Protein Alignment Kdm2 and Kdm2

DIOPT Version :10

• Sequence 1: NP_649864.2
• Gene: Kdm2 / 41090
• FlyBaseID: FBgn0037659
• Length: 1345
• Species: Drosophila melanogaster
• Sequence 2: XP_061502317.1
• Gene: Kdm2 / 1281229
• VectorBaseID: AGAMI1_004393
• Length: 1366
• Species: Anopheles gambiae
• Alignment Length: 1453
• Identity: 757/1453 - (52%)
• Similarity: 905/1453 - (62%)
• Gaps: 265/1453 - (18%)

  Fly    34 PNAKGVQRRQLRERKQRKLYLEEWSLGDEDGEGTRGFSVAEKLESSKFAQAGMVREMRGCDLTVA 98
            |.:....|||||||||:|||.::|:|||:|.||.|||||||||||.:|||:||||||:|.:|||.
Mosquito     8 PISPSKSRRQLRERKQKKLYSDDWTLGDDDYEGARGFSVAEKLESPRFAQSGMVREMKGENLTVG 72

  Fly    99 FLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQY 163
            |||.:||||||||::|.||||::| ...|:::|||:||||||:|||||||||||::||||||::|
Mosquito    73 FLQHNGFNIPLLFKEKTGLGLQVP-TANFSISDVRMCVGSRRMLDVMDVNTQKNVEMTMKEWEKY 136

  Fly   164 YDSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPKV 228
            |:.|.|.:||||||||||||:|:.:||||.|||||||||||||||||::|.|.||||..||||||
Mosquito   137 YEDPVKKKLLNVISLEFSHTKLENYVQSPAIVRQIDWVDVVWPKQLKESQVESTNLLNDMMYPKV 201

  Fly   229 QKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDT 293
            ||||||||||||||||:|||||||||||||||||||||||||:||||||||||||||:|:|||||
Mosquito   202 QKYCLMSVKNCYTDFHVDFGGTSVWYHILRGSKVFWLIPPTDKNLQLYEKWVLSGKQSDVFFGDT 266

  Fly   294 VEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRY 358
            |||||||||||||||||||||||||||||.|||||||||||||||||||...|||:|||||||||
Mosquito   267 VEKCARVYLTAGNTFFIPTGWIHAVYTPTDSLVFGGNFLHSFGIVKQLKITQVEDNTKVPQKFRY 331

  Fly   359 PFFTEMLWYVLARYVHTLLGHSHLEGEASLSEDEMAARPHTHLTHHELFGLKEIVMYLYDLPPQK 423
            ||||||||||||:||:|||||||||||.. .|.|:..:||.||||:||||||:|||||||||.||
Mosquito   332 PFFTEMLWYVLAKYVYTLLGHSHLEGEPG-REHELVGKPHVHLTHYELFGLKDIVMYLYDLPAQK 395

  Fly   424 KNVPSLVLDPVALIKDVRSLVERHCKDQQDLAITGVSVL-------------------------- 462
            ||||.|:.||||||||||:||||||||..:||:|||.||
Mosquito   396 KNVPELIKDPVALIKDVRTLVERHCKDIPELAVTGVPVLHPDLNVSNNSYIREHYEYYSGDGGGN 460

  Fly   463 -----KSPPGSQPPFLLYDRTRVKQEIKQEIARKNAEVIREQQQLEAGRAREAESDTSQSTGVGS 522
                 :.|..|:       |.|.:.|...|...:.||..|.....|..|.:|.|.......|
Mosquito   461 RTTDNEGPRDSR-------RDRDEDEEDDEEGVEEAENRRRNADHERQRLQEVEQQEGNKNG--- 515

  Fly   523 VIGMGAGVEYSNGVMKKEQLENGSGVTV------GGHGSQPEATFALPTDTLKYRPPKKMHLATA 581
                            ..::.||...:|      ..|..||.....:.....:.:..::.|..:.
Mosquito   516 ----------------DNRMGNGGSESVAEAHLQSPHAQQPHRQVIVEQQQQQQQDQQQNHSQSR 564

  Fly   582 LVAAAASSSSGGGGPVAGVGGSAVVGSSHSPTGGGVGPVT------------GAG---GAISVIA 631
            ...|...|....|....|...    |:|.||.|...|..|            |.|   ..:|...
Mosquito   565 HSHAVPRSREQSGETADGDAN----GTSRSPIGSSNGGTTMGPPARYNNHHHGNGDDRNFVSPQP 625

  Fly   632 TSSSYIEGGQVG-GILNMDNCHSPEGGGAKLSPNLTGTGQPRRRRTRCKNCAACQRSDCGTCPFC 695
            ||.:.:....|| |........:...||.|....  |.| |||||||||||.||||||||.|.||
Mosquito   626 TSGNRLPSSGVGRGPYKKHGTGNSGHGGEKRDGG--GNG-PRRRRTRCKNCEACQRSDCGECSFC 687

  Fly   696 MDMVKFGGPGRAKQTCMMRQCLSPMLPVTAQCVYCHLDGWRQTPV-SP-QTK-QLASADGPSALM 757
            :|||||||||||||||||||||.|||||||||::|:||||||.|: :| |.| |....:||||||
Mosquito   688 LDMVKFGGPGRAKQTCMMRQCLQPMLPVTAQCIHCNLDGWRQAPIMAPAQAKLQAQMQEGPSALM 752

  Fly   758 ECSVCYEIAHPDCALSQLDGTEDAADAKGIVNEDLPNSWECPSCCRSGKNYDYKPRHFRARQKSS 822
            ||||||||:|||||      ...|.:|:||||:||||||||||||:||||.||:|||||||||||
Mosquito   753 ECSVCYEISHPDCA------QRAAPEAQGIVNDDLPNSWECPSCCKSGKNTDYRPRHFRARQKSS 811

  Fly   823 EVRRVSVS----------------HGQGGA------------EGHADGNTLLPPPVGQYNDFVF- 858
            ::||:|.|                .|.|||            :|...|..:..|...::.|.:.
Mosquito   812 DIRRMSCSSDASSAHNAEFGRIGGSGHGGAGSGGEGSMNSTGDGMMAGANVSAPRAPRFQDDMLY 876

  Fly   859 -------------------------TSESEMESGT---VSGHMTHWKHGMKRHHQL--------- 886
                                     ..:.:|.||:   .||      .|.|.||.|
Mosquito   877 DFAVSGSAVIVGSKGGNILFERKPKIKDEDMSSGSEYDASG------VGKKMHHSLNSSPGAGTA 935

  Fly   887 --------EVKTERNNSCDTPSPGISPN-----------------------AIGGDSKVGKRRKS 920
                    |||.|..:  ..|:.|...|                       |...|....|||||
Mosquito   936 MGGGSMKVEVKDEPLD--HHPNHGYPANHHATSVIKDGREMQREQALSSSCAASADGVAVKRRKS 998

  Fly   921 DDGTSVSSSMHESNDAPCGSSAEGAGGAGNANVSTNQWSGSGGGGGSRKKNSIRSQLAQQMLNSS 985
            |:|.::::..|             :||.|......|:...|.||...|||:|.|.|||.|:.::|
Mosquito   999 DEGGAINTHHH-------------SGGTGTGAADGNEAKNSHGGSLPRKKSSQRMQLAHQIHSTS 1050

  Fly   986 TRVLKKPQYVVRPASGTGSSSSSGNGGSASATNGISNGSNQSGANSCGAGNGERGTNNGGLSGSN 1050
            |:.:|||.|.:||||...:.:.|                                     |||
Mosquito  1051 TKPMKKPLYPIRPASVAHTPTMS-------------------------------------LSG-- 1076

  Fly  1051 GLGNQHYSSSQNLALDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVDPDLWKKMNCSEHKMSAS 1115
                       |.|||...|..:|||||.:|||||..|||.|:|.||||.|||:|||:|:|:|.:
Mosquito  1077 -----------NYALDAPCLLAVFRYLPPETLVTCTMVCKTWANIAVDPSLWKRMNCAEYKLSPN 1130

  Fly  1116 LLTAIVRRQPEHLILDWTQIAKRQLAWLVARLPALKNLSLQNCPIQAVLALHTCLCPPLQTLDLS 1180
            ||:|||||||||||:||..:.|||:.||::|:|.|||||||...|||||.||||:|||||.||||
Mosquito  1131 LLSAIVRRQPEHLIMDWIGLGKRQVTWLISRIPGLKNLSLQGTHIQAVLGLHTCMCPPLQVLDLS 1195

  Fly  1181 FVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLAGTDISDVAVRYITQSLPYLRHLDLS 1245
            |:.||||.|||:||||||||||||:|||:|||:||::|:||.||||||:|||||.||.|.|||||
Mosquito  1196 FIAGLNDFAIREILSPPKDSRPGLADSKSRLRNLKMLKVAGADISDVALRYITQGLPNLTHLDLS 1260

  Fly  1246 SCQRITDAGVAQIGTSTTATARLTELNLSACRLVSENALEHLAKCEGLIWLDLRHVPQVSTQSVI 1310
            ||||||||.:||||||..|...|.||:||.|:|::|.:|:|||||:.|..|||.|||||||||:|
Mosquito  1261 SCQRITDAAIAQIGTSPAAIKTLVELDLSCCKLITELSLDHLAKCDALTRLDLSHVPQVSTQSMI 1325

  Fly  1311 RFASNSKHDLCVRDIKLVERRRR 1333
            :|||.||:||.:.|||||::|::
Mosquito  1326 KFASISKNDLQLHDIKLVDKRKQ 1348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_649864.2	cupin_RmlC-like	231..331	CDD:477354	94/99 (95%)
		CTD_Jhd1-like	399..465	CDD:412024	51/96 (53%)
		zf-CXXC	670..716	CDD:366873	40/45 (89%)
		PHD_4	721..802	CDD:465288	54/83 (65%)
		F-box-like	<1073..1105	CDD:463757	22/31 (71%)
		leucine-rich repeat	1102..1125	CDD:275381	15/22 (68%)
		leucine-rich repeat	1126..1149	CDD:275381	12/22 (55%)
		leucine-rich repeat	1150..1173	CDD:275381	17/22 (77%)
		AMN1	1166..>1320	CDD:187754	111/153 (73%)
		leucine-rich repeat	1174..1213	CDD:275381	31/38 (82%)
		leucine-rich repeat	1214..1238	CDD:275381	17/23 (74%)
		leucine-rich repeat	1239..1267	CDD:275381	21/27 (78%)
		leucine-rich repeat	1268..1292	CDD:275381	14/23 (61%)
		leucine-rich repeat	1293..1317	CDD:275381	17/23 (74%)
Kdm2	XP_061502317.1	None