DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rel and Rela

DIOPT Version :9

Sequence 1:	NP_477094.1	Gene:	Rel / 41087	FlyBaseID:	FBgn0014018	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	NP_954888.1	Gene:	Rela / 309165	RGDID:	727889	Length:	550	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	145/509 - (28%)
Similarity:	213/509 - (41%)	Gaps:	144/509 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 PQLRIVEQPVEK-FRFRYKSEMHGTHGSLNGANSKRTPKTFPEVTLCNYDGPAVIRCSLFQTN-L 212
            |.:.|:|||.:: .|||||.|.... ||:.|..|..|.||.|.:.:..|.||..:|.||...: .
  Rat    19 PYVEIIEQPKQRGMRFRYKCEGRSA-GSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPP 82

  Fly   213 DSPHSHQLVVRKDDRD------VCDPHDLHVSKERGYVAQFINMGIIHTAKKYIFEELCKKKQDR 271
            ..||.|:| |.||.||      :|....:|         .|.|:||           .|.||:|.
  Rat    83 HRPHPHEL-VGKDCRDGFYEAELCPDRCIH---------SFQNLGI-----------QCVKKRDL 126

  Fly   272 LVFQMNRRELSHKQLQELHQETEREAKDMNLNQVRLCFEAFKIEDNGAWVPLAPPVYSNAINNRK 336
            ......|.:.::...|   ...|.:..|.:||.|||||:....:.:|..:.|. ||.|:.|.:.:
  Rat   127 EQAISQRIQTNNNPFQ---VPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLT-PVLSHPIFDNR 187

  Fly   337 SAQTGELRIVRLSKPTGGVMGNDELILLVEKVSKKNIKVRFFEEDEDGETVWEAYAKFRESDVHH 401
            :..|.||:|.|:::.:|..:|.||:.||.:||.|::|:|.|....      |||...|.::|||.
  Rat   188 APNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPG------WEARGSFSQADVHR 246

  Fly   402 QYAIVCQTPPYKDKDVDREVNVYIELIRPSDDERSFPALPFRYKPRS---VIVSRKRRRTGSS-- 461
            |.|||.:||||.|..:...|.|.::|.||||.|.|.| :.|:|.|.:   ..:..||:||..:
  Rat   247 QVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEP-MEFQYLPDTDDRHRIEEKRKRTYETFK 310

  Fly   462 ---------------------------------------ANSSSSGT--------------ESSN 473
                                                   |.|:|..|              :.||
  Rat   311 SIMKKSPFNGPTEPRPPPRRIAVPSRGPTSVPKPAPQPYAFSTSLSTINFDEFSPMVLPPGQISN 375

  Fly   474 NSLDL-------------PKTL---GLAQPPNGLPNLS----------------QHDQTISEEFG 506
            .:|.|             |.:.   .|||||..:|.|:                ..:.|:||..
  Rat   376 QALALAPSSAPVLAQTMVPSSAMVPSLAQPPAPVPVLAPGPPQSLSAPVPKSTQAGEGTLSEAL- 439

  Fly   507 REKHLNEFIASEDFRKLIEHNS-----SDLEKICQLDMGELQHDG----HNRAE 551
              .|| :|.|.||...|:.:|:     :||..:...:..:|.:.|    |:.||
  Rat   440 --LHL-QFDADEDLGALLGNNTDPGVFTDLASVDNSEFQQLLNQGVAMSHSTAE 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rel	NP_477094.1	RHD-n_Relish	150..336	CDD:143644	61/193 (32%)
		IPT_NFkappaB	343..446	CDD:238582	43/102 (42%)
		ANK	638..766	CDD:238125
		ANK repeat	640..671	CDD:293786
		Ank_4	641..691	CDD:290365
		ANK repeat	673..708	CDD:293786
		Ank_2	678..775	CDD:289560
Rela	NP_954888.1	RHD-n_RelA	19..187	CDD:143645	61/193 (32%)
Rela	NP_954888.1	IPT_NFkappaB	194..290	CDD:238582	43/102 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.980