Protein Alignment hyx and CDC73

DIOPT Version :10

• Sequence 1: NP_649863.1
• Gene: hyx / 41086
• FlyBaseID: FBgn0037657
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_078805.3
• Gene: CDC73 / 79577
• HGNCID: 16783
• Length: 531
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 323/555 - (58%)
• Similarity: 399/555 - (71%)
• Gaps: 41/555 - (7%)

  Fly     1 MADPLSLLRQYNINKKEIVERDSQIIFGEFSWPKSVKTNYLKYGSGKKGAPREYYTLECLLYLLK 65
            |||.||:||||||.|||||.:..::|||||||||:|||||:.:|:||:|.|||||||:.:|:||.
Human     1 MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLN 65

  Fly    66 NVMLQHSVYVRQCAAEDIPAVNRPDRKELLAYLNGETPTCASIDKSAPLEI----PTQVKRAAEG 126
            ||.|.|.||||:.|.|:||.|.|||||:||.|||||..|.||||:||||||    .|||||||:
Human    66 NVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAAD- 129

  Fly   127 EPSSVEVAAKKARFEETQ-VQKVREQLAARWDVNQKETAVNMDNIKSLSETMSVEKIAAIKAKRL 190
               .|...|||.|.|:.: |:..:|:||||.: ..||..|..:.|:||||.||||||||||||.:
Human   130 ---EVLAEAKKPRIEDEECVRLDKERLAARLE-GHKEGIVQTEQIRSLSEAMSVEKIAAIKAKIM 190

  Fly   191 ANKRTTIKRTDNDEAMGTDLRAILDYDVDSTKDIISRERQWRTRTSILQSTGKIFAKNIFAMLQG 255
            |.||:|||...:|:......|:.:|.:||.|:||:||||.|||||:|||||||.|:|||||:||.
Human   191 AKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQS 255

  Fly   256 IKAREEGRNRPQVPNPIKMPEPARIAKPQPQLSQYNRYDQERFNRQKEETEGFKIDTLGTYHGMS 320
            :|||||||...|.|.|...|....:...||..:.||||||||| :.|||||||||||:||||||:
Human   256 VKAREEGRAPEQRPAPNAAPVDPTLRTKQPIPAAYNRYDQERF-KGKEETEGFKIDTMGTYHGMT 319

  Fly   321 LKSVTEGSLAQRKAQANNLPGAPGVIAGAAAGRPKELLPAAQARQLPANGPSKRTSRTPIIIIPS 385
            |||||||:.| ||.|.   |.|..|        |:   |.:|||. |.|  .|:.|||||||||:
Human   320 LKSVTEGASA-RKTQT---PAAQPV--------PR---PVSQARP-PPN--QKKGSRTPIIIIPA 366

  Fly   386 ANTSLITMLNAKDILQELRFMSTSDKKLQGCQRECEVLLQRKRNNQ---------TVSYRVIDNP 441
            |.|||||||||||:||:|:|:.:.:||.||||||.|.|:||:::..         ||.|||:|.|
Human   367 ATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQP 431

  Fly   442 TKLSQQEWQRVVAVFVMGPQWQFKGWPW---EGNPVDIFSKICAFHLCFSEMKLDSNVERWSVTL 503
            .||..|:|.|||||||.||.||||||||   :|:|||||:||.||||.:.|::||.||::|.||:
Human   432 LKLMPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTV 496

  Fly   504 LRLSQNKRHMDRAVLSKFWETLDKYIAKYKPDLRY 538
            |.||.:|||:||.|..:||||||:|:.|:|..||:
Human   497 LELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hyx	NP_649863.1	CDC73_N	1..297	CDD:464994	176/300 (59%)
		CDC73_C	376..527	CDD:461570	99/162 (61%)
CDC73	NP_078805.3	CDC73_N	1..297	CDD:464994	176/300 (59%)
		Nuclear localization signal	125..139		8/17 (47%)
		Interaction with POLR2A and PAF1	200..531		197/349 (56%)
		Interaction with CTNNB1. /evidence=ECO:0000269|PubMed:16630820	200..250		27/49 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..292		11/31 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..358		17/50 (34%)
		CDC73_C	357..520	CDD:461570	99/162 (61%)