DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment neur and Neurl2

DIOPT Version :9

Sequence 1:NP_476652.1 Gene:neur / 41085 FlyBaseID:FBgn0002932 Length:754 Species:Drosophila melanogaster
Sequence 2:NP_001076443.1 Gene:Neurl2 / 415115 MGIID:3043305 Length:285 Species:Mus musculus


Alignment Length:241 Identity:55/241 - (22%)
Similarity:86/241 - (35%) Gaps:87/241 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 RSPSSCPGPNNLPPLQFHSVHGDNIRISRDGTLARRFESFCRAITFSARPVRINERICVKFAEIS 157
            |||:. |.|   ||.:||.|||.|||:...||.|.|.|||...:.||..|:...:...|:..|..
Mouse    14 RSPAR-PEP---PPTRFHQVHGANIRMDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEIEEKE 74

  Fly   158 NNWNGGIRFGFTSNDPVTLEGTLPKYACPDLT--------------------------------- 189
            ..|.|.:|.|.|:.||.:| ..:|:::.|||.                                 
Mouse    75 LGWCGHLRLGLTALDPASL-AAVPEFSLPDLVSLGHSWVFAITRHHNRVPREGQPEAEAAVPSGP 138

  Fly   190 ------------------------NRPGFWAKALHEQY------------------CEKDNILYY 212
                                    :|||.::..|.:.|                  |.::     
Mouse   139 QALLVEPYLRIEQFRIPRDRLVGRSRPGLYSHLLDQLYEQNVLPPTARRSRLGVLFCPRE----- 198

  Fly   213 YVNGAGDVIYGINNEEKGVILTGIDTRSLLWTVIDIYGNCTGIEFL 258
              :|..|:...||.|:.|....|:.....|:.|:|::.:...:..:
Mouse   199 --DGTADMHIIINGEDMGPSARGLPAAQPLYAVVDVFASTKSVRLV 242

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
neurNP_476652.1 NEUZ 106..225 CDD:128856 41/193 (21%)
SPRY 108..255 CDD:295394 48/221 (22%)
Neuralized 109..173 CDD:284568 25/63 (40%)
NEUZ 367..489 CDD:128856
SPRY 371..519 CDD:295394
Neuralized 371..436 CDD:284568
zf-C3HC4_3 700..748 CDD:290631
Neurl2NP_001076443.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28 8/17 (47%)
SPRY_NHR_like 25..242 CDD:293945 48/224 (21%)
SOCS_box 249..285 CDD:198037
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4625
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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