DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neur and neurl1ab

DIOPT Version :9

Sequence 1:	NP_476652.1	Gene:	neur / 41085	FlyBaseID:	FBgn0002932	Length:	754	Species:	Drosophila melanogaster
Sequence 2:	NP_001070176.2	Gene:	neurl1ab / 767739	ZFINID:	ZDB-GENE-060929-1210	Length:	521	Species:	Danio rerio

Alignment Length:	697	Identity:	194/697 - (27%)
Similarity:	279/697 - (40%)	Gaps:	214/697 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 GLVRRSPSS-------------CPGPNNLP---PLQFH-SVHGDNIRISRDGTLARRFESFCRAI 136
            |.|.||.|.             ||   .||   ||.|| :..|..|.:.:.....||..|||.||
Zfish     3 GQVTRSTSDTVTLHCHPLKANMCP---QLPAPLPLCFHANTKGSQIVMDKTQRSVRRIASFCNAI 64

  Fly   137 TFSARPVRINERICVKFAEISNNWNGGIRFGFTSNDPVTLEGT-LPKYACPDLTNRPGFWAKALH 200
            ||::|||.:.|::.:|..:....|:|.:|.||:..||..:... ||::|||||.:..|||.:||.
Zfish    65 TFTSRPVGVYEQVRLKITKTQGCWSGALRVGFSIVDPSNISSAWLPRFACPDLVSEQGFWGRALP 129

  Fly   201 EQYCEKDNILYYYVNGAGDVIYGINNEEKGVILTGIDTRSLLWTVIDIYGNCTGIEFLDSRIYMY 265
            |::||:..||.::::..|.|.|.:|........:|:.....:|.:|||||...|:..||.::
Zfish   130 EEHCEEGTILSFWLDNIGRVFYRVNGGSPIFFFSGVPAGEPVWGIIDIYGLTRGVHLLDCKM--- 191

  Fly   266 QQQPAAIPMATVPAQQQQMPQPAA--------NASSALNSHHPHQQSRRSLPGHTAAIEHDLERH 322
                       :||:..   .||.        |.||..:                   |.||:..
Zfish   192 -----------LPAEYL---SPAVTHEGMDDWNLSSGCS-------------------EFDLQED 223

  Fly   323 VMPSLQSLHLAGNGGSVASVEQAAIAHDLANGLPPLRYNANGRLIPVPFHNTKGRNVRLSQDRFV 387
             :||..|...|.|         ..::|.|::.|              .||:..|..:||..:...
Zfish   224 -LPSFSSSPNALN---------LLLSHQLSDDL--------------HFHSVHGSALRLLTEHIA 264

  Fly   388 A---SRTESDFCQGYVFTARPIRIGEKLIVQV-LKTEQMYVGALALGLTSCNPAMLQPNDLPNDS 448
            .   :|.|:  | ..|||.||:|.||.:.::| |::.    |.|:.|.||||||.:....||.|.
Zfish   265 VRYYNRREA--C-ALVFTHRPLRCGECVFLKVSLRSS----GFLSYGFTSCNPAHVNSKHLPVDP 322

  Fly   449 DFLLDRPEYWVVSKDIAAAPQRGDEIAFFVAPNGEVSISKNNGPAVVVMHVDQSLQLWAFLDVYG 513
            |.||||.|:|..| .:.:|...||.|.|.....|||.:|.|.|.|...|.||.|..||....:..
Zfish   323 DELLDRKEFWAFS-SMTSALVGGDIIGFRATAEGEVLVSHNGGRARREMCVDNSAPLWMIFHLQT 386

  Fly   514 STQSLRMFRQQLPNMVAYPSQPQVNVNASS---SSACNAASTSRMLPMTESMSSLNAGATAKLLH 575
            ..:                   |:::..:|   |.:|           :|:..|:.:.|
Zfish   387 HIK-------------------QISILGTSRGYSPSC-----------SETQRSIFSDA------ 415

  Fly   576 HPSQLSVAQSTSTLASAGGVNGSRMISMPSNGDILQIQPNGGGTVLVVNLPPASSSHDINGQLAA 640
              |.||..|..||..        |..:..|       ||
Zfish   416 --SHLSANQIHSTTI--------RRCTDSS-------QP-------------------------- 437

  Fly   641 RPTATVTSSGVLAGACSSGTLISTTSSQYIEQPIANSTNNAANKWKDSLSDQQSTDSSAECTICY 705
            ||.:..:|.|...|:.||            |.|...:.                  :..||.||.
Zfish   438 RPHSLSSSLGTAFGSLSS------------ESPSCCAL------------------TGEECLICC 472

  Fly   706 ENPIDSVLYMCGHMCMCYDCAIEQWRGVGGGQCPLCRAVIRDVIRTY 752
            :.|:|||||.|||||:|.||.::... .....||:||:.|||:|:.|
Zfish   473 DRPVDSVLYACGHMCVCSDCGVKLTE-TSNPSCPVCRSPIRDIIKIY 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neur	NP_476652.1	NEUZ	106..225	CDD:128856	47/120 (39%)
		SPRY	108..255	CDD:295394	53/148 (36%)
		Neuralized	109..173	CDD:284568	23/64 (36%)
		NEUZ	367..489	CDD:128856	47/125 (38%)
		SPRY	371..519	CDD:295394	56/151 (37%)
		Neuralized	371..436	CDD:284568	24/68 (35%)
		zf-C3HC4_3	700..748	CDD:290631	24/47 (51%)
neurl1ab	NP_001070176.2	NEUZ	33..154	CDD:128856	47/120 (39%)
		SPRY	36..187	CDD:295394	54/150 (36%)
		Neuralized	36..101	CDD:284568	23/64 (36%)
		NEUZ	244..362	CDD:128856	48/139 (35%)
		SPRY	247..394	CDD:295394	57/173 (33%)
		Neuralized	248..310	CDD:284568	24/68 (35%)
		zf-C3HC4_3	466..514	CDD:290631	24/48 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5205
eggNOG	1	0.900	-	-		E1_KOG4172
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3234
OMA	1	1.010	-	-		QHG45583
OrthoDB	1	1.010	-	-		D562994at33208
OrthoFinder	1	1.000	-	-		FOG0001576
OrthoInspector	1	1.000	-	-		otm25323
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12429
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4099
SonicParanoid	1	1.000	-	-		X1904
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.970