DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rel and NFKB2

DIOPT Version :9

Sequence 1:	NP_477094.1	Gene:	Rel / 41087	FlyBaseID:	FBgn0014018	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	XP_016871767.1	Gene:	NFKB2 / 4791	HGNCID:	7795	Length:	1081	Species:	Homo sapiens

Alignment Length:	895	Identity:	242/895 - (27%)
Similarity:	380/895 - (42%)	Gaps:	197/895 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 PAPATVPPSQNFGYHQNGLASDGDIKHVPQLRIVEQPVEK-FRFRYKSEMHGTHGSLNGANSKRT 185
            |||.|               :||     |.|.|||||.:: |||||..| ..:||.|.||:|::.
Human   211 PAPET---------------ADG-----PYLVIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKG 254

  Fly   186 PKTFPEVTLCNYDGPAVIRCSLFQTNLDSP--HSHQLVVRK-DDRDVC----DPHDLHVSKERGY 243
            .||:|.|.:|||:|||.|...|. |:.|.|  |:|.||.:: .:..:|    .|.|:
Human   255 RKTYPTVKICNYEGPAKIEVDLV-THSDPPRAHAHSLVGKQCSELGICAVSVGPKDM-------- 310

  Fly   244 VAQFINMGIIHTAKKYIFEELCKKKQDRLVFQMNRRELSHKQLQELHQETEREAKDMNLNQVRLC 308
            .|||.|:|::|..||.:...:.:|.| |...:...:.|:..:.:||.||.:...|.|:|:.|||.
Human   311 TAQFNNLGVLHVTKKNMMGTMIQKLQ-RQRLRSRPQGLTEAEQRELEQEAKELKKVMDLSIVRLR 374

  Fly   309 FEAFKIEDNGAW-VPLAPPVYSNAINNRKSAQTGELRIVRLSKPTGGVMGNDELILLVEKVSKKN 372
            |.||....:|:: :|| .||.|..|::.||.....|:|.|:.|..|.|.|.||:.||.:||.|.:
Human   375 FSAFLRASDGSFSLPL-KPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDD 438

  Fly   373 IKVRFFEEDEDGETVWEAYAKFRESDVHHQYAIVCQTPPYKDKDVDREVNVYIELIRPS----DD 433
            |:|||:|:||:|   |:|:..|..:|||.|||||.:||||....::|.|.|:::|.|..    .|
Human   439 IEVRFYEDDENG---WQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSD 500

  Fly   434 ERSFPALPFRYKPRSVIVSRKRRRT----------------GSSANSSSSGTESSNNSLD-LPKT 481
            .:.|...|.......  |.||||:.                ||...:...|......||. .|.:
Human   501 SKQFTYYPLVEDKEE--VQRKRRKALPTFSQPFGGGSHMGGGSGGAAGGYGGAGGGGSLGFFPSS 563

  Fly   482 LGLAQPPNGLPNLSQHDQTISEEFGREKHLNEFIASEDFRKLIEHNSSDLEKICQLDMGELQHDG 546
            |..:...:|...:..:...     |....:...:.|.|                         .|
Human   564 LAYSPYQSGAGPMGCYPGG-----GGGAQMAATVPSRD-------------------------SG 598

  Fly   547 HNRAEVPSHRNRTIKCLDDLFEIYKQDRISPIKI------SHHKVEKWFI-----------EHAL 594
            ...|| ||..:||.:|.....|:.::.|....::      |...:..:.:           .|.|
Human   599 EEAAE-PSAPSRTPQCEPQAPEMLQRAREYNARLFGLAQRSARALLDYGVTADARALLAGQRHLL 662

  Fly   595 --NNYNRDTLLHEVISHKKDKLKLAIQTIQVMNYFNLKDVVNSTLNADGDSALHVACQQDRAHYI 657
              .:.|.||.||..|.|  .:..:..|.:.|:::.....|||.| |....:.||:|....:...:
Human   663 TAQDENGDTPLHLAIIH--GQTSVIEQIVYVIHHAQDLGVVNLT-NHLHQTPLHLAVITGQTSVV 724

  Fly   658 RPLLGMGCNPNLKNNAGNTPLHVAVK-----EEHLSCVESFLNGVPTVQLDLSLTNDDGLTPLHM 717
            ..||.:|.:|.|.:..|::.:|:|::     .|.|..:  ..:|.|.|...|.:.:.:||.|:|:
Human   725 SFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRAL--LQSGAPAVPQLLHMPDFEGLYPVHL 787

  Fly   718 AIRQNKYDVAKKLISYDRTSISVANTMDGNNALHMAVLEQSVELLVLILDAQNENLTDILQAQNA 782
            |:|....:....|:. ....:.......|..|||:|...:.:.|:..::.....|    :.|:..
Human   788 AVRARSPECLDLLVD-SGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN----VNARTF 847

  Fly   783 AGHTPLELAERKANDRVVQLL----KNVYPEKGELAMTWIP-CKVKEEIDSSSDESSDAGQLEIK 842
            ||:|||.||.......:.:||    .:::.|..|      | |.:.....|.||..|:..:.:.:
Human   848 AGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEE------PLCPLPSPPTSDSDSDSEGPEKDTR 906

  Fly   843 SE-------EMDIETK--------DEDSVELDLS----SGPRRQKDESSRDTEMDNNKLQLLLKN 888
            |.       ::...||        .::::|..|:    :||    ..|..||.:.|
Human   907 SSFRGHTPLDLTCSTKVKTLLLNAAQNTMEPPLTPPSPAGP----GLSLGDTALQN--------- 958

  Fly   889 KFIYDRLCSLLNQPLGHGSDPQDRKWMQLARQTHLKQFAFIWLGAEDLLD 938
                  |..||:.|...||      |.:||.:          ||...|:|
Human   959 ------LEQLLDGPEAQGS------WAELAER----------LGLRSLVD 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rel	NP_477094.1	RHD-n_Relish	150..336	CDD:143644	73/194 (38%)
		IPT_NFkappaB	343..446	CDD:238582	45/106 (42%)
		ANK	638..766	CDD:238125	31/132 (23%)
		ANK repeat	640..671	CDD:293786	8/30 (27%)
		Ank_4	641..691	CDD:290365	13/54 (24%)
		ANK repeat	673..708	CDD:293786	9/39 (23%)
		Ank_2	678..775	CDD:289560	22/101 (22%)
NFKB2	XP_016871767.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BACK
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3266
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47610
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0004970
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105214
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6960
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910