DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rel and nfkb1

DIOPT Version :9

Sequence 1:	NP_477094.1	Gene:	Rel / 41087	FlyBaseID:	FBgn0014018	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	XP_021336944.1	Gene:	nfkb1 / 565756	ZFINID:	ZDB-GENE-121204-3	Length:	539	Species:	Danio rerio

Alignment Length:	398	Identity:	135/398 - (33%)
Similarity:	201/398 - (50%)	Gaps:	77/398 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 PATVPPSQNFGYHQNGL--ASDGDIKHVPQLRIVEQPVEK-FRFRYKSEMHGTHGSLNGANSKRT 185
            |.|.|     ..|.|.:  ..||     |.|:|.|||.:: |||||..| ..:||.|.||:|::.
Zfish    34 PTTFP-----AIHNNNIMRTVDG-----PCLQITEQPKQRGFRFRYGCE-GPSHGGLPGASSEKN 87

  Fly   186 PKTFPEVTLCNYDGPAVIRCSLFQTNLDSP--HSHQLVVRKDDRDVC----DPHDLHVSKERGYV 244
            .|::|:|.:|||.|||.:...|. ||...|  |:|.||.::.|:.:|    .|.|..:|
Zfish    88 RKSYPQVQICNYQGPARVVVQLV-TNSQHPHLHAHSLVGKQCDKGICISDMQPKDSSIS------ 145

  Fly   245 AQFINMGIIHTAKKYIFEELCKKKQDRLVFQMNRRELSHKQLQELH---------QETER----- 295
              |.|:||:|..||.:.:.|.::..:......|.....|.::..|.         .|.||
Zfish   146 --FPNLGILHVTKKNVSKVLEERMMEAYRMGYNYGIFIHPEIDALQGEVRMPRELNEAERSLISS 208

  Fly   296 ----EAKDMNLNQVRLCFEAFKIEDNGAWVPLAPPVYSNAINNRKSAQTGELRIVRLSKPTGGVM 356
                :||:|:|:.|||.|.||..:.:|.:.....||.|..|.:.|:.....|:|||:.:..|.|.
Zfish   209 AASQQAKEMDLSVVRLMFTAFLPDSDGGFSRRLEPVISEPIYDSKAPNASNLKIVRMDRTAGCVT 273

  Fly   357 GNDELILLVEKVSKKNIKVRFFEEDEDGETVWEAYAKFRESDVHHQYAIVCQTPPYKDKDVDREV 421
            |.:|:.||.:||.|.:|:|||:|:|:.|   ||||..|..:|||.|:|||.:||.|:|.::.:.:
Zfish   274 GGEEVYLLCDKVQKDDIQVRFYEDDDSG---WEAYGDFSPTDVHRQFAIVFKTPKYRDLNLQKPI 335

  Fly   422 NVYIELIRPSDDERSFPALPFRYKPRSV---IVSRKRRRT-----------------------GS 460
            :|:::|.|.||:|.|.|. ||.|.|:.:   .|.|||::|                       ||
Zfish   336 SVFVQLKRKSDNETSEPK-PFTYHPQIIDKEEVQRKRQKTLPNFQDYSGAGGGAGGMFRGGGGGS 399

  Fly   461 SANSSSSG 468
            :|....||
Zfish   400 TAGGGPSG 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rel	NP_477094.1	RHD-n_Relish	150..336	CDD:143644	69/210 (33%)
		IPT_NFkappaB	343..446	CDD:238582	47/102 (46%)
		ANK	638..766	CDD:238125
		ANK repeat	640..671	CDD:293786
		Ank_4	641..691	CDD:290365
		ANK repeat	673..708	CDD:293786
		Ank_2	678..775	CDD:289560
nfkb1	XP_021336944.1	RHD-n	52..253	CDD:298664	69/210 (33%)
nfkb1	XP_021336944.1	IPT_NFkappaB	260..359	CDD:238582	47/102 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3646
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0004970
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105214
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.870