DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neur and neurl1aa

DIOPT Version :9

Sequence 1:	NP_476652.1	Gene:	neur / 41085	FlyBaseID:	FBgn0002932	Length:	754	Species:	Drosophila melanogaster
Sequence 2:	XP_021330967.1	Gene:	neurl1aa / 561943	ZFINID:	ZDB-GENE-090311-3	Length:	572	Species:	Danio rerio

Alignment Length:	743	Identity:	201/743 - (27%)
Similarity:	313/743 - (42%)	Gaps:	200/743 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 HQNQQHLQHLQQMQQLHNAMPTPAQQAAQVLAMESNELLMSTKDKL-----SSKKKMHLLKKIKK 86
            |:.||:     :.|:|.|                      |.||.|     |:..:.|
Zfish    10 HRGQQN-----RFQRLPN----------------------SHKDSLGGPFPSTAHRCH------- 40

  Fly    87 RFGLVRRSPSSC-P----GPNNLPPLQFH-SVHGDNIRISRDGTLARRFESFCRAITFSARPVRI 145
                  ..|..| |    |...:.||.|| :..|..|.:.......:|..|||.|||||.||:.:
Zfish    41 ------HKPKRCLPLHQCGGVLMSPLLFHPNAKGSQIVMDLAQRSVKRQASFCNAITFSNRPIAL 99

  Fly   146 NERICVKFAEISNNWNGGIRFGFTSNDPVTLE-GTLPKYACPDLTNRPGFWAKALHEQYCEKDNI 209
            .|::.:|..:....|:|.:|.||||.||..:. .:|||||||||.::.|||||||.|::..:.|:
Zfish   100 YEQVRLKITKKQCCWSGALRLGFTSKDPSRINPDSLPKYACPDLVSQSGFWAKALPEEFANEGNL 164

  Fly   210 LYYYVNGAGDVIYGINNEEKGVILTGIDTRSLLWTVIDIYGNCTGIEFLDSRIYMYQQQPAAI-P 273
            :.::|:..|.|.|.||:....:..:|:.|...||.:||:||...|::.|:|.:.    .|..: |
Zfish   165 ISFWVDKKGRVFYRINDSSPMLFFSGVRTTEPLWALIDVYGLTRGVQLLESEVV----PPDLLRP 225

  Fly   274 MATVPAQQQQMPQPAANAS----SALNSHHPHQQSRRSLPGHTAAIEHDLERHVMPSLQSLHLAG 334
            .:....:.....:..|:.|    |..:.:.|...||..||  .|.:...:.::.|.|.||
Zfish   226 RSFTTVRGSTSLRREADTSRLSVSLCDLNLPQDDSRLRLP--PAPVTCPIPQNSMNSQQS----- 283

  Fly   335 NGGSVASVEQAAIAHDLANGLPPLRYNANGRLIPVPFHNTKGRNVRLSQDRFVASRTESDFCQGY 399
                      :.:.|.|.              ..:.||..:|.::::..::.||....:...:..
Zfish   284 ----------SLLPHTLE--------------CDIRFHQLRGAHIKILNEQTVARSEHNREERTL 324

  Fly   400 VFTARPIRIGEKLIVQVLKTEQMYVGALALGLTSCNPAMLQPNDLPNDSDFLLDRPEYWVVSKDI 464
            |||.||:||||.:.::|:|:.....|:|:.|:|||:||:|:|:|||.:.:.|:||.|:|.|.: :
Zfish   325 VFTDRPLRIGETIFIKVIKSSPARFGSLSYGVTSCDPAVLRPSDLPYNPEALVDRKEFWAVCR-V 388

  Fly   465 AAAPQRGDEIAFFVAPNGEVSISKNNGPAVVVMHVDQSLQLWAFLDVYGSTQSLRMFRQQLPNMV 529
            ..|.|..|.:.|.|...|||.:|.|.....:.:.||.|..||.|..::|:...||:.........
Zfish   389 PTALQSADILGFLVTQEGEVILSHNGTNVGMQVCVDNSRPLWMFFGLHGAVTQLRILGSTFLGDA 453

  Fly   530 AYPSQPQVNVNASSSSACNAASTSRMLPMTESMSSLNAGATAKLLHHPSQLSVAQSTSTLASAGG 594
            ..||.|. :.:||.|..|
Zfish   454 RDPSSPG-SPSASPSGLC----------------------------------------------- 470

  Fly   595 VNGSRMISMPSNGDILQIQPNGGGTVLVVNLPPASSSHDINGQLAARPTATVTSSGVLAGACSSG 659
                                  ||:       |..|.|:               .|..|..|||.
Zfish   471 ----------------------GGS-------PEPSLHE---------------RGCSAAFCSST 491

  Fly   660 TLISTTSSQYIEQPIANSTNNAANKWKDSLSDQQSTDSSAECTICYENPIDSVLYMCGHMCMCYD 724
            .  .||.:..|..|.:.:..:|:..|.|            ||:|||||.:|:|:|.|||||:||.
Zfish   492 E--GTTPNSPINLPKSPTFPSASGSWLD------------ECSICYENTVDTVIYTCGHMCLCYT 542

  Fly   725 CAIEQWRGVGGGQCPLCRAVIRDVIRTY 752
            |.: :.:.:....||:||..|:|:|:||
Zfish   543 CGL-RLKKMANASCPICRRAIKDIIKTY 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neur	NP_476652.1	NEUZ	106..225	CDD:128856	50/120 (42%)
		SPRY	108..255	CDD:295394	58/148 (39%)
		Neuralized	109..173	CDD:284568	24/64 (38%)
		NEUZ	367..489	CDD:128856	44/121 (36%)
		SPRY	371..519	CDD:295394	52/147 (35%)
		Neuralized	371..436	CDD:284568	22/64 (34%)
		zf-C3HC4_3	700..748	CDD:290631	23/47 (49%)
neurl1aa	XP_021330967.1	NEUZ	59..180	CDD:128856	50/120 (42%)
		Neuralized	296..446	CDD:311244	54/150 (36%)
		mRING-HC-C3HC5_NEU1A	517..560	CDD:319699	22/55 (40%)
		modified RING-HC finger (C3HC5-type)	519..558	CDD:319699	19/39 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5205
eggNOG	1	0.900	-	-		E1_KOG4172
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3234
OMA	1	1.010	-	-		QHG45583
OrthoDB	1	1.010	-	-		D1384219at2759
OrthoFinder	1	1.000	-	-		FOG0001576
OrthoInspector	1	1.000	-	-		otm25323
orthoMCL	1	0.900	-	-		OOG6_105976
Panther	1	1.100	-	-	O	PTHR12429
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4099
SonicParanoid	1	1.000	-	-		X1904
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870