DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyx and PHP

DIOPT Version :9

Sequence 1:	NP_001163564.1	Gene:	hyx / 41086	FlyBaseID:	FBgn0037657	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_188898.1	Gene:	PHP / 821831	AraportID:	AT3G22590	Length:	415	Species:	Arabidopsis thaliana

Alignment Length:	547	Identity:	145/547 - (26%)
Similarity:	228/547 - (41%)	Gaps:	159/547 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DPLSLLRQYNINKK-EIVER-DSQIIFG-EFSWPKSVKTNYLKYGSGKKGAPREYYTLECLLYLL 64
            ||||:|:::.|... :.:|| .:...|| |:|:|.:.:|.|    ..|.|:   .||||.|::.:
plant     2 DPLSVLKEFTIRGDIDKIERVGANYRFGSEYSFPCATETAY----RSKSGS---LYTLEALVHYV 59

  Fly    65 KNVMLQHSVYVRQCAAEDIPAVNRPDRKELLAYLNGETPTCASIDKSAPLEIPTQVKRAAEGEPS 129
            ||..|:|..|::......:|||..||||.||.||.|...:..|||
plant    60 KNQQLKHGEYMQSTVKNSVPAVTLPDRKPLLDYLTGRVASSDSID-------------------- 104

  Fly   130 SVEVAAKKARFEETQVQKVREQLAARWDVNQKETAVNMDNIKSLSETMSVEKIAAIKAKRLANKR 194
                      |...|.|..:.|      ...:|...:.||...:|...::..:..
plant   105 ----------FLLLQQQNAQSQ------KQNEEYRPDQDNSAFVSRENAIADMEV---------- 143

  Fly   195 TTIKRTDNDEAMGTDLRAILDYDVDSTKDIISRERQWRTRTSILQSTGKIFAKNIFAMLQGIKAR 259
                     |..|..     ..|||....|.|.||..::|.:|||...:.|    :::|.....|
plant   144 ---------EDFGKS-----GEDVDYIMLIRSNERPLKSRDAILQCKNRDF----YSVLVNSTKR 190

  Fly   260 EEGRNRPQVPNPIKMPEPARIAKPQPQLSQYNRYDQERFNRQKEETEGFKIDTLGTYHGMSLKSV 324
            ||.|.|                     :..:.|.|                       |:..||
plant   191 EEERQR---------------------IESHQRKD-----------------------GLVAKS- 210

  Fly   325 TEGSLAQRKAQANNLPGAP--GVIAGAAAGRPKELLPAAQARQLPANGPSKRTSR-------TPI 380
                         .|.||.  |::..::.|        .......||..||...:       .||
plant   211 -------------RLMGAEERGIVGFSSGG--------GDDNGYDANPKSKLHFKAGKIGEGVPI 254

  Fly   381 IIIPSANTSLITMLNAKDILQELRFM--STSDKKLQGCQRECEVLLQRK----RNNQTVSYRVID 439
            |::|||..:|||:.|.|:.|::..::  ....|:::|.:.:| :.:|:|    |.....:|.|.|
plant   255 ILVPSAFQTLITIYNVKEFLEDGVYIPNDVKAKEMKGLKPDC-ITVQKKFSRDRERVVTAYEVRD 318

  Fly   440 NPTKLSQQEWQRVVAVFVMGPQWQFKGWPWEGNPVDIFSKICAFHLCFSEMKLDS--NVERWSVT 502
            .|:.|...:|.|||||||:|..||||.||::.: |:||:||..|.|.|.:..::|  .|::|:|.
plant   319 KPSALKPDDWDRVVAVFVLGKDWQFKDWPFKDH-VEIFNKIIGFFLRFEDDSIESAKTVKQWNVK 382

  Fly   503 LLRLSQNKRHMDRAVLSKFWETLDKYI 529
            ::.:|:||||.|||...:.||.|::::
plant   383 IISISKNKRHQDRAAALEVWEKLEEFV 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyx	NP_001163564.1	CDC73_N	1..297	CDD:292669	72/296 (24%)
hyx	NP_001163564.1	CDC73_C	376..527	CDD:282965	61/165 (37%)
PHP	NP_188898.1	CDC73	31..412	CDD:227486	135/518 (26%)
PHP	NP_188898.1	CDC73_C	252..407	CDD:398719	61/156 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	118	1.000	Domainoid score	I1938
eggNOG	1	0.900	-	-		E1_COG5157
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11571
Inparanoid	1	1.050	184	1.000	Inparanoid score	I1421
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D720340at2759
OrthoFinder	1	1.000	-	-		FOG0004392
OrthoInspector	1	1.000	-	-		otm3413
orthoMCL	1	0.900	-	-		OOG6_102858
Panther	1	1.100	-	-	LDO	PTHR12466
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4776
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830