DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rel and Relb

DIOPT Version :9

Sequence 1:	NP_477094.1	Gene:	Rel / 41087	FlyBaseID:	FBgn0014018	Length:	971	Species:	Drosophila melanogaster
Sequence 2:	XP_008757276.1	Gene:	Relb / 100360982	RGDID:	2321078	Length:	559	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	135/394 - (34%)
Similarity:	181/394 - (45%)	Gaps:	59/394 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 PAPATVPPSQNFGYHQNGLASDGDIKHVPQLRIVEQPVEK-FRFRYKSEMHGTHGSLNGANSKRT 185
            |.|||.|.:...|    .|.|.|.... |.|.|.|||.:: .||||:.|.... ||:.|.:|...
  Rat    81 PPPATPPWNCTLG----RLVSPGPCPR-PYLVITEQPKQRGMRFRYECEGRSA-GSILGESSTEA 139

  Fly   186 PKTFPEVTLCNYDG---PAVIRCSLFQTNLDSPHSHQLVVRKDDRDVC----DPHDLHVSKERGY 243
            .||.|.:.|.:..|   ..|..|.:::......|.|.||.:.....||    .|   |||...
  Rat   140 SKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCTDGVCRVRLRP---HVSPRH-- 199

  Fly   244 VAQFINMGIIHTAKKYIFEELCKKKQDRLVFQMNRRELSHKQLQELHQETEREAKDMNLNQVRLC 308
              .|.|:||....||.| |...::|....:...|...|.:      |||.     |||:  ||:|
  Rat   200 --SFNNLGIQCVRKKEI-EAAIERKIQLGIDPYNAGSLKN------HQEV-----DMNV--VRIC 248

  Fly   309 FEAFKIEDNGAWVPLAPPVYSNAINNRKSAQTGELRIVRLSKPTGGVMGNDELILLVEKVSKKNI 373
            |:| ...|....:....|:.|..:.::||..|.||||.|::|.:|...|.:||.||.:||.|::|
  Rat   249 FQA-SYRDQQGHLHRMDPILSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKEDI 312

  Fly   374 KVRFFEEDEDGETVWEAYAKFRESDVHHQYAIVCQTPPYKDKDVDREVNVYIELIRPSDDERSFP 438
            .|.|      ....||..|.|.::|||.|.|||.:||||:|.::...|.|.:.|.|.:|...|.|
  Rat   313 SVVF------STASWEGRADFSQADVHRQIAIVFKTPPYEDLEISEPVTVNVFLQRLTDGVCSEP 371

  Fly   439 ALPFRYKPR---SVIVSRKRRR-----TGSSANSSSSGTESSNNS-----LD--LP-KTLGLAQP 487
             |||.|.||   |..|.:||:|     .|..::|...|.||....     ||  || .:.||..|
  Rat   372 -LPFTYLPRDHDSYGVDKKRKRGLPDVLGELSSSDPHGIESKRRKKKPVFLDHFLPGHSSGLFLP 435

  Fly   488 PNGL 491
            |:.|
  Rat   436 PSAL 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rel	NP_477094.1	RHD-n_Relish	150..336	CDD:143644	57/193 (30%)
		IPT_NFkappaB	343..446	CDD:238582	44/102 (43%)
		ANK	638..766	CDD:238125
		ANK repeat	640..671	CDD:293786
		Ank_4	641..691	CDD:290365
		ANK repeat	673..708	CDD:293786
		Ank_2	678..775	CDD:289560
Relb	XP_008757276.1	RelB_leu_zip	1..76	CDD:292798
		RHD-n_RelB	104..275	CDD:143646	57/193 (30%)
		RHD_dimer	283..379	CDD:292797	43/102 (42%)
		RelB_transactiv	382..559	CDD:292799	19/58 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.980