DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm2 and Phf2

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	NP_035208.2	Gene:	Phf2 / 18676	MGIID:	1338034	Length:	1096	Species:	Mus musculus

Alignment Length:	1203	Identity:	280/1203 - (23%)
Similarity:	428/1203 - (35%)	Gaps:	377/1203 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SPNAKGVQRRQLRERKQRKLYLEEWSLGDEDGEGTRGFSVAEKLESSKFAQA-GMVREMRGCDLT 96
            :|:.|.||...       :|:::|                   |.|..|..| .:|..:.|..||
Mouse    76 TPDVKPVQNGS-------QLFIKE-------------------LRSRTFPSAEDVVSRVPGSQLT 114

  Fly    97 VAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQ 161
            |.::::|||..|:|...|.||||.:|.| .|.|:||...||..|.:||.||..||:.:|.:||:.
Mouse   115 VGYMEEHGFTEPILVPKKDGLGLAVPAP-TFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFV 178

  Fly   162 QYYDSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYP 226
            .||.|..:.|:|||.:||||.||:..||:.|:||:::.||:..||.....|:            |
Mouse   179 DYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAK------------P 231

  Fly   227 KVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFG 291
            ||.||||:.||:.|||||||.||.|.|||:|:|.|:|:||.|...|:.|||:|..:...:::||.
Mouse   232 KVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIRPASANISLYERWRSASNHSEMFFA 296

  Fly   292 DTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKF 356
            |.|::|.:..:..|.|.|||:|||:|..||...|.|.|:||||..:..|::...||...|:....
Mouse   297 DQVDRCYKCTVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLT 361

  Fly   357 RYPFFTEMLWYVLARYVHTLLGHSHLEGE-----------------ASLSEDEMAARPHTHLTHH 404
            ::|.|....||:....:....| ||..|:                 .|.::.:..|.....|..|
Mouse   362 QFPNFETACWYMGKHLLEAFKG-SHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEH 425

  Fly   405 ELFGLKEIVMYLYDL--------------------------------------------PPQ--- 422
              |...:::.   ||                                            ||:
Mouse   426 --FRPSQLIK---DLAKEIRLSENASKTVRPEVNAAASSDEVCDGDREKEEPPSPVETTPPRSLL 485

  Fly   423 ----KKNV--------PSLVLDP--------VALIKDVRSLVERHCKDQQDLAITGVSVLKS--- 464
                ||..        ||.:..|        ...:||......:.||:.....|..:.:|::
Mouse   486 EKVSKKKTSKTVKMPKPSKIPKPPKSPKPPKTLKLKDGSKKKGKKCKESASPTIPNLDLLEAHTK 550

  Fly   465 -------PP--GSQPPFLL-------------------YDRTRVKQEIKQEIARKNAE-----VI 496
                   ||  |..|..:|                   .::|:.|.|.|.:.  ||::     .:
Mouse   551 EALTKMEPPKKGKTPKSVLSVPNKDTVHTQNDMERLEIREQTKSKSEAKWKY--KNSKPDSLLKM 613

  Fly   497 REQQQLEAGRAREAESDTSQSTGVGSVIGMGA-------GV-------------------EY--S 533
            .|:|:||.......:...|.|.....::|..|       ||                   ||  .
Mouse   614 EEEQRLEKSPLAGNKDKFSFSFSNRKLLGSKALRPPSSPGVFGALQSFKEDKAKPVRDEYEYVSD 678

  Fly   534 NGVMKKEQLENGSGVTVGGHGSQP--EATFALPTDTLKYRPPKKMHLATALVAAAASSSSGGGGP 596
            :|.:|.::.      .:....|.|  :.:|.|........|..|..|.:|:..:..||..
Mouse   679 DGELKIDEF------PIRRKKSAPKRDLSFLLDKKEALLMPTSKPKLDSAVYKSDDSSDE----- 732

  Fly   597 VAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEGGQVGGILNMDNCHSPEGGGAKL 661
                      ||.|..|.      |..|....|...|     |....|||::... |.|.|..:.
Mouse   733 ----------GSLHIDTD------TKPGRNAKVKKES-----GSSAAGILDLLQA-SEEVGALEY 775

  Fly   662 SPNLTGTGQPRRRRT--RCKNCAACQRSDCGTCPFCMDMV-----------------KFGGPGRA 707
            :||......|..:..  ...:.|..|.||.     |:...                 |.||..:.
Mouse   776 NPNSQPPASPSTQEAIQGMLSMANLQASDS-----CLQTTWGTGQAKGGSLAAHGARKIGGGNKG 835

  Fly   708 KQTCMMRQCLSPMLPVTAQCVYCHLDGWRQTPVSPQTKQLASADGPSALMECSVCYEIAHPDCAL 772
            ....::::.....:.:.......|||                           .|::  ..|...
Mouse   836 TGKRLLKRTAKNSVDLEDYEEQDHLD---------------------------ACFK--DSDYVY 871

  Fly   773 SQLDGTED-------AADAKGIVNEDLPNSWECPSCCRSGKNYDYKPRHFRARQKSSEVRRVSVS 830
            ..|:..||       :...||  ::|.|.|   |: .|.|.:.   ||..|..::.:.|..:...
Mouse   872 PSLESDEDNPVFKSRSKKRKG--SDDAPYS---PT-ARVGPSV---PRQDRPVREGTRVASIETG 927

  Fly   831 HGQGGAEGHADGNTLLPPPVGQYNDFVFTSESEMESGTVSGHMTHWKHGMKRHHQLEVKTERNNS 895
            .....|:                     .|:.|.:           |:..|::      |:|..:
Mouse   928 LAAAAAK---------------------LSQQEEQ-----------KNRKKKN------TKRKPA 954

  Fly   896 CDTPSPGISPNAIGGDSKVGKRRKSDDGTSVSSSMHESNDAPCGSSAEGAGGAGNANVSTNQWSG 960
            .:|.||.||.:|                 |.|:....::..|..::......|.....||:..|.
Mouse   955 PNTASPSISTSA-----------------SASTGTTSASTTPASTTPASTTPASTTPASTSTASS 1002

  Fly   961 SGGGGGSRKK---NSIRSQLAQQMLNSSTRVLKKPQYVVRPASGTGSSSSSGNGGSASATNGISN 1022
            .....||..:   .|..|.||..            :|.   |:||.|.|.:|......|. |:..
Mouse  1003 QASQEGSSPEPPPESHSSSLADH------------EYT---AAGTFSGSQAGRASQPMAP-GVFL 1051

  Fly  1023 GSNQSGANSCG--AGNGERGTNNGGLSGSNGLG 1053
            ...:..|:|..  |..|:| |..|..:....||
Mouse  1052 TQRRPSASSPNNTAAKGKR-TKKGMATAKQRLG 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367	49/99 (49%)
		PRTases_typeI	<394..>467	CDD:294217	21/151 (14%)
		zf-CXXC	670..716	CDD:251032	9/64 (14%)
		PHD_4	721..801	CDD:293471	14/86 (16%)
		F-box-like	<1073..1108	CDD:289689
		leucine-rich repeat	1102..1125	CDD:275381
		leucine-rich repeat	1126..1149	CDD:275381
		leucine-rich repeat	1150..1173	CDD:275381
		AMN1	1166..>1320	CDD:187754
		leucine-rich repeat	1174..1213	CDD:275381
		leucine-rich repeat	1214..1238	CDD:275381
		leucine-rich repeat	1239..1267	CDD:275381
		leucine-rich repeat	1268..1292	CDD:275381
		leucine-rich repeat	1293..1317	CDD:275381
Phf2	NP_035208.2	PHD_PHF2_like	7..53	CDD:277029
		JmjC	201..264	CDD:214721	34/74 (46%)
		JmjC	236..336	CDD:202224	49/99 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..630		28/183 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	719..755		12/61 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	811..841		3/29 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	871..1080		57/289 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844096
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1633
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000253
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740