DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rel and rel

DIOPT Version :9

Sequence 1:	NP_477094.1	Gene:	Rel / 41087	FlyBaseID:	FBgn0014018	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	NP_001001841.2	Gene:	rel / 415101	ZFINID:	ZDB-GENE-040718-255	Length:	596	Species:	Danio rerio

Alignment Length:	374	Identity:	118/374 - (31%)
Similarity:	185/374 - (49%)	Gaps:	44/374 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 QNFGYHQNGLASDGDIKHVPQLRIVEQPVEK-FRFRYKSEMHGTHGSLNGANSKRTPKTFPEVTL 194
            |:...|:     |..:...|.::|.|||.:: .|||||.|.... ||:.|..|....:|:|.:.:
Zfish     4 QSLSMHR-----DPHLMGEPCVQIFEQPKQRGMRFRYKCEGRSA-GSIPGERSSDNNRTYPSIQI 62

  Fly   195 CNYDGPAVIRCSLF-QTNLDSPHSHQLVVRKDDRDVCDPHDLHVSKERGYVAQFINMGIIHTAKK 258
            .|..|...:|.:|. ::....||.|.| |.||.:|  ..::.....||..:| |.|:||....::
Zfish    63 LNVTGKGKVRVTLVTKSEPYKPHPHDL-VGKDCKD--GYYEAEFGPERRAIA-FQNLGIQCVRRR 123

  Fly   259 YIFEELCKKKQDRLVFQMNRRELSHKQLQELHQETEREAKDMNLNQVRLCFEAFKIEDNGAWVPL 323
            .:.:.:    ..|:...:|...:..:||        .:.::.:||.|||||:.:..:::|.:..:
Zfish   124 EVKDAI----MQRVTRGINPFNVPREQL--------LQTEEYDLNVVRLCFQIYLQDESGMYSTM 176

  Fly   324 APPVYSNAINNRKSAQTGELRIVRLSKPTGGVMGNDELILLVEKVSKKNIKVRFFEEDEDGETVW 388
            .||:.||.|.:.::..|.||||.|::|.:|.|.|.||:.||.:||.|.:|:||||.:      .|
Zfish   177 LPPIVSNPIYDNRAPNTAELRICRVNKNSGSVKGGDEIFLLCDKVQKDDIEVRFFTQ------TW 235

  Fly   389 EAYAKFRESDVHHQYAIVCQTPPYKDKDVDREVNVYIELIRPSDDERSFPALPFRYKP--RSVIV 451
            ||...|.::|||.|.|||.:||.|.|..:...|.|.::|.||:|.|.|.| :.|||.|  :....
Zfish   236 EAKGSFSQADVHRQVAIVFKTPAYCDTSITAPVTVRMQLRRPTDQEVSEP-MEFRYLPDDKDPYG 299

  Fly   452 SRKRRR-----TGSSANSSSSGTESSNNSLDLPKTLGL------AQPPN 489
            .|:::|     ..||..|.|....|..|......:..|      .:|||
Zfish   300 CREKKRKIDMQMKSSFPSFSQEAMSFMNRTKAVSSTNLMNQRIKTEPPN 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rel	NP_477094.1	RHD-n_Relish	150..336	CDD:143644	53/187 (28%)
		IPT_NFkappaB	343..446	CDD:238582	47/102 (46%)
		ANK	638..766	CDD:238125
		ANK repeat	640..671	CDD:293786
		Ank_4	641..691	CDD:290365
		ANK repeat	673..708	CDD:293786
		Ank_2	678..775	CDD:289560
rel	NP_001001841.2	RHD-n_c-Rel	18..189	CDD:143649	53/187 (28%)
rel	NP_001001841.2	RHD_dimer	197..293	CDD:292797	46/102 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.980