Protein Alignment Rel and REL

DIOPT Version :10

• Sequence 1: NP_477094.1
• Gene: Rel / 41087
• FlyBaseID: FBgn0014018
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_002899.1
• Gene: REL / 5966
• HGNCID: 9954
• Length: 619
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 129/399 - (32%)
• Similarity: 193/399 - (48%)
• Gaps: 76/399 - (19%)

  Fly   150 PQLRIVEQPVEK-FRFRYKSEMHGTHGSLNGANSKRTPKTFPEVTLCNYDGPAVIRCSLFQTNLD 213
            |.:.|:|||.:: .|||||.|.... ||:.|.:|....:|:|.:.:.||.|...:|.:|...| |
Human     8 PYIEIIEQPRQRGMRFRYKCEGRSA-GSIPGEHSTDNNRTYPSIQIMNYYGKGKVRITLVTKN-D 70

  Fly   214 --SPHSHQLVVRKDDRDVCDPHDLHVSKERGYVAQFINMGIIHTAKKYIFEELCKKKQDRLVFQM 276
              .||.|.| |.||.||  ..::....:||..:. |.|:||....||.:.|.:.    .|:...:
Human    71 PYKPHPHDL-VGKDCRD--GYYEAEFGQERRPLF-FQNLGIRCVKKKEVKEAII----TRIKAGI 127

  Fly   277 NRRELSHKQLQELHQETEREAKDMNLNQVRLCFEAFKIEDNGAWVPLAPPVYSNAINNRKSAQTG 341
            |...:..|||.::        :|.:||.|||||:.|..:::|......|||.||.|.:.::..|.
Human   128 NPFNVPEKQLNDI--------EDCDLNVVRLCFQVFLPDEHGNLTTALPPVVSNPIYDNRAPNTA 184

  Fly   342 ELRIVRLSKPTGGVMGNDELILLVEKVSKKNIKVRFFEEDEDGETVWEAYAKFRESDVHHQYAIV 406
            ||||.|::|..|.|.|.||:.||.:||.|.:|:|||...|      |||...|.::|||.|.|||
Human   185 ELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLND------WEAKGIFSQADVHRQVAIV 243

  Fly   407 CQTPPYKDKDVDREVNVYIELIRPSDDERSFPALPFRYKP-------------RSVIVSRK---- 454
            .:|||| .|.:...|.|.::|.||||.|.| .::.|||.|             ::.::.:|
Human   244 FKTPPY-CKAITEPVTVKMQLRRPSDQEVS-ESMDFRYLPDEKDTYGNKAKKQKTTLLFQKLCQD 306

  Fly   455 RRRTG------------SSANSSSSGTESSNNSLDLPKTLGLAQPPNGL-------------PNL 494
            ...||            :|.:..:..::|:..:::.|:     :|..||             |||
Human   307 HVETGFRHVDQDGLELLTSGDPPTLASQSAGITVNFPE-----RPRPGLLGSIGEGRYFKKEPNL 366

  Fly   495 SQHDQTISE 503
            ..||..:.|
Human   367 FSHDAVVRE 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rel	NP_477094.1	RHD-n_Relish	150..336	CDD:143644	63/188 (34%)
		IPT_NFkappaB	343..446	CDD:238582	48/102 (47%)
		ANKYR	590..805	CDD:440430
		ANK repeat	640..671	CDD:293786
		ANK repeat	673..708	CDD:293786
REL	NP_002899.1	RHD-n_c-Rel	8..179	CDD:143649	63/188 (34%)
		IPT_NFkappaB	186..281	CDD:238582	48/102 (47%)
		Nuclear localization signal. /evidence=ECO:0000255	290..295		0/4 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..437
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	572..593