like 399..465 CDD:412024 29/65 (45%)
zf-CXXC 670..716 CDD:366873 26/45 (58%)
PHD_4 721..802 CDD:465288 30/81 (37%)
F-box-like <1073..1105 CDD:463757 13/31 (42%)
leucine-rich repeat 1102..1125 CDD:275381 7/23 (30%)
leucine-rich repeat 1126..1149 CDD:275381 13/22 (59%)
leucine-rich repeat 1150..1173 CDD:275381 11/22 (50%)
AMN1 1166..>1320 CDD:187754 59/160 (37%)
leucine-rich repeat 1174..1213 CDD:275381 18/38 (47%)
leucine-rich repeat 1214..1238 CDD:275381 8/23 (35%)
leucine-rich repeat 1239..1267 CDD:275381 11/30 (37%)
leucine-rich repeat 1268..1292 CDD:275381 8/23 (35%)
leucine-rich repeat 1293..1317 CDD:275381 7/27 (26%)
Kdm2aNP_001001984.2 cupin_RmlC-like 199..299 CDD:477354 73/99 (74%)
JHD 304..>339 CDD:465515 22/34 (65%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 419..445 0/25 (0%)
CTD_KDM2A 450..517 CDD:412025 29/66 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..557 8/121 (7%)
zf-CXXC <576..609 CDD:366873 19/32 (59%)
PHD_KDM2A 619..675 CDD:277113 28/75 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 705..789 21/117 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 840..886 10/60 (17%)
F-box_FBXL11 885..931 CDD:438952 14/46 (30%)
leucine-rich repeat 929..953 CDD:275381 7/23 (30%)
AMN1 931..1137 CDD:187754 85/209 (41%)
leucine-rich repeat 954..977 CDD:275381 13/22 (59%)
LRR 1 960..981 14/20 (70%)
leucine-rich repeat 978..1001 CDD:275381 11/22 (50%)
LRR 2 983..1009 14/25 (56%)
leucine-rich repeat 1002..1039 CDD:275381 18/38 (47%)
leucine-rich repeat 1040..1064 CDD:275381 8/23 (35%)
LRR 3 1047..1072 11/24 (46%)
leucine-rich repeat 1065..1094 CDD:275381 11/28 (39%)
LRR 4 1073..1102 11/30 (37%)
leucine-rich repeat 1095..1119 CDD:275381 8/23 (35%)
LRR 5 1103..1127 5/23 (22%)
leucine-rich repeat 1120..1139 CDD:275381 4/18 (22%)
LRR 6 1128..1155 7/28 (25%)

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