DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rel and NFKB1

DIOPT Version :9

Sequence 1:	NP_477094.1	Gene:	Rel / 41087	FlyBaseID:	FBgn0014018	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	NP_001369554.1	Gene:	NFKB1 / 4790	HGNCID:	7794	Length:	969	Species:	Homo sapiens

Alignment Length:	935	Identity:	248/935 - (26%)
Similarity:	403/935 - (43%)	Gaps:	171/935 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 SDGDIKHVPQLRIVEQPVEK-FRFRYKSEMHGTHGSLNGANSKRTPKTFPEVTLCNYDGPAVIRC 205
            :||     |.|:|:|||.:: |||||..| ..:||.|.||:|::..|::|:|.:|||.|||.:..
Human    40 ADG-----PYLQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIV 98

  Fly   206 SLFQTNLD-SPHSHQLVVRKDDRDVC----DPHDLHVSKERGYVAQFINMGIIHTAKKYIFEELC 265
            .|.....: ..|:|.||.:..:..:|    .|.|:        |..|.|:||:|..||.:||.|.
Human    99 QLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDM--------VVGFANLGILHVTKKKVFETLE 155

  Fly   266 KKKQDRLVFQMNRRELSH-------------KQLQELHQETEREA-----KDMNLNQVRLCFEAF 312
            .:..:..:...|...|.|             :||.:..:|..|:|     |:|:|:.|||.|.||
Human   156 ARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAF 220

  Fly   313 KIEDNGAWVPLAPPVYSNAINNRKSAQTGELRIVRLSKPTGGVMGNDELILLVEKVSKKNIKVRF 377
            ..:..|::.....||.|:||.:.|:.....|:|||:.:..|.|.|.:|:.||.:||.|.:|::||
Human   221 LPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRF 285

  Fly   378 FEEDEDGETVWEAYAKFRESDVHHQYAIVCQTPPYKDKDVDREVNVYIELIRPSDDERSFPALPF 442
            :||:|:| .|||.:..|..:|||.|:|||.:||.|||.::.:..:|:::|.|.||.|.|.|. ||
Human   286 YEEEENG-GVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPK-PF 348

  Fly   443 RYKPR---SVIVSRKRRRT----------GSSANS----------SSSGTESSNNSLDLPKTLGL 484
            .|.|.   ...|.|||::.          ||.|.:          ...||.|:..        |.
Human   349 LYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGP--------GY 405

  Fly   485 AQPPNGLP---NLSQHDQTISEEFGREKHLNEFIASED---------------FRKLIEHNSSDL 531
            :.|..|.|   .::.|..|.....|.:....:..:.:|               |.|:||....|.
Human   406 SFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQ 470

  Fly   532 E-KICQLDMGELQHDGHNRAEVPSHRNRTIKCLDDLF-----EIYKQ------------DRISPI 578
            | ....:..||:     ........:..:....|:||     ::.|:            |....:
Human   471 EPSEATVGNGEV-----TLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLL 530

  Fly   579 KISHHKVEKWFIEHALNNYNRDTLLHEVISHKKDKLKLAIQTIQVMNYFNLKDVVNSTLNADGDS 643
            .:..|..       |:.:.|.|::||..|.|...  :|....::|.:.....|::|.. |....:
Human   531 AVQRHLT-------AVQDENGDSVLHLAIIHLHS--QLVRDLLEVTSGLISDDIINMR-NDLYQT 585

  Fly   644 ALHVACQQDRAHYIRPLLGMGCNPNLKNNAGNTPLHVAVKEEHLSCVESFLNGVPTVQLDLSLTN 708
            .||:|....:...:..||..|.:.:|.:..||:.||:|.||.| ..|.|.|.......|.|...|
Human   586 PLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGH-DKVLSILLKHKKAALLLDHPN 649

  Fly   709 DDGLTPLHMAIRQNKYDVAKKLISYDRTSISVANTMDGNNALHMAVLEQSVEL---LVLILDAQN 770
            .|||..:|:|:..|.......|::.. ..::......|..|||:||...::.|   |:|..||..
Human   650 GDGLNAIHLAMMSNSLPCLLLLVAAG-ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHV 713

  Fly   771 ENLTDILQAQNAAGHTPLELAERKANDRVVQLLKNVYPEKGELAMTWIPCKVKEEIDSSSDESSD 835
            ::.|       ..|.|||.:|..:.:.|:..|||....:  .|...:.|.   .::|.|.:.:.:
Human   714 DSTT-------YDGTTPLHIAAGRGSTRLAALLKAAGAD--PLVENFEPL---YDLDDSWENAGE 766

  Fly   836 AGQLEIKSEEMDIETKDEDSVELDLSSGPRRQKDESSRDTEMDNNKLQLLLKNKFIYDRLCSLLN 900
            ...:...:..:|:.|..:   ..|:.:|...:.:.:|.|.....:..||....|.   :|..||.
Human   767 DEGVVPGTTPLDMATSWQ---VFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKL---QLYKLLE 825

  Fly   901 QPLGHGSDPQDRKWMQLARQTHL----KQFAFIWLGAEDLLDHVKRKGASVE----------FST 951
            .|     || |:.|..||::..|    ..|......::.|:|:.:..|.:|.          ::.
Human   826 IP-----DP-DKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTE 884

  Fly   952 FARALQAVD------PQAYALLVNP 970
            ....:||..      .||::|.::|
Human   885 AIEVIQAASSPVKTTSQAHSLPLSP 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rel	NP_477094.1	RHD-n_Relish	150..336	CDD:143644	69/209 (33%)
		IPT_NFkappaB	343..446	CDD:238582	47/102 (46%)
		ANK	638..766	CDD:238125	38/130 (29%)
		ANK repeat	640..671	CDD:293786	7/30 (23%)
		Ank_4	641..691	CDD:290365	15/49 (31%)
		ANK repeat	673..708	CDD:293786	13/34 (38%)
		Ank_2	678..775	CDD:289560	30/99 (30%)
NFKB1	NP_001369554.1	ANK repeat	685..717	CDD:293786	11/31 (35%)
		Ank_2	690..>733	CDD:423045	15/49 (31%)
		Death_NFkB1_p105	816..891	CDD:260063	17/83 (20%)
		RHD-n_NFkB1	43..244	CDD:143651	69/209 (33%)
		IPT_NFkappaB	251..352	CDD:238582	47/102 (46%)
		Nuclear localization signal. /evidence=ECO:0000255	361..366		3/4 (75%)
		GRR	373..395		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..454		2/27 (7%)
		Interaction with CFLAR. /evidence=ECO:0000269\|PubMed:13679070	436..969		111/515 (22%)
		ANKYR	500..706	CDD:223738	52/217 (24%)
		ANK repeat	543..580	CDD:293786	10/39 (26%)
		ANK repeat	582..613	CDD:293786	7/30 (23%)
		Ank_2	587..681	CDD:403870	28/95 (29%)
		Essential for interaction with HIF1AN. /evidence=ECO:0000269\|PubMed:17003112	651..685		7/34 (21%)
		ANK repeat	651..681	CDD:293786	7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BACK
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3266
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47610
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0004970
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105214
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.880