DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neur and NEURL2

DIOPT Version :9

Sequence 1:	NP_476652.1	Gene:	neur / 41085	FlyBaseID:	FBgn0002932	Length:	754	Species:	Drosophila melanogaster
Sequence 2:	NP_542787.1	Gene:	NEURL2 / 140825	HGNCID:	16156	Length:	285	Species:	Homo sapiens

Alignment Length:	246	Identity:	55/246 - (22%)
Similarity:	84/246 - (34%)	Gaps:	92/246 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 FGLVRRSPSSCPGPNNLPPLQFHSVHGDNIRISRDGTLARRFESFCRAITFSARPVRINERICVK 152
            :||.|..|         ||.:||.|||.|||:...||.|.|.|||...:.||..|:...:...|:
Human    14 WGLERPEP---------PPTRFHRVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVFLVE 69

  Fly   153 FAEISNNWNGGIRFGFTSNDPVTLEGTLPKYACPDLTN--------------------------- 190
            ..|....|.|.:|.|.|:.||.:| ..:|:::.|||.|
Human    70 IEEKELGWCGHLRLGLTALDPASL-APVPEFSLPDLVNLGHTWVFAITRHHNRVPREGRPEAEAA 133

  Fly   191 ------------------------------RPGFWAKALHEQY------------------CEKD 207
                                          |||.::..|.:.|                  |.:.
Human   134 APSRPPTLLVEPYLRIEQFRIPRDRLVGRSRPGLYSHLLDQLYELNVLPPTARRSRLGVLFCPRP 198

  Fly   208 NILYYYVNGAGDVIYGINNEEKGVILTGIDTRSLLWTVIDIYGNCTGIEFL 258
                   :|..|:...||.|:.|....|:.....|:.|:|::.:...:..:
Human   199 -------DGTADMHIIINGEDMGPSARGLPAAQPLYAVVDVFASTKSVRLV 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neur	NP_476652.1	NEUZ	106..225	CDD:128856	42/193 (22%)
		SPRY	108..255	CDD:295394	49/221 (22%)
		Neuralized	109..173	CDD:284568	25/63 (40%)
		NEUZ	367..489	CDD:128856
		SPRY	371..519	CDD:295394
		Neuralized	371..436	CDD:284568
		zf-C3HC4_3	700..748	CDD:290631
NEURL2	NP_542787.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		3/5 (60%)
		SPRY_NHR_like	25..242	CDD:293945	49/224 (22%)
		SOCS_box	249..285	CDD:198037
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810