DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rel and Nfkb2

DIOPT Version :9

Sequence 1:NP_477094.1 Gene:Rel / 41087 FlyBaseID:FBgn0014018 Length:971 Species:Drosophila melanogaster
Sequence 2:NP_001170841.1 Gene:Nfkb2 / 18034 MGIID:1099800 Length:900 Species:Mus musculus


Alignment Length:931 Identity:238/931 - (25%)
Similarity:370/931 - (39%) Gaps:261/931 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 PAPATVPPSQNFGYHQNGLASDGDIKHVPQLRIVEQPVEK-FRFRYKSEMHGTHGSLNGANSKRT 185
            |||.|               :||     |.|.|||||.:: |||||..| ..:||.|.||:|::.
Mouse    30 PAPET---------------ADG-----PYLVIVEQPKQRGFRFRYGCE-GPSHGGLPGASSEKG 73

  Fly   186 PKTFPEVTLCNYDGPAVIRCSLFQTNLDSP--HSHQLVVRK-DDRDVC----DPHDLHVSKERGY 243
            .||:|.|.:|||:|||.|...|. |:.|.|  |:|.||.:: .:..||    .|.|:        
Mouse    74 RKTYPTVKICNYEGPAKIEVDLV-THSDPPRAHAHSLVGKQCSELGVCAVSVGPKDM-------- 129

  Fly   244 VAQFINMGIIHTAKKYIFEELCKKKQDRLVFQMNRRELSHKQLQELHQETEREAKDMNLNQVRLC 308
            .|||.|:|::|..||.:.|.:.:|.| |...:...:.|:..:.:||.||.:...|.|:|:.|||.
Mouse   130 TAQFNNLGVLHVTKKNMMEIMIQKLQ-RQRLRSKPQGLTEAERRELEQEAKELKKVMDLSIVRLR 193

  Fly   309 FEAFKIEDNGAW-VPLAPPVYSNAINNRKSAQTGELRIVRLSKPTGGVMGNDELILLVEKVSKKN 372
            |.||....:|:: :|| .||.|..|::.||.....|:|.|:.|..|.|.|.||:.||.:||.|.:
Mouse   194 FSAFLRASDGSFSLPL-KPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDD 257

  Fly   373 IKVRFFEEDEDGETVWEAYAKFRESDVHHQYAIVCQTPPYKDKDVDREVNVYIELIRPS----DD 433
            |:|||:|:||:|   |:|:..|..:|||.|||||.:||||....::|.|.|:::|.|..    .|
Mouse   258 IEVRFYEDDENG---WQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSD 319

  Fly   434 ERSFPALPFRYKPRSVIVSRKRRRT----------------GSSANSSSSGTESSNNSLDL---- 478
            .:.|...|.......  |.||||:.                ||..::...|......||..    
Mouse   320 SKQFTYYPLVEDKEE--VQRKRRKALPTFSQPFGGGSHMGGGSGGSAGGYGGAGGGGSLGFFSSS 382

  Fly   479 ----PKTLGL---------------------------AQPPNGLPNLSQHDQTISEEFGREKHLN 512
                |...|.                           |:.|...|...|.:....:...|.:..|
Mouse   383 LAYNPYQSGAAPMGCYPGGGGGAQMAGSRRDTDAGEGAEEPRTPPEAPQGEPQALDTLQRAREYN 447

  Fly   513 E---FIASEDFRKLIEHN-SSDLEKICQLDMGELQHDGHNRAEVPSHRNRTIKCLDDLFEIYKQD 573
            .   .:|....|.|:::. ::|.                 ||.:...|:.          :..||
Mouse   448 ARLFGLAQRSARALLDYGVTADA-----------------RALLAGQRHL----------LMAQD 485

  Fly   574 RISPIKISHHKVEKWFIEHALNNYNRDTLLHEVISHKK----DKLKLAIQTIQVMNYFNLKDVVN 634
            .                       |.||.||..|.|.:    :::...|...|.:...||.:.::
Mouse   486 E-----------------------NGDTPLHLAIIHGQTGVIEQIAHVIYHAQYLGVINLTNHLH 527

  Fly   635 STLNADGDSALHVACQQDRAHYIRPLLGMGCNPNLKNNAGNTPLHVAVK------EEHLSCVESF 693
            .|       .||:|....:...:..||.:|.:|.|.:..|::.||:|::      |...:.:.|.
Mouse   528 QT-------PLHLAVITGQTRVVSFLLQVGADPTLLDRHGDSALHLALRAGAAAPELLQALLRSG 585

  Fly   694 LNGVPTVQLDLSLTNDDGLTPLHMAIRQNKYDVAKKLISYDRTSISVANTMDGNNALHMAVLEQS 758
            .:.||.:   |.:.:.:||.|:|:|:.....:....|:... ..:.......|..|||:|...:.
Mouse   586 AHAVPQI---LHMPDFEGLYPVHLAVHARSPECLDLLVDCG-AEVEAPERQGGRTALHLATEMEE 646

  Fly   759 VELLVLILDAQNENLTDILQAQNAAGHTPLELAERKANDRVVQLL----KNVYPEKGELAMTWIP 819
            :.|:..::...:.|    :.|:..||:|||.||....:..:.:||    .:::.|..|      |
Mouse   647 LGLVTHLVTKLHAN----VNARTFAGNTPLHLAAGLGSPTLTRLLLKAGADIHAENEE------P 701

  Fly   820 -CKVKEEIDSSSDESSDAGQLEIKSEEMDIETKDEDSVELDLSSGPRRQKDESSR-DTEMD---N 879
             |.:.....|.||..|:                           ||.|....:.| .|.:|   :
Mouse   702 LCPLPSPSTSGSDSDSE---------------------------GPERDTQRNFRGHTPLDLTCS 739

  Fly   880 NKLQLLLKN-----------------------KFIYDRLCSLLNQPLGHGSDPQDRKWMQLARQT 921
            .|::.||.|                       ......|..||:.|...||      |.:||.: 
Mouse   740 TKVKTLLLNAAQNTTEPPLAPPSPAGPGLSLGDAALQNLEQLLDGPEAQGS------WAELAER- 797

  Fly   922 HLKQFAFIWLGAEDLLDHVKR 942
                     ||...|:|..::
Mouse   798 ---------LGLRSLVDTYRK 809

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RelNP_477094.1 RHD-n_Relish 150..336 CDD:143644 75/194 (39%)
IPT_NFkappaB 343..446 CDD:238582 45/106 (42%)
ANK 638..766 CDD:238125 29/133 (22%)
ANK repeat 640..671 CDD:293786 8/30 (27%)
Ank_4 641..691 CDD:290365 13/55 (24%)
ANK repeat 673..708 CDD:293786 9/40 (23%)
Ank_2 678..775 CDD:289560 21/102 (21%)
Nfkb2NP_001170841.1 RHD-n_NFkB2 38..221 CDD:143650 75/194 (39%)
IPT_NFkappaB 228..327 CDD:238582 44/101 (44%)
Nuclear localization signal. /evidence=ECO:0000255 337..341 3/3 (100%)
GRR 346..377 4/30 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 403..434 4/30 (13%)
PHA03095 459..>705 CDD:222980 64/316 (20%)
ANK repeat 487..524 CDD:293786 11/36 (31%)
ANK 1 487..516 8/28 (29%)
ANK repeat 526..557 CDD:293786 9/37 (24%)
ANK 2 526..555 8/35 (23%)
ANK 3 559..590 6/30 (20%)
ANK repeat 559..586 CDD:293786 6/26 (23%)
ANK repeat 599..630 CDD:293786 6/31 (19%)
ANK 4 599..628 6/29 (21%)
ANK repeat 633..665 CDD:293786 8/35 (23%)
ANK 5 633..663 7/33 (21%)
ANK repeat 667..698 CDD:293786 9/30 (30%)
ANK 6 667..696 9/28 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 698..734 12/68 (18%)
ANK 7 729..755 7/25 (28%)
Death_NFkB2_p100 774..849 CDD:176776 13/52 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BACK
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 256 1.000 Inparanoid score I3150
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47610
OrthoDB 1 1.010 - - D391433at33208
OrthoFinder 1 1.000 - - FOG0004970
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_105214
Panther 1 1.100 - - O PTHR24169
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6960
SonicParanoid 1 1.000 - - X100
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1110.910

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