DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neur and Neurl3

DIOPT Version :9

Sequence 1:	NP_476652.1	Gene:	neur / 41085	FlyBaseID:	FBgn0002932	Length:	754	Species:	Drosophila melanogaster
Sequence 2:	XP_006495909.1	Gene:	Neurl3 / 214854	MGIID:	2429944	Length:	268	Species:	Mus musculus

Alignment Length:	331	Identity:	86/331 - (25%)
Similarity:	119/331 - (35%)	Gaps:	112/331 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 LQFH-SVHGDNIRISRDGTLARRFESFCRAITFSARPVRINERICVKFAEISNNWNGGIRFGFTS 170
            |.|| :..|..:.:....:.|||..:|...|.||.|||...||:.::.......|.||:|.|||.
Mouse    32 LSFHGNATGAQVHLDDQRSTARRRSTFHDGIVFSQRPVWPGERVALRVLRHEEGWCGGLRVGFTR 96

  Fly   171 NDPVTLEGT-LPKYACPDLTNRPGFWAKALHEQYCEKDNILYYYVNGAGDVIYGINNE-----EK 229
            .||..:..: ||.:.||||..:...||..|.|.:....|::.::||..|.:...:|..     .|
Mouse    97 LDPAQVAASCLPPFVCPDLEEQSPTWAALLPEGFVRAGNVVCFWVNRRGWLFAKVNAGRPLLLRK 161

  Fly   230 GVILTGIDTRSLLWTVIDIYGNCTGIEFLDSRIYMYQQQPAAIPMATVPAQQQQMPQPAANASSA 294
            .|::.|    :.||.|:|:||....||.||                           |.|||  .
Mouse   162 DVLVQG----APLWAVMDVYGTTKAIELLD---------------------------PKANA--W 193

  Fly   295 LNSHHPHQQSRRSLPGHTAAIEHDLERHVMPSLQSLHLAGNGGSVASVEQAAIAHDLANGLPPLR 359
            :.|..|..:|                                 .|.|.|:..|.
Mouse   194 IRSGEPVPES---------------------------------EVISGEECVIC----------- 214

  Fly   360 YNANGRLIPVPFHNTKGRNVRL---SQDRFVASRTESDFCQGYVF--TAR-PI---RIGEKLIVQ 415
                       ||||  .|.||   ....|..|      |..::|  ||| ||   :|.|..:|.
Mouse   215 -----------FHNT--ANTRLMPCGHSHFCGS------CAWHIFKDTARCPICRWQIEEVAVVS 260

  Fly   416 VLKTEQ 421
            .||.|:
Mouse   261 SLKAEE 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neur	NP_476652.1	NEUZ	106..225	CDD:128856	39/119 (33%)
		SPRY	108..255	CDD:295394	48/153 (31%)
		Neuralized	109..173	CDD:284568	22/64 (34%)
		NEUZ	367..489	CDD:128856	22/64 (34%)
		SPRY	371..519	CDD:295394	22/60 (37%)
		Neuralized	371..436	CDD:284568	22/60 (37%)
		zf-C3HC4_3	700..748	CDD:290631
Neurl3	XP_006495909.1	Neuralized	34..187	CDD:369249	50/156 (32%)
Neurl3	XP_006495909.1	RING-HC_NEURL3	209..250	CDD:319466	18/70 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001576
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12429
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.870