Protein Alignment neur and NEURL4

DIOPT Version :10

• Sequence 1: NP_476652.1
• Gene: neur / 41085
• FlyBaseID: FBgn0002932
• Length: 754
• Species: Drosophila melanogaster
• Sequence 2: NP_115818.2
• Gene: NEURL4 / 84461
• HGNCID: 34410
• Length: 1562
• Species: Homo sapiens
• Alignment Length: 761
• Identity: 157/761 - (20%)
• Similarity: 258/761 - (33%)
• Gaps: 256/761 - (33%)

  Fly    94 SPSSCPGPNNLPPLQFHSVHGDNIRISRDGTLARRFESFCR-----AITFSARPVRINERICVKF 153
            ||||..|.::   |:||.:||.|..|:..|..|.|..  ||     ||..|.|.:|..|...:..
Human   707 SPSSGAGGSD---LRFHQLHGSNAVITNGGRTALRHN--CRSEFNDAIVISNRALRDGELFEIVI 766

  Fly   154 AEISNNWNGGIRFGFTSNDPVTLE----------------GTLPKYACPDLTNRPGFWAKALHEQ 202
            .::.:.|:|.|..|.|:..|..||                ||........:.|..|
Human   767 QKMVDRWSGSIEAGVTAIRPEDLEFPNTMTDIDYDTWMLSGTAIMQDGNTMRNNYG--------- 822

  Fly   203 YCEKDNILYYYVNGA---------GDVIYGINNEEKGVILTGIDTRSLLWTVIDIYGNCTGIEFL 258
             |:.|.:    ..||         ||:.|.||.:::|...:|:.....::.|:|:||.|..:
Human   823 -CDLDAL----GTGARIGMMRTAKGDLHYFINGQDQGAACSGLPPGKEVYAVVDLYGQCVQV--- 879

  Fly   259 DSRIYMYQQQPAAIPMATVPAQQQQMPQPAANASSALNSHHPHQQSRRSLPGHTAAIEHDLERHV 323
                        :|..||.|     |....|.:::|         :.:|.|.|:..
Human   880 ------------SITNATGP-----MDNSLATSNTA---------TEKSFPLHSPV--------- 909

  Fly   324 MPSLQSLHLAGNGGSVASVEQAAIAHDLANGLPPLRYNANGRLIPVPFHNTKGRNVRLSQDRFVA 388
                                 |.:||                    .||:|.|:||.|.:|...|
Human   910 ---------------------AGVAH--------------------RFHSTCGKNVTLEEDGTRA 933

  Fly   389 SRTESDFCQGYVFTARPIRIGEKLIVQVLKTEQMYVGALALGLTSCNPAMLQPN------DLPND 447
            .|. :.:..|.||:.:.:|..|...|:|.:.::.:.|:|.||||:..|..:.|.      .||..
Human   934 VRA-AGYAHGLVFSTKELRAEEVFEVKVEELDEKWAGSLRLGLTTLAPGEMGPGAGGGGPGLPPS 997

  Fly   448 SDFLLDRPEYWVVSKDIAAAPQ----------------------RGDEIAFFVAPNGEVSISKNN 490
            ...|..:..:.|.|.::....|                      ||.:....:..:||     :.
Human   998 LPELRTKTTWMVSSCEVRRDGQLQRMNYGRNLERLGVGSRVGVRRGADDTMHILVDGE-----DM 1057

  Fly   491 GPAVVVMHVDQSLQLWAFLDVYGSTQ------SLRMFRQQ------------------------- 524
            |||...:    :..:||.||:||..:      |.|:...:
Human  1058 GPAATGI----AKNVWAVLDLYGPVRGVSIVSSTRLEESEGTQPPSPSSDTGSEGEEDDEGEEHG 1118

  Fly   525 ---------LPNMVAYPSQPQVNVNASSS--SACNAASTSRML-----PMTESM----------- 562
                     :|..:.:......|:..|:.  :|...||.::.:     |:...:
Human  1119 LGGQNEVGIIPTTLEFLENHGKNILLSNGNRTATRVASYNQGIVVINQPLVPQLLVQVRIDFLNR 1183

  Fly   563 ---SSLNAG---ATAKLLHHPSQLSVAQSTSTLASAGGV--NGSRMISMPSNGDILQIQPNGGGT 619
               |||..|   ...:.|:.|:.....:..:.|....||  ||.::..  ..|..|...|.  ||
Human  1184 QWTSSLVLGVITCAPERLNFPASACALKRAAWLLRGRGVFHNGLKICE--KFGPNLDTCPE--GT 1244

  Fly   620 VLVVNLPPASSSH-DING--QLAARPTATVTSSGV--LAGACSSGTLISTTSSQYIEQPIANSTN 679
            :|.:.|..:...| .:||  |..|.|........:  |.|.|...|:::       .:|.|.|..
Human  1245 ILGLRLDSSGGLHLHVNGVDQGVAVPDVPQPCHALVDLYGQCEQVTIVN-------PEPGAASGK 1302

  Fly   680 NAANKWKDSLSDQQSTD--SSAECTICY-ENPIDSVLYMCGHMCMC 722
            :|..:     .|.:..|  ...:.::|: ..|..|.|..|.:..:|
Human  1303 SAGTQ-----GDMEKADMVDGIKESVCWGPPPAASPLKSCEYHALC 1343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neur	NP_476652.1	Neuralized	109..259	CDD:462112	45/179 (25%)
		Neuralized	371..520	CDD:462112	45/182 (25%)
		mRING-HC-C3HC5_NEU1	698..752	CDD:438309	6/26 (23%)
NEURL4	NP_115818.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48
		SPRY_NHR_like	43..205	CDD:293945
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..236
		SPRY_NHR_like	320..482	CDD:293945
		SPRY_NHR_like	523..684	CDD:293945
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	691..716		5/8 (63%)
		SPRY_NHR_like	718..882	CDD:293945	45/194 (23%)
		SPRY_NHR_like	915..1084	CDD:293945	44/178 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1086..1123		2/36 (6%)
		SPRY_NHR_like	1133..1292	CDD:293945	34/162 (21%)