DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neur and Neurl4

DIOPT Version :9

Sequence 1:	NP_476652.1	Gene:	neur / 41085	FlyBaseID:	FBgn0002932	Length:	754	Species:	Drosophila melanogaster
Sequence 2:	NP_001013432.1	Gene:	Neurl4 / 216860	MGIID:	1921092	Length:	1563	Species:	Mus musculus

Alignment Length:	782	Identity:	168/782 - (21%)
Similarity:	274/782 - (35%)	Gaps:	198/782 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 PSSCPGP-------NNLPPL----------QFHSVHGDNIRISRDGTLARR---FESFCRAITFS 139
            |...|||       ::.|.|          :.|...|..:.:|..|..|||   .:.|...:..|
Mouse    15 PGPGPGPGGGGGPGSSGPGLGSGGGLGGGGELHPRTGRLVSLSACGRTARRQQPGQEFNHGLVLS 79

  Fly   140 ARPVRINERICVKFAEISNNWNGGIRFGFTSNDPVTLEGTLPKYACPDLTN-RPGFW-------- 195
            ..|:|......|:.....|:|:|.|..|.|:.||..|:  .|..|    |. :.|.|
Mouse    80 REPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLD--FPSSA----TGLKGGSWVVSGCSVL 138

  Fly   196 --AKALHEQYCEKDNILYYYVNG---------AGDVIYGINNEEKGVILTGIDTRSLLWTVIDIY 249
              .:::.|:|.:.   |...|.|         .|::...:|..:.||..||:..|  :|.|:|:|
Mouse   139 RDGRSVLEEYGQD---LDQLVEGDRVGVERTATGELRLWVNGRDCGVAATGLPAR--VWAVVDLY 198

  Fly   250 GNCTGIEFLDSRIYMYQQQPA---AIPMATVPAQQQQMPQPAANASSALNSHHPHQ----QSR-- 305
            |.||.|..|.|       :|.   ..|:.|.|.:....|:.:|......:......    |:|
Mouse   199 GKCTQITVLPS-------EPGFSPPTPVPTPPLEPLAPPEDSALLEQGTSVDEAFMVSPAQARPE 256

  Fly   306 ---RSLPGHTAAIEHDLERHVMPSLQSLHLAGNGGSV-ASVEQAAIAHDLANGLP---PLRYNAN 363
               .||..|......:|...|..::.|   |.|||.: .|:........||:..|   |: ..:|
Mouse   257 TFPNSLDSHNDFASMELSEVVSNAILS---AYNGGLLNVSLSSPPAGDGLASSGPATSPI-LTSN 317

  Fly   364 GRLIPVPFHNTKGRNVRLSQDRFVASRTE--SDFCQGYVFTARPIRIGEKLIVQVLKTEQMYVGA 426
            ..|:   ||...|..::||.:...|.|..  .:|..|.|.|.||:|..|...:::.|....:.|:
Mouse   318 DALL---FHEKCGTLIKLSNNNKTAERRRPLDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGS 379

  Fly   427 LALGLTSCNPAMLQ-PNDLPN-DSDFLL------------DRPEYWVVSKDIAAAPQRGDEIAFF 477
            :.:|:|:.||..|: |..:.| .|..::            .|.||...|.|   ..|.||.|...
Mouse   380 IEIGVTTHNPNSLEYPATMTNLQSGTIMMSGCGILTNGKGTRREYCEFSLD---ELQEGDHIGLT 441

  Fly   478 VAPNGEVSISKNNGPAVVVMHVDQSLQ-------LWAFLDVYG----------STQSLRM----- 520
            ...|..:....|.        :||.:.       ::..:|:||          :..|.|:
Mouse   442 RKSNSALHFFING--------IDQGVATPLTPPVVYGVVDLYGMAVKVTIVHNNNHSDRLRRNNA 498

  Fly   521 ----------FRQQLPNMVAYPSQPQVNVNASSSSACNAASTSRMLP------------------ 557
                      .|:..|...|.|.:...:.|....:|......:.:.|
Mouse   499 ILRALSPEGALRRAAPAAQAEPERLLFHPNCGQKAAITHEGRTALRPHATDDFNHGVVLSSRALR 563

  Fly   558 -----------MTESMS-SLNAGATAKLLHHPSQLSVAQSTSTLAS------AGGV--NGSRMI- 601
                       |.:..: |:..|.|.   |:|:.|.:..:.:.|.|      ..||  ||:.::
Mouse   564 DGEVFQVRIDKMVDKWAGSIEIGVTT---HNPAYLQLPSTMTNLRSGTWMMTGNGVMHNGTTILD 625

  Fly   602 SMPSNGDILQIQPNGGGTVLVVNLPPASSSHDINGQLAARPTATVTSSGVLA-----GACSSGTL 661
            ....|.|.|:    .|.||.||.....:....:|| :...|.|.....||.|     |..:..|:
Mouse   626 EYGHNLDRLK----AGDTVGVVRREDGTLHFFVNG-MTQGPAAWNVPPGVYAVVDLYGQAAQATI 685

  Fly   662 ISTTSSQYIEQPIANSTNNAANKWKDSLSDQQSTDSSAECTICYENPIDSVLYMCGHMCMCYDCA 726
            :.......:.:|:....|..      |.|...|....::......:..::|:...|...:.::|.
Mouse   686 VDDVEVPPVSEPLPEGNNQM------SPSSPSSAAGGSDLRFHQLHGSNAVITNGGRTALRHNCR 744

  Fly   727 IE 728
            .|
Mouse   745 SE 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neur	NP_476652.1	NEUZ	106..225	CDD:128856	33/151 (22%)
		SPRY	108..255	CDD:295394	45/169 (27%)
		Neuralized	109..173	CDD:284568	18/66 (27%)
		NEUZ	367..489	CDD:128856	35/137 (26%)
		SPRY	371..519	CDD:295394	42/180 (23%)
		Neuralized	371..436	CDD:284568	19/66 (29%)
		zf-C3HC4_3	700..748	CDD:290631	4/29 (14%)
Neurl4	NP_001013432.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		7/33 (21%)
		SPRY_NHR_like	45..207	CDD:293945	46/172 (27%)
		NEUZ	47..165	CDD:128856	31/126 (25%)
		NEUZ	318..439	CDD:128856	34/126 (27%)
		SPRY_NHR_like	322..484	CDD:293945	41/172 (24%)
		NEUZ	522..644	CDD:128856	23/128 (18%)
		SPRY_NHR_like	525..686	CDD:293945	33/168 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	692..717		5/30 (17%)
		NEUZ	718..840	CDD:128856	4/29 (14%)
		SPRY_NHR_like	720..884	CDD:293945	4/27 (15%)
		SPRY_NHR_like	917..1085	CDD:293945
		NEUZ	917..1043	CDD:128856
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1087..1121
		NEUZ	1131..1248	CDD:128856
		SPRY_NHR_like	1134..1293	CDD:293945
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810