DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neur and NEURL1

DIOPT Version :9

Sequence 1:	NP_476652.1	Gene:	neur / 41085	FlyBaseID:	FBgn0002932	Length:	754	Species:	Drosophila melanogaster
Sequence 2:	XP_011538633.1	Gene:	NEURL1 / 9148	HGNCID:	7761	Length:	612	Species:	Homo sapiens

Alignment Length:	690	Identity:	186/690 - (26%)
Similarity:	282/690 - (40%)	Gaps:	202/690 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 CPG---PNNLP--PLQFH-SVHGDNIRISRDGTLARRFESFCRAITFSARPVRINERICVKFAEI 156
            ||.   ...||  ||.|| ...|..|.:.......:|..|||.|||||.|||.|.|::.:|..:.
Human    87 CPAVLPSGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKK 151

  Fly   157 SNNWNGGIRFGFTSNDPVTLE-GTLPKYACPDLTNRPGFWAKALHEQYCEKDNILYYYVNGAGDV 220
            ...|:|.:|.||||.||..:. .:|||||||||.::.|||||||.|::..:.||:.::|:..|.|
Human   152 QCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRV 216

  Fly   221 IYGINNEEKGVILTGIDTRSLLWTVIDIYGNCTGIEFLDS----------RIYMYQQQPA----- 270
            .:.||:....:..:|:.|...||.::|:||...|::.|||          |.:...::|:
Human   217 FHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRREA 281

  Fly   271 -------AIPMATVPAQQQQMPQPAANA---SSALNSHHPHQQSRRSLPGHTAAIEHDLERHVMP 325
                   ::....||........|||..   .::|||.|     .|:||   |.::.||..|.:.
Human   282 DDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQH-----SRALP---AQLDGDLRFHALR 338

  Fly   326 SLQSLHLAGNGGSVASVEQAAIAHDLANGLPPLRYNANGRLIPVPFHNTKGRNVRLSQDRFVASR 390
            :                                                 |.:||:..::.||..
Human   339 A-------------------------------------------------GAHVRILDEQTVARV 354

  Fly   391 TESDFCQGYVFTARPIRIGEKLIVQVLKTEQMYVGALALGLTSCNPAMLQPNDLPNDSDFLLDRP 455
            ......:..|||:||:|:.|.:.|:|.::.....|||:.|:|:|:|..|:|.|||...:.|:||.
Human   355 EHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSPEALVDRK 419

  Fly   456 EYWVVSKDIAAAPQRGDEIAFFVAPNGEVSISKNNGPAVVVMHVDQSLQLWAFLDVYGSTQSLRM 520
            |:|.|.: :......||.:...|..:||:.:|.|...|.:.:.||.|..||....::|:...:|:
Human   420 EFWAVCR-VPGPLHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLFGLHGTITQIRI 483

  Fly   521 FRQQLPNMVAYPSQPQVNVNASSSSACNAASTSRMLPMTESMSSLNAGATAKLLHHPSQLSVAQS 585
            ....:......||.|           |:.|||    |.:                 ||.|
Human   484 LGSTILAERGIPSLP-----------CSPAST----PTS-----------------PSAL----- 511

  Fly   586 TSTLASAGGVNGSRMISMPSNGDILQIQPNGGGTVLVVNLPPASSSHDINGQLAARPTATVTSSG 650
                       |||:                                                |.
Human   512 -----------GSRL------------------------------------------------SD 517

  Fly   651 VLAGACSSGTLISTTSSQYIEQPIA---NSTNNAANKWKDSLSDQQSTDSSAECTICYENPIDSV 712
            .|...||||.|.|:........|::   :.......:|.|            |||||||:.:|:|
Human   518 PLLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSD------------ECTICYEHAVDTV 570

  Fly   713 LYMCGHMCMCYDCAIEQWRGVGGGQCPLCRAVIRDVIRTY 752
            :|.|||||:||.|.:...:.: ...||:||..|:|:|:||
Human   571 IYTCGHMCLCYACGLRLKKAL-HACCPICRRPIKDIIKTY 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neur	NP_476652.1	NEUZ	106..225	CDD:128856	52/120 (43%)
		SPRY	108..255	CDD:295394	59/148 (40%)
		Neuralized	109..173	CDD:284568	26/64 (41%)
		NEUZ	367..489	CDD:128856	38/121 (31%)
		SPRY	371..519	CDD:295394	46/147 (31%)
		Neuralized	371..436	CDD:284568	20/64 (31%)
		zf-C3HC4_3	700..748	CDD:290631	23/47 (49%)
NEURL1	XP_011538633.1	NEUZ	99..221	CDD:128856	52/121 (43%)
		SPRY	103..251	CDD:295394	59/147 (40%)
		Neuralized	103..168	CDD:284568	26/64 (41%)
		NEUZ	330..452	CDD:128856	41/171 (24%)
		SPRY	333..484	CDD:295394	48/200 (24%)
		Neuralized	334..400	CDD:284568	21/114 (18%)
		zf-C3HC4_3	556..605	CDD:290631	24/61 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5361
eggNOG	1	0.900	-	-		E1_KOG4172
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3405
Isobase	1	0.950	-	0	Normalized mean entropy	S6216
OMA	1	1.010	-	-		QHG45583
OrthoDB	1	1.010	-	-		D1384219at2759
OrthoFinder	1	1.000	-	-		FOG0001576
OrthoInspector	1	1.000	-	-		otm41163
orthoMCL	1	0.900	-	-		OOG6_105976
Panther	1	1.100	-	-	O	PTHR12429
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4099
SonicParanoid	1	1.000	-	-		X1904
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820