DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyx and cdc73

DIOPT Version :9

Sequence 1:	NP_001163564.1	Gene:	hyx / 41086	FlyBaseID:	FBgn0037657	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001278325.1	Gene:	cdc73 / 393319	ZFINID:	ZDB-GENE-040426-1309	Length:	530	Species:	Danio rerio

Alignment Length:	557	Identity:	321/557 - (57%)
Similarity:	407/557 - (73%)	Gaps:	46/557 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADPLSLLRQYNINKKEIVERDSQIIFGEFSWPKSVKTNYLKYGSGKKGAPREYYTLECLLYLLK 65
            |||.||:||||||.|||||.:..::|||||||||:|||||:.:|:||:|.|:|||||:.:|:||.
Zfish     1 MADVLSVLRQYNIQKKEIVAKGDEVIFGEFSWPKNVKTNYVIWGTGKEGQPKEYYTLDSILFLLN 65

  Fly    66 NVMLQHSVYVRQCAAEDIPAVNRPDRKELLAYLNGETPTCASIDKSAPLEI----PTQVKRAAEG 126
            ||.|.|..|||:.|.|:||.|.|||||:||:|||||:.:..|||:|||:||    ||||||||:
Zfish    66 NVHLPHPSYVRRAATENIPVVRRPDRKDLLSYLNGESSSSTSIDRSAPIEIGLQRPTQVKRAAD- 129

  Fly   127 EPSSVEVAAKKARFE-ETQVQKVREQLAARWDVNQKETAVNMDNIKSLSETMSVEKIAAIKAKRL 190
               .|...|||.|.| |.:|:..:|:||||.: ..||:.|..|.|:||||.||||||||||||.:
Zfish   130 ---EVSSEAKKPRVEDEERVRLDKERLAARLE-GHKESIVQTDQIRSLSEAMSVEKIAAIKAKIM 190

  Fly   191 ANKRTTIKRTDNDEAMGTDLRAILDYDVDSTKDIISRERQWRTRTSILQSTGKIFAKNIFAMLQG 255
            |.||:||| ||.|:.:....|:.:|.:||.|:||:||||.|||||:||||:||.|:|||||:||.
Zfish   191 AKKRSTIK-TDLDDDITQKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSSGKNFSKNIFAILQS 254

  Fly   256 IKAREEGR--NRPQVPNPIKMPEPARIAKPQPQLSQYNRYDQERFNRQKEETEGFKIDTLGTYHG 318
            :|||||||  .:.|..|..:: :|| |...||..:.||||||||| :.|||||||||||:|||||
Zfish   255 VKAREEGRAPEQRQTQNQTQV-DPA-IRNKQPVPAAYNRYDQERF-KGKEETEGFKIDTMGTYHG 316

  Fly   319 MSLKSVTEGSLAQRKAQANNLPGAPGVIAGAAAGRPKELLPAAQARQLPANGPSKRTSRTPIIII 383
            |:|||||||:.| ||||...:...|              .|.:|||. |.|  .|:.||||||||
Zfish   317 MTLKSVTEGASA-RKAQTPAMQPVP--------------RPVSQARP-PPN--QKKGSRTPIIII 363

  Fly   384 PSANTSLITMLNAKDILQELRFMSTSDKKLQGCQRECEVLLQRKRN---------NQTVSYRVID 439
            |:|.|||||||||||:||:|:|:::.:||.||.||:.||||||:::         :.||.|||||
Zfish   364 PAATTSLITMLNAKDLLQDLKFVTSEEKKKQGIQRDNEVLLQRRKDQVQPGGATLSVTVPYRVID 428

  Fly   440 NPTKLSQQEWQRVVAVFVMGPQWQFKGWPW---EGNPVDIFSKICAFHLCFSEMKLDSNVERWSV 501
            .|.||:.|:|.|||||||.||.||||||||   :|:|||||:||.||||.:.|.::|.||::|.|
Zfish   429 QPLKLAPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIRAFHLKYDEARMDPNVQKWDV 493

  Fly   502 TLLRLSQNKRHMDRAVLSKFWETLDKYIAKYKPDLRY 538
            |:|.||.:|||:||.|..:||||||:|:.|:|..||:
Zfish   494 TVLELSHHKRHLDRPVFLRFWETLDRYMVKHKSHLRF 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyx	NP_001163564.1	CDC73_N	1..297	CDD:292669	176/302 (58%)
hyx	NP_001163564.1	CDC73_C	376..527	CDD:282965	99/162 (61%)
cdc73	NP_001278325.1	CDC73_N	1..296	CDD:292669	176/302 (58%)
cdc73	NP_001278325.1	CDC73_C	356..519	CDD:282965	99/162 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590624
Domainoid	1	1.000	314	1.000	Domainoid score	I1259
eggNOG	1	0.900	-	-		E1_COG5157
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11571
Inparanoid	1	1.050	576	1.000	Inparanoid score	I1004
OMA	1	1.010	-	-		QHG56143
OrthoDB	1	1.010	-	-		D384163at33208
OrthoFinder	1	1.000	-	-		FOG0004392
OrthoInspector	1	1.000	-	-		oto41527
orthoMCL	1	0.900	-	-		OOG6_102858
Panther	1	1.100	-	-	LDO	PTHR12466
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R183
SonicParanoid	1	1.000	-	-		X4776
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800