DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and fbxl12

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	XP_002933934.2	Gene:	fbxl12 / 100135148	XenbaseID:	XB-GENE-942694	Length:	350	Species:	Xenopus tropicalis

Alignment Length:	299	Identity:	76/299 - (25%)
Similarity:	127/299 - (42%)	Gaps:	58/299 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1055 QHYSSSQNLALD---PTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVDPDLWKKMNCSEHKMSASL 1116
            ::.|.|..|||.   .:||..:..:|....||....|||.|....:|..||:.:|.:.:|:.:..
Frog    35 ENSSVSGTLALSWLPDSVLLEVLSFLSIRDLVRSGRVCKRWRTLVMDKTLWRHINLTPYKLDSKT 99

  Fly  1117 LTAIVRRQ--P--EHLILDWT-QIAKRQ-------LAWLVARLPALKNLSLQNCPIQAV------ 1163
            |..:||.:  |  :.|.|..| :..|:|       |..:.:|...|:.|.|:...:.::
Frog   100 LWHLVRHKFVPSLQTLKLRGTLRSVKKQEFLTMAVLKEIESRFHNLETLHLEQTNLHSLSYCHFP 164

  Fly  1164 -----LALHTC---------------LCPPLQTLDLSFVRGLNDAAIRDI--LSPPKD------- 1199
                 |.|:.|               ..|.|:.|.|:.|...::..:..|  ||..|.
Frog   165 STLKTLQLNQCELPANWFKTPPNKGRTFPKLEHLFLNSVPSFSNHHLETICSLSALKTLSLCGTY 229

  Fly  1200 --SRPGLSDSKTRLRDLKVMKLAGTDISDVAVRYITQSLPYLRHLDLSSCQRITDAGVAQIGTST 1262
              :..|:.||...|:.|:.:||.|..|||:.:..|...|.:|:.|.|:....::|||:|.:.:..
Frog   230 RVTDAGIPDSLPHLKGLEHLKLQGCYISDITLHLIGCHLKHLQTLALTDVSSVSDAGLACLSSVK 294

  Fly  1263 TATARLTELNLSACRLVSENALEHLAKCEGLIWLDLRHV 1301
            |    |.:|.|.....:|.|::  :|.|..|..|...|:
Frog   295 T----LEKLWLEYSTHLSLNSI--IAVCGKLPALSYLHL 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689	11/34 (32%)
		leucine-rich repeat	1102..1125	CDD:275381	6/24 (25%)
		leucine-rich repeat	1126..1149	CDD:275381	7/30 (23%)
		leucine-rich repeat	1150..1173	CDD:275381	6/48 (13%)
		AMN1	1166..>1320	CDD:187754	42/162 (26%)
		leucine-rich repeat	1174..1213	CDD:275381	12/49 (24%)
		leucine-rich repeat	1214..1238	CDD:275381	9/23 (39%)
		leucine-rich repeat	1239..1267	CDD:275381	8/27 (30%)
		leucine-rich repeat	1268..1292	CDD:275381	7/23 (30%)
		leucine-rich repeat	1293..1317	CDD:275381	3/9 (33%)
fbxl12	XP_002933934.2	F-box-like	45..88	CDD:372399	13/42 (31%)
		leucine-rich repeat	60..84	CDD:275381	8/23 (35%)
		leucine-rich repeat	85..107	CDD:275381	6/21 (29%)
		leucine-rich repeat	112..144	CDD:275381	7/31 (23%)
		leucine-rich repeat	145..194	CDD:275381	6/48 (13%)
		leucine-rich repeat	195..219	CDD:275381	6/23 (26%)
		LRR_RI	<216..343	CDD:393385	34/118 (29%)
		leucine-rich repeat	220..245	CDD:275381	5/24 (21%)
		leucine-rich repeat	246..270	CDD:275381	9/23 (39%)
		leucine-rich repeat	271..295	CDD:275381	7/23 (30%)
		leucine-rich repeat	296..321	CDD:275381	8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910