Protein Alignment neur and Neurl1a

DIOPT Version :10

• Sequence 1: NP_476652.1
• Gene: neur / 41085
• FlyBaseID: FBgn0002932
• Length: 754
• Species: Drosophila melanogaster
• Sequence 2: NP_067335.4
• Gene: Neurl1a / 18011
• MGIID: 1334263
• Length: 574
• Species: Mus musculus
• Alignment Length: 679
• Identity: 188/679 - (27%)
• Similarity: 289/679 - (42%)
• Gaps: 180/679 - (26%)

  Fly    98 CP---GPNNLP--PLQFH-SVHGDNIRISRDGTLARRFESFCRAITFSARPVRINERICVKFAEI 156
            ||   ....||  ||.|| ...|..|.:.......:|..|||.|||||.|||.|.|::.:|..:.
Mouse    49 CPPTLSGGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKK 113

  Fly   157 SNNWNGGIRFGFTSNDPVTLE-GTLPKYACPDLTNRPGFWAKALHEQYCEKDNILYYYVNGAGDV 220
            ...|:|.:|.||||.||..:. .:|||||||||.::.|||||||.|::..:.||:.::|:..|.|
Mouse   114 QCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRV 178

  Fly   221 IYGINNEEKGVILTGIDTRSLLWTVIDIYGNCTGIEFLDSRIYMYQQQPAAIPMATVPAQQQQMP 285
            .|.||.....:..:|:.|...||.::|:||...|::.|||.:        .:|....|.....:.
Mouse   179 FYRINESAAMLFFSGVRTVDPLWALVDVYGLTRGVQLLDSEL--------VLPDCLRPRSFTALR 235

  Fly   286 QPAANASSALNSHHPHQQSRRSLPGHTAAIEHDLERHVMPSLQSLHLAGNGGSVASVEQAAIAHD 350
            :|:....:        .::|.|:                 ||..|::.|..|.
Mouse   236 RPSLRCEA--------DEARLSV-----------------SLCDLNVPGADGD------------ 263

  Fly   351 LANGLP----PLRYNA----NGRLIP------VPFHNTK-GRNVRLSQDRFVASRTESDFCQGYV 400
              :|.|    |:..|:    :.|.:|      :.||..: |.:||:..::.||........:..|
Mouse   264 --DGAPPAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARLEHGRDERALV 326

  Fly   401 FTARPIRIGEKLIVQVLKTEQMYVGALALGLTSCNPAMLQPNDLPNDSDFLLDRPEYWVVSKDIA 465
            ||:||:|:.|.:.::|.::.....|||:.|:|:|:|..|:|.|||...:.|:||.|:|.|.: :.
Mouse   327 FTSRPVRVAETIFIKVTRSGGGRAGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCR-VP 390

  Fly   466 AAPQRGDEIAFFVAPNGEVSISKNNGPAVVVMHVDQSLQLWAFLDVYGSTQSLRMFRQQLPNMVA 530
            .....||.:...|..:||:.:|.|...|.:.:.||.|..||....::|:...:|:....:.....
Mouse   391 GPLHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLFSLHGAITQVRILGSTIMTERG 455

  Fly   531 YPSQPQVNVNASSSSACNAASTSRMLPMTESMSSLNAGATAKLLHHPSQLSVAQSTSTLASAGGV 595
            .||.|           |:.|||    |.:                 ||.|.:..|...|::.|
Mouse   456 GPSLP-----------CSPAST----PTS-----------------PSALGIRLSDPLLSTCG-- 486

  Fly   596 NGSRMISMPSNGDILQIQPNGGGTV--LVVNLPPASSSHDINGQLAARPTATVTSSGVLAGACSS 658
                  |.|..|       :.|||.  ..|:||
Mouse   487 ------SGPLGG-------SAGGTAPNSPVSLP-------------------------------- 506

  Fly   659 GTLISTTSSQYIEQPIANSTNNAANKWKDSLSDQQSTDSSAECTICYENPIDSVLYMCGHMCMCY 723
                        |.|:    .....:|.|            |||||||:.:|:|:|.|||||:||
Mouse   507 ------------ESPV----TPGLGQWSD------------ECTICYEHAVDTVIYTCGHMCLCY 543

  Fly   724 DCAIEQWRGVGGGQCPLCRAVIRDVIRTY 752
            .|.:...:.: ...||:||..|:|:|:||
Mouse   544 SCGLRLKKAL-HACCPICRRPIKDIIKTY 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neur	NP_476652.1	Neuralized	109..259	CDD:462112	61/151 (40%)
		Neuralized	371..520	CDD:462112	47/149 (32%)
		mRING-HC-C3HC5_NEU1	698..752	CDD:438309	25/53 (47%)
Neurl1a	NP_067335.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		2/3 (67%)
		NEUZ	61..183	CDD:128856	53/121 (44%)
		Neuralized	296..447	CDD:462112	48/151 (32%)
		mRING-HC-C3HC5_NEU1A	515..573	CDD:438439	29/70 (41%)