Protein Alignment hyx and Cdc73

DIOPT Version :10

• Sequence 1: NP_649863.1
• Gene: hyx / 41086
• FlyBaseID: FBgn0037657
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001019940.1
• Gene: Cdc73 / 304832
• RGDID: 1311766
• Length: 531
• Species: Rattus norvegicus
• Alignment Length: 555
• Identity: 322/555 - (58%)
• Similarity: 398/555 - (71%)
• Gaps: 41/555 - (7%)

  Fly     1 MADPLSLLRQYNINKKEIVERDSQIIFGEFSWPKSVKTNYLKYGSGKKGAPREYYTLECLLYLLK 65
            |||.||:||||||.|||||.:..::|||||||||:|||||:.:|:||:|.|||||||:.:|:||.
  Rat     1 MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLN 65

  Fly    66 NVMLQHSVYVRQCAAEDIPAVNRPDRKELLAYLNGETPTCASIDKSAPLEI----PTQVKRAAEG 126
            ||.|.|.||||:.|.|:||.|.|||||:||.|||||..|.||||:||||||    .|||||||:
  Rat    66 NVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAAD- 129

  Fly   127 EPSSVEVAAKKARFEETQ-VQKVREQLAARWDVNQKETAVNMDNIKSLSETMSVEKIAAIKAKRL 190
               .|...|||.|.|:.: |:..:|:||||.: ..||..|..:.|:||||.|.||||||||||.:
  Rat   130 ---EVLAEAKKPRIEDEECVRLDKERLAARLE-GHKEGIVQTEQIRSLSEAMLVEKIAAIKAKIM 190

  Fly   191 ANKRTTIKRTDNDEAMGTDLRAILDYDVDSTKDIISRERQWRTRTSILQSTGKIFAKNIFAMLQG 255
            |.||:|||...:|:......|:.:|.:||.|:||:||||.|||||:|||||||.|:|||||:||.
  Rat   191 AKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQS 255

  Fly   256 IKAREEGRNRPQVPNPIKMPEPARIAKPQPQLSQYNRYDQERFNRQKEETEGFKIDTLGTYHGMS 320
            :|||||||...|.|.|...|....:...||..:.||||||||| :.|||||||||||:||||||:
  Rat   256 VKAREEGRAPEQRPAPNAAPVDPTLRTKQPIPAAYNRYDQERF-KGKEETEGFKIDTMGTYHGMT 319

  Fly   321 LKSVTEGSLAQRKAQANNLPGAPGVIAGAAAGRPKELLPAAQARQLPANGPSKRTSRTPIIIIPS 385
            |||||||:.| ||.|.   |.|..|        |:   |.:|||. |.|  .|:.|||||||||:
  Rat   320 LKSVTEGASA-RKTQT---PAAQPV--------PR---PVSQARP-PPN--QKKGSRTPIIIIPA 366

  Fly   386 ANTSLITMLNAKDILQELRFMSTSDKKLQGCQRECEVLLQRKRNNQ---------TVSYRVIDNP 441
            |.|||||||||||:||:|:|:.:.:||.||||||.|.|:||:::..         ||.|||:|.|
  Rat   367 ATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQP 431

  Fly   442 TKLSQQEWQRVVAVFVMGPQWQFKGWPW---EGNPVDIFSKICAFHLCFSEMKLDSNVERWSVTL 503
            .||..|:|.|||||||.||.||||||||   :|:|||||:||.||||.:.|::||.||::|.||:
  Rat   432 LKLMPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTV 496

  Fly   504 LRLSQNKRHMDRAVLSKFWETLDKYIAKYKPDLRY 538
            |.||.:|||:||.|..:||||||:|:.|:|..||:
  Rat   497 LELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hyx	NP_649863.1	CDC73_N	1..297	CDD:464994	175/300 (58%)
		CDC73_C	376..527	CDD:461570	99/162 (61%)
Cdc73	NP_001019940.1	CDC73_N	1..297	CDD:464994	175/300 (58%)
		Nuclear localization signal. /evidence=ECO:0000250	125..139		8/17 (47%)
		Interaction with POLR2A and PAF1. /evidence=ECO:0000250	200..531		197/349 (56%)
		Interaction with CTNNB1. /evidence=ECO:0000250	200..250		27/49 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..292		11/31 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..358		17/50 (34%)
		CDC73_C	357..520	CDD:461570	99/162 (61%)