Protein Alignment Kdm2 and phf2

DIOPT Version :10

• Sequence 1: NP_649864.2
• Gene: Kdm2 / 41090
• FlyBaseID: FBgn0037659
• Length: 1345
• Species: Drosophila melanogaster
• Sequence 2: XP_031757142.1
• Gene: phf2 / 100492144
• XenbaseID: XB-GENE-6065306
• Length: 1070
• Species: Xenopus tropicalis
• Alignment Length: 1279
• Identity: 294/1279 - (22%)
• Similarity: 445/1279 - (34%)
• Gaps: 414/1279 - (32%)

  Fly    34 PNAKGVQRRQLRERKQRKLYLEEWSLGDEDGEGT------RGFSV-AEKLESSKFAQA-GMVREM 90
            ||.:....:...::|      :.|...| .|:.|      .|..| .::|.:..|..| .:|:::
 Frog    51 PNCEKTHGKSTLKKK------KNWPKQD-TGQATEVKPVQNGSQVFIKELRNRTFPSAEDVVKKL 108

  Fly    91 RGCDLTVAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQM 155
            .|..|||.:.::.||..|:|...|..|||.:| ...|.|:||...||..|.:||.||..||:.:|
 Frog   109 NGNQLTVEYFEETGFTEPILVPKKDALGLTVP-AATFYVSDVENYVGPERAVDVTDVTKQKDCKM 172

  Fly   156 TMKEWQQYYDSPQKDRLLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLL 220
            .:||:..||.|..:.|:|||.:||||.||:..||::||||:::.||:..||.....|:
 Frog   173 KLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEAPEIVKKLSWVENHWPDDALLAK------- 230

  Fly   221 GGMMYPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQ 285
                 |||.||||:.||:.|||||||.||.|.|||:|:|.|:|:||.|...|:.|||:|..:...
 Frog   231 -----PKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIRPESANISLYERWRSASNH 290

  Fly   286 ADIFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDST 350
            .::||.|.|:||.:..:..|.|.|||:|||:|..||...|.|.|:||||..:..|::...||...
 Frog   291 CEMFFADQVDKCYKCAVKQGQTLFIPSGWIYATLTPVDCLAFSGHFLHSLSVEMQMRAYEVEKRL 355

  Fly   351 KVPQKFRYPFFTEMLWYVLARYVHTLLGHSHLEGEASLSEDEMAARPH----------------- 398
            |:....::|.|....|||         |...||...:|.:......||
 Frog   356 KIISLTQFPNFETACWYV---------GRHLLEKFKALHKAGKQPAPHLVQGAKILNGAFRSWTK 411

  Fly   399 -THLTHHELFGLKEIVMYLYDLPPQKKNVPSLVLDPVALIKDVRSLVERHCKDQQDLAITGVSVL 462
             ..|..||           .:||...|        |..||||:          .:::.:|
 Frog   412 KNALLEHE-----------DELPEHFK--------PSQLIKDL----------AKEIRLT----- 442

  Fly   463 KSPPGSQPPFLLYDRTRVKQEIKQEIARKNAEVIREQQQLEAGRAREAESDTSQSTGVGSVIGMG 527
                           ....:.||.|:   :|.||.|:..:    ..:.|.|...|    .|....
 Frog   443 ---------------ENASKVIKTEV---SANVIAERNNI----VEKIEKDEPAS----PVPESP 481

  Fly   528 AGVEYSNGVMKKEQLENGSGVTVGGHGSQPEATFALPTDTLKYRPPKKMHLATALVAAAASSSSG 592
            ..||......||:..:|...:       :|......|......:|||.........|..|.....
 Frog   482 PPVEKMEKAPKKKTAKNEKPL-------KPPKPPKPPKPPKVAKPPKVAKPNKTPKAPKAQKEKD 539

  Fly   593 GGGPVAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEGGQVGGILNMDNCHSPEGG 657
            ||                                                          ..:|.
 Frog   540 GG----------------------------------------------------------KKKGK 546

  Fly   658 GAKLSP-NLTGTGQPRRRRTRCKNC-AACQRSDCGTCPFCMDMVKFGGPGRAK-------QTCMM 713
            ..|.|| :|..|.......|..|:. .|.:....|..|    ..:...|.:.:       :.|.|
 Frog   547 KVKESPISLPTTPDLEPHETLMKDTPIAAEAPKKGMVP----KEELSVPTKEEAPKHNHVEKCEM 607

  Fly   714 RQCLSPMLPVTAQCVYCHLDGWRQTPVSPQTKQLASADGPSALMECSVCYEI------AHPDCAL 772
            |:                     |..:..:.|.......|.:|::....:.:      |:.|...
 Frog   608 RE---------------------QNKIKTEAKWKYKNSKPDSLLKMEEEHRLQKTLFSANKDHKF 651

  Fly   773 SQLDGTEDAADAKGIVNEDLPNSWECPSCCRSGK------NYDY-------KPRHFRARQKSSEV 824
            ......:....:|||..::.|:.:......:..|      .|:|       |...|..|:|.:..
 Frog   652 KFSFTNKKLFGSKGIKTQNSPSIFGSLQNFKEDKTKPVRDEYEYVSDDGELKIDEFPIRRKKTTT 716

  Fly   825 RRVSVSHGQGGAEGHADGNTLLPPPVGQYNDFVFTSESEMESGTVSGHMTHWKHGMKRHHQLEVK 889
            :|                            |..|.|:::
 Frog   717 KR----------------------------DLSFLSDNK-------------------------- 727

  Fly   890 TERNNSCDTPSPGISPNAIGGDSKVGKRRKSDDGTSVSSSMH-ESNDAPCGSSAEGAGGAGNANV 953
                   :||.|..|......:||.    |||| ||...|:| ::.:.|          |.|:.|
 Frog   728 -------ETPPPPPSKKPKVQESKY----KSDD-TSDEDSLHIDTEEKP----------ARNSRV 770

  Fly   954 STNQWSGSGGGGGSRKKNSIRSQLAQQMLNSSTRVLKKPQYVVRPASGTGSSSSSGNGGSASATN 1018
            ..:  |||..|             ...:|.:|..|           .|...:|:|....|.|...
 Frog   771 KKD--SGSSAG-------------ILDLLQASKEV-----------GGLDYNSNSQPPASPSTQE 809

  Fly  1019 GI-----------------SNGSNQSGANSCGAGNGERGTNNGGLSGSNGLGNQHYSSSQN---L 1063
            .|                 |..:||:..||..|.|.::       ||:|.|.|:..|...|   :
 Frog   810 AIQGMLSMANLPSDSCLQTSWSANQAKNNSISAQNSKK-------SGNNKLANKRASKKANKNSI 867

  Fly  1064 ALDPTVLKIIFRY-LPQDTLVTCCSVCK-VWSNAAVDPD------LWKKMNCSE---HKMSASLL 1117
            ||:.        | ..||.|..|..... |:.:...|.|      ..||..||:   :..:|.:.
 Frog   868 ALED--------YDEDQDNLEACFKDSDYVYPSLESDEDNPVFKSRAKKRKCSDDAPYSPTARVA 924

  Fly  1118 TAIVRRQPEHLILDWTQIAKRQ--LAWLVARL-------PALKNLSLQ----NCPIQAVLALHTC 1169
            .:|.|:  :..:.:.|::|..:  ||...|:|       |..|..|.:    |.|        ..
 Frog   925 PSIPRQ--DRPVREGTRVASIETGLAAAAAKLSQQEDQKPKKKKTSKKKLSPNMP--------NA 979

  Fly  1170 LC-----PPLQTL----DLSFVRGLNDAAIRDILSPPKDSRPGL 1204
            ||     .|..:|    |..:..|.:...:..:...|:...||:
 Frog   980 LCQEGSSSPEVSLSGPTDHEYTAGASTFGVAQVNRGPQPMAPGV 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_649864.2	cupin_RmlC-like	231..331	CDD:477354	50/99 (51%)
		CTD_Jhd1-like	399..465	CDD:412024	12/65 (18%)
		zf-CXXC	670..716	CDD:366873	9/53 (17%)
		PHD_4	721..802	CDD:465288	10/86 (12%)
		F-box-like	<1073..1105	CDD:463757	9/39 (23%)
		leucine-rich repeat	1102..1125	CDD:275381	7/25 (28%)
		leucine-rich repeat	1126..1149	CDD:275381	6/31 (19%)
		leucine-rich repeat	1150..1173	CDD:275381	6/31 (19%)
		AMN1	1166..>1320	CDD:187754	9/48 (19%)
		leucine-rich repeat	1174..1213	CDD:275381	6/35 (17%)
		leucine-rich repeat	1214..1238	CDD:275381
		leucine-rich repeat	1239..1267	CDD:275381
		leucine-rich repeat	1268..1292	CDD:275381
		leucine-rich repeat	1293..1317	CDD:275381
phf2	XP_031757142.1	PHD_PHF2_like	7..53	CDD:277029	1/1 (100%)
		cupin_RmlC-like	236..336	CDD:477354	50/99 (51%)
		JHD	340..443	CDD:465515	27/160 (17%)