DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rel and Rel

DIOPT Version :9

Sequence 1:	NP_477094.1	Gene:	Rel / 41087	FlyBaseID:	FBgn0014018	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	XP_008768670.2	Gene:	Rel / 305584	RGDID:	1311231	Length:	595	Species:	Rattus norvegicus

Alignment Length:	665	Identity:	170/665 - (25%)
Similarity:	262/665 - (39%)	Gaps:	199/665 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 LASDGDIKHVPQLRIVEQPVEK-FRFRYKSEMHGTHGSLNGANSKRTPKTFPEVTLCNYDGPAVI 203
            :||.|   :.|.:.|:|||.:: .|||||.|.... ||:.|..|....:|:|.:.:.||.|...:
  Rat     1 MASSG---YNPYVEIIEQPRQRGMRFRYKCEGRSA-GSIPGERSTDNNRTYPSIQIMNYYGKGKV 61

  Fly   204 RCSLFQTNLD--SPHSHQLVVRKDDRDVCDPHDLHVSKERGYVAQFINMGIIHTAKKYIFEELCK 266
            |.:|...| |  .||.|.| |.||.||  ..::.....||..:. |.|:||....||.:.|.:..
  Rat    62 RITLVTKN-DPYKPHPHDL-VGKDCRD--GYYEAEFGPERRPLF-FQNLGIRCVKKKEVKEAIIL 121

  Fly   267 KKQDRLVFQMNRRELSHKQLQELHQETEREAKDMNLNQVRLCFEAFKIEDNGAWVPLAPPVYSNA 331
                |:...:|...:..:||.::        :|.:||.|||||:.|..:::|.:....||:.||.
  Rat   122 ----RISAGINPFNVPEQQLLDI--------EDCDLNVVRLCFQVFLPDEHGNFTTALPPIVSNP 174

  Fly   332 INNRKSAQTGELRIVRLSKPTGGVMGNDELILLVEKVSKKNIKVRFFEEDEDGETVWEAYAKFRE 396
            |.:.::..|.||||.|::|..|.|.|.||:.||.:||.|.:|:|||...|      |||...|.:
  Rat   175 IYDNRAPNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLND------WEAKGIFSQ 233

  Fly   397 SDVHHQYAIVCQTPPYKDKDVDREVNVYIELIRPSDDERSFPALPFRYKP--------------- 446
            :|||.|.|||.:|||| .:.:...|.|.::|.||||.|.| .::.|||.|
  Rat   234 ADVHRQVAIVFRTPPY-CRAIVEPVTVKMQLRRPSDQEVS-ESMDFRYLPDEKDAYGNKSKKQKT 296

  Fly   447 ------------RSVIVSRKRRRTGS--------------SANSSSSGTESSNNSLDLPKT---- 481
                        :.:|.|....:|.:              .:|..|.||.       ||:|
  Rat   297 TLIFQKLLQDCEKRIIPSHFPEKTRAVPLESIGETRFIKKESNLFSHGTV-------LPETPRSS 354

  Fly   482 --LGLAQP---------------PNGLPNLSQHDQTIS------EEFGREKHLNEFIASEDFRKL 523
              .|.|:|               |:.:|::.....:.|      ...|....|:.|.|.:    |
  Rat   355 GVPGQAEPYYSSSGSISNALPHHPSAMPSMVHQPASWSPVTHPTSHPGSTNTLSSFPAGQ----L 415

  Fly   524 IEHNSSDLEKICQLDMGEL--------QHDGHNRAEVPSHRNRTIKCLDDLFEIYKQDRIS--PI 578
            ..::...|..:....|.:|        ..|...|.|.||      ....||:.|...:.::  |:
  Rat   416 SSNSQGVLPFLDGAGMNDLSASNACLFSTDNLARMETPS------MSPTDLYSISDVNMLTNRPV 474

  Fly   579 KI-----------SHHKVEKWFIEHALNNYNRDTLLHEVISHKKDKLKLAIQTIQVMNYFNLKDV 632
            .:           .|.::....:|:...|...|         .:|..:             |..:
  Rat   475 SVMTSSTDGMGDTDHPRLVSVNLENPSCNSRLD---------PRDPRQ-------------LHQM 517

  Fly   633 VNSTLNADGDSALHVACQQDRAHYIRPLLGMGCNPNLKNNAGNTPLHVAVKEEHLSCVESFLNGV 697
            ..::::|.|.|:..|...|                   ::..|.|        |.||::   ||
  Rat   518 STASMSAAGTSSSSVFVSQ-------------------SDTFNRP--------HFSCID---NG- 551

  Fly   698 PTVQLDLSLTNDDGL 712
                    |||:.||
  Rat   552 --------LTNEPGL 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rel	NP_477094.1	RHD-n_Relish	150..336	CDD:143644	61/188 (32%)
		IPT_NFkappaB	343..446	CDD:238582	47/102 (46%)
		ANK	638..766	CDD:238125	17/75 (23%)
		ANK repeat	640..671	CDD:293786	4/30 (13%)
		Ank_4	641..691	CDD:290365	9/49 (18%)
		ANK repeat	673..708	CDD:293786	8/34 (24%)
		Ank_2	678..775	CDD:289560	10/35 (29%)
Rel	XP_008768670.2	RHD-n_c-Rel	8..179	CDD:143649	55/173 (32%)
Rel	XP_008768670.2	RHD_dimer	187..282	CDD:406564	41/94 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020