DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rel and Nfkb1

DIOPT Version :9

Sequence 1:	NP_477094.1	Gene:	Rel / 41087	FlyBaseID:	FBgn0014018	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	NP_032715.2	Gene:	Nfkb1 / 18033	MGIID:	97312	Length:	971	Species:	Mus musculus

Alignment Length:	930	Identity:	252/930 - (27%)
Similarity:	403/930 - (43%)	Gaps:	192/930 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 LASDGDIKHVPQLRIVEQPVEK-FRFRYKSEMHGTHGSLNGANSKRTPKTFPEVTLCNYDGPAVI 203
            |::||     |.|:|:|||.:: |||||..| ..:||.|.||:|::..|::|:|.:|||.|||.:
Mouse    35 LSTDG-----PYLQILEQPKQRGFRFRYVCE-GPSHGGLPGASSEKNKKSYPQVKICNYVGPAKV 93

  Fly   204 RCSLFQTNLD-SPHSHQLVVRKDDRDVC----DPHDLHVSKERGYVAQFINMGIIHTAKKYIFEE 263
            ...|.....: ..|:|.||.:..:..||    .|.|:        |..|.|:||:|..||.:||.
Mouse    94 IVQLVTNGKNIHLHAHSLVGKHCEDGVCTVTAGPKDM--------VVGFANLGILHVTKKKVFET 150

  Fly   264 LCKKKQDRLVFQMNRRELSHKQLQELHQE-------TERE-----------AKDMNLNQVRLCFE 310
            |..:..:..:...|...|.|..|..|..|       |:||           .|:|:|:.|||.|.
Mouse   151 LEARMTEACIRGYNPGLLVHSDLAYLQAEGGGDRQLTDREKEIIRQAAVQQTKEMDLSVVRLMFT 215

  Fly   311 AFKIEDNGAWVPLAPPVYSNAINNRKSAQTGELRIVRLSKPTGGVMGNDELILLVEKVSKKNIKV 375
            ||..:..|::.....||.|:||.:.|:.....|:|||:.:..|.|.|.:|:.||.:||.|.:|::
Mouse   216 AFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQI 280

  Fly   376 RFFEEDEDGETVWEAYAKFRESDVHHQYAIVCQTPPYKDKDVDREVNVYIELIRPSDDERSFPAL 440
            ||:||:|:| .|||.:..|..:|||.|:|||.:||.|||.::.:..:|:::|.|.||.|.|.|.
Mouse   281 RFYEEEENG-GVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPK- 343

  Fly   441 PFRYKPR---SVIVSRKRRRT----------GSSANSSSSGTESS---NNSLDLP------KTLG 483
            ||.|.|.   ...|.|||::.          ||.|.:...|...|   ..|...|      ...|
Mouse   344 PFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYG 408

  Fly   484 LAQPPNG----LPNLSQHDQTISEEFGREKHLNEFIASEDFRKLIEHNSSDLEKICQLDMGELQH 544
            .  ||.|    .|.:::.:..::......|..|   ..:|..|      ||.|:...|...|.:.
Mouse   409 F--PPYGGITFHPGVTKSNAGVTHGTINTKFKN---GPKDCAK------SDDEESLTLPEKETEG 462

  Fly   545 DGHNRAEVPSHRNRTIKCLDDLFEIYKQDRISPIKISHHKVEK---------WFIEHALNNYNRD 600
            :|   ..:|....:|                .||.::....:|         .|:|.||....|.
Mouse   463 EG---PSLPMACTKT----------------EPIALASTMEDKEQDMGFQDNLFLEKALQLARRH 508

  Fly   601 -TLLHEVISHKKDKLKLAIQTIQVMNYFNLKDVVNSTLNADGDSALHVACQQDRAHYIRPLL--- 661
             ..|.:.......|:.||:|.           .:.:..:.:|||.||:|.....|..:|.||
Mouse   509 ANALFDYAVTGDVKMLLAVQR-----------HLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVT 562

  Fly   662 -GMGCNP--NLKNNAGNTPLHVAVKEEHLSCVESFLNGVPTVQLDLSLTNDDGLTPLHMAIRQNK 723
             |:..:.  |::|:...||||:||..:....||..|.    |..||||.:..|.:.||:|.::.
Mouse   563 SGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLR----VGADLSLLDRWGNSVLHLAAKEG- 622

  Fly   724 YDVAKKLISYDRTSISVANTMD-----GNNALHMAVLEQSVELLVLILDA--------------- 768
            :|   :::|....|...|..:|     |.||:|:||:..|:..|:|::.|
Mouse   623 HD---RILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSGRTA 684

  Fly   769 -------QNENLTDILQAQNAA--------GHTPLELAERKANDRVVQLLKNVYPEKGELAMTWI 818
                   .|.:|...|..:..|        |.|||.:|..:.:.|:..|||....:  .|...:.
Mouse   685 LHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGAD--PLVENFE 747

  Fly   819 PCKVKEEIDSSSDESSDAGQLEIKSEEMDIETKDEDSVELDLSSGPRRQKDESSRDTEMDNNKLQ 883
            |.   .::|.|.:::.:...:...:..:|:....:   ..|:.:|...:...:|.|.....:..|
Mouse   748 PL---YDLDDSWEKAGEDEGVVPGTTPLDMAANWQ---VFDILNGKPYEPVFTSDDILPQGDMKQ 806

  Fly   884 LLLKNKFIYDRLCSLLNQPLGHGSDPQDRKWMQLARQTHL----KQFAFIWLGAEDLLDHVKRKG 944
            |....:.   :||.||..|     || |:.|..||::..|    ..|......::.|:|:.:..|
Mouse   807 LTEDTRL---QLCKLLEIP-----DP-DKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSG 862

  Fly   945 ASVEFSTFARALQAVDPQAY 964
            .:::     ..::|:....|
Mouse   863 GTIK-----ELMEALQQMGY 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rel	NP_477094.1	RHD-n_Relish	150..336	CDD:143644	71/209 (34%)
		IPT_NFkappaB	343..446	CDD:238582	47/102 (46%)
		ANK	638..766	CDD:238125	45/138 (33%)
		ANK repeat	640..671	CDD:293786	12/36 (33%)
		Ank_4	641..691	CDD:290365	19/55 (35%)
		ANK repeat	673..708	CDD:293786	14/34 (41%)
		Ank_2	678..775	CDD:289560	33/123 (27%)
Nfkb1	NP_032715.2	RHD-n_NFkB1	40..241	CDD:143651	71/209 (34%)
		IPT_NFkappaB	248..349	CDD:238582	47/102 (46%)
		Nuclear localization signal. /evidence=ECO:0000255	358..363		3/4 (75%)
		GRR	370..392		5/21 (24%)
		Interaction with CFLAR. /evidence=ECO:0000250	433..971		113/514 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..470		10/42 (24%)
		ANK repeat	538..575	CDD:293786	12/36 (33%)
		Ank_4	539..598	CDD:290365	21/58 (36%)
		ANK	572..701	CDD:238125	37/136 (27%)
		ANK repeat	577..608	CDD:293786	14/34 (41%)
		Ank_2	582..676	CDD:289560	31/101 (31%)
		Essential for interaction with HIF1AN. /evidence=ECO:0000250	646..680		10/33 (30%)
		ANK repeat	646..677	CDD:293786	10/30 (33%)
		Ank_5	666..722	CDD:290568	9/55 (16%)
		ANK repeat	680..712	CDD:293786	4/31 (13%)
		Death_NFkB1_p105	812..886	CDD:260063	18/80 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BACK
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3150
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47610
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004970
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105214
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870