DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm2 and Fbxl13

DIOPT Version :9

Sequence 1:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster
Sequence 2:	XP_038962809.1	Gene:	Fbxl13 / 100125363	RGDID:	1642425	Length:	823	Species:	Rattus norvegicus

Alignment Length:	300	Identity:	69/300 - (23%)
Similarity:	122/300 - (40%)	Gaps:	53/300 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1038 ERGTNNGGLSGSNGLGNQHYSSSQNLALDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVDPDLW 1102
            |:..|..|.....|:.::......::..|..|:: ||.||....||:|..|.:.|.:......||
  Rat   219 EKPINIEGSFSDFGVTDKRIVFDISVLPDQAVVQ-IFVYLTFKDLVSCSQVNRSWMSMIQRGSLW 282

  Fly  1103 KKMNCSEHKMSASLLTAIVRRQPEHLILDWTQIAKRQLAWLVARLPALKNLSLQNCPIQAVLALH 1167
            ..::.|..|..|.....             |.:.|    |   ||..|: |:.:.|.::|.....
  Rat   283 NSIDFSTVKNIADRCVV-------------TTLQK----W---RLNVLR-LNFRGCVLRAKTLKS 326

  Fly  1168 TCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLAGTDISDVAVRYI 1232
            ...|..||.|::|......|.::|.|    .:..||          :..:.|:.|.|::..:|.:
  Rat   327 VSHCKNLQELNVSDCPSFTDESMRHI----SEGCPG----------VLYLNLSNTTITNRTMRLL 377

  Fly  1233 TQSLPYLRHLDLSSCQRITDAGVAQIGTSTTATARLTELNLSACRLVSENALEHLA-KCEGLIWL 1296
            .:....|::|.|:.|::.||.|:..:... ....:|..|:||.|..:|.....::| .|.|::.|
  Rat   378 PRYFHNLQNLSLAYCRKFTDKGLQYLNLG-NGCHKLIYLDLSGCTQISVQGFRNIANSCTGIMHL 441

  Fly  1297 DLRHVPQVSTQSVIRFASNSKHDLCVRDIKLVERRRRNST 1336
            .:..:|.::             |.||:  .|||:..|.|:
  Rat   442 TINDMPTLT-------------DNCVK--VLVEKCPRISS 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471
		F-box-like	<1073..1108	CDD:289689	11/34 (32%)
		leucine-rich repeat	1102..1125	CDD:275381	4/22 (18%)
		leucine-rich repeat	1126..1149	CDD:275381	5/22 (23%)
		leucine-rich repeat	1150..1173	CDD:275381	5/22 (23%)
		AMN1	1166..>1320	CDD:187754	32/154 (21%)
		leucine-rich repeat	1174..1213	CDD:275381	9/38 (24%)
		leucine-rich repeat	1214..1238	CDD:275381	4/23 (17%)
		leucine-rich repeat	1239..1267	CDD:275381	7/27 (26%)
		leucine-rich repeat	1268..1292	CDD:275381	8/24 (33%)
		leucine-rich repeat	1293..1317	CDD:275381	2/23 (9%)
Fbxl13	XP_038962809.1	Sfi1	<134..>214	CDD:400658
		F-box-like	242..286	CDD:403981	13/44 (30%)
		leucine-rich repeat	257..270	CDD:275381	5/12 (42%)
		leucine-rich repeat	282..308	CDD:275381	8/45 (18%)
		AMN1	308..477	CDD:187754	44/189 (23%)
		leucine-rich repeat	309..332	CDD:275381	5/23 (22%)
		leucine-rich repeat	333..358	CDD:275381	7/28 (25%)
		leucine-rich repeat	359..383	CDD:275381	4/23 (17%)
		leucine-rich repeat	384..402	CDD:275381	7/17 (41%)
		leucine-rich repeat	412..437	CDD:275381	8/24 (33%)
		leucine-rich repeat	438..463	CDD:275381	8/39 (21%)
		leucine-rich repeat	464..486	CDD:275381	1/2 (50%)
		leucine-rich repeat	488..513	CDD:275381
		leucine-rich repeat	514..534	CDD:275381
		AMN1	525..733	CDD:187754
		leucine-rich repeat	539..563	CDD:275381
		leucine-rich repeat	567..592	CDD:275381
		leucine-rich repeat	593..617	CDD:275381
		leucine-rich repeat	618..641	CDD:275381
		leucine-rich repeat	642..667	CDD:275381
		leucine-rich repeat	668..693	CDD:275381
		leucine-rich repeat	694..719	CDD:275381
		leucine-rich repeat	720..745	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810