Protein Alignment hyx and Cdc73

DIOPT Version :9

• Sequence 1: NP_001163564.1
• Gene: hyx / 41086
• FlyBaseID: FBgn0037657
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_666103.1
• Gene: Cdc73 / 214498
• MGIID: 2384876
• Length: 531
• Species: Mus musculus
• Alignment Length: 555
• Identity: 323/555 - (58%)
• Similarity: 399/555 - (71%)
• Gaps: 41/555 - (7%)

  Fly     1 MADPLSLLRQYNINKKEIVERDSQIIFGEFSWPKSVKTNYLKYGSGKKGAPREYYTLECLLYLLK 65
            |||.||:||||||.|||||.:..::|||||||||:|||||:.:|:||:|.|||||||:.:|:||.
Mouse     1 MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLN 65

  Fly    66 NVMLQHSVYVRQCAAEDIPAVNRPDRKELLAYLNGETPTCASIDKSAPLEI----PTQVKRAAEG 126
            ||.|.|.||||:.|.|:||.|.|||||:||.|||||..|.||||:||||||    .|||||||:
Mouse    66 NVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAAD- 129

  Fly   127 EPSSVEVAAKKARFEETQ-VQKVREQLAARWDVNQKETAVNMDNIKSLSETMSVEKIAAIKAKRL 190
               .|...|||.|.|:.: |:..:|:||||.: ..||..|..:.|:||||.||||||||||||.:
Mouse   130 ---EVLAEAKKPRIEDEECVRLDKERLAARLE-GHKEGIVQTEQIRSLSEAMSVEKIAAIKAKIM 190

  Fly   191 ANKRTTIKRTDNDEAMGTDLRAILDYDVDSTKDIISRERQWRTRTSILQSTGKIFAKNIFAMLQG 255
            |.||:|||...:|:......|:.:|.:||.|:||:||||.|||||:|||||||.|:|||||:||.
Mouse   191 AKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQS 255

  Fly   256 IKAREEGRNRPQVPNPIKMPEPARIAKPQPQLSQYNRYDQERFNRQKEETEGFKIDTLGTYHGMS 320
            :|||||||...|.|.|...|....:...||..:.||||||||| :.|||||||||||:||||||:
Mouse   256 VKAREEGRAPEQRPAPNAAPVDPTLRTKQPIPAAYNRYDQERF-KGKEETEGFKIDTMGTYHGMT 319

  Fly   321 LKSVTEGSLAQRKAQANNLPGAPGVIAGAAAGRPKELLPAAQARQLPANGPSKRTSRTPIIIIPS 385
            |||||||:.| ||.|.   |.|..|        |:   |.:|||. |.|  .|:.|||||||||:
Mouse   320 LKSVTEGASA-RKTQT---PAAQPV--------PR---PVSQARP-PPN--QKKGSRTPIIIIPA 366

  Fly   386 ANTSLITMLNAKDILQELRFMSTSDKKLQGCQRECEVLLQRKRNNQ---------TVSYRVIDNP 441
            |.|||||||||||:||:|:|:.:.:||.||||||.|.|:||:::..         ||.|||:|.|
Mouse   367 ATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQP 431

  Fly   442 TKLSQQEWQRVVAVFVMGPQWQFKGWPW---EGNPVDIFSKICAFHLCFSEMKLDSNVERWSVTL 503
            .||..|:|.|||||||.||.||||||||   :|:|||||:||.||||.:.|::||.||::|.||:
Mouse   432 LKLMPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTV 496

  Fly   504 LRLSQNKRHMDRAVLSKFWETLDKYIAKYKPDLRY 538
            |.||.:|||:||.|..:||||||:|:.|:|..||:
Mouse   497 LELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hyx	NP_001163564.1	CDC73_N	1..297	CDD:292669	176/300 (59%)
		CDC73_C	376..527	CDD:282965	99/162 (61%)
Cdc73	NP_666103.1	CDC73_N	1..297	CDD:406455	176/300 (59%)
		Nuclear localization signal. /evidence=ECO:0000250	125..139		8/17 (47%)
		Interaction with POLR2A and PAF1. /evidence=ECO:0000250	200..531		197/349 (56%)
		Interaction with CTNNB1. /evidence=ECO:0000250	200..250		27/49 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..292		11/31 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..358		17/50 (34%)
		CDC73_C	357..520	CDD:398719	99/162 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845920
Domainoid	1	1.000	323	1.000	Domainoid score	I1208
eggNOG	1	0.900	-	-		E1_COG5157
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11571
Inparanoid	1	1.050	584	1.000	Inparanoid score	I1000
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56143
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004392
OrthoInspector	1	1.000	-	-		oto93790
orthoMCL	1	0.900	-	-		OOG6_102858
Panther	1	1.100	-	-	LDO	PTHR12466
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R183
SonicParanoid	1	1.000	-	-		X4776
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790