DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tgo and ARNT2

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_055677.3	Gene:	ARNT2 / 9915	HGNCID:	16876	Length:	717	Species:	Homo sapiens

Alignment Length:	710	Identity:	310/710 - (43%)
Similarity:	403/710 - (56%)	Gaps:	117/710 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEANIQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKAL 66
            |:.:.:...:| |||||.|||||||||||.|||||||||||||||||||||||||||||:|||::
Human    53 DDEDGEGPSKF-SRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSM 116

  Fly    67 RGTGNTSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGT 131
            |||||.|:||.|||||||:||||||||||||||||||:.::|||||||||||||||..||:|:|:
Human   117 RGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGS 181

  Fly   132 SLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVGNV 196
            :|||.:||||.||:||||.|.|:...|||||||:|||||||.|||||:.||:||.||||||.||.
Human   182 TLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNA 246

  Fly   197 NPESMVSGHLNRLKQ--RNSLGPSRDG-TNYAVVHCTGYIKNWPPTDM-FPNMHMERDVD-DMSS 256
            ..:.:....:..:::  ||.|||.::| ..|||||||||||.|||..| .|    |.|.| ...|
Human   247 PLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIP----EEDADVGQGS 307

  Fly   257 HCCLVAIGRLQVTST-AANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYD 320
            ..||||||||||||: ...||:|.:..:||::||..||..||||.|.::::||.|.:||||...:
Human   308 KYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILE 372

  Fly   321 FFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNSS 385
            |.|||||||::|||.||:|.|||:.|::||.|.||.|::.:||.::.|.|||:||:|||:|||::
Human   373 FCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTN 437

  Fly   386 GKTMHGAPLDAAAAHTPEQVQQQQQQEQHVYVQAAPGVDYARRELTPV----------GSATN-- 438
                               |:|.|||:..:.|....|:........||          |.:..
Human   438 -------------------VKQLQQQQAELEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEKA 483

  Fly   439 DGMYQ-------THMLAMQAPTPQQQQQQQQRPGSAQTTPVGYTYDTTHS--PYSAG-----GPS 489
            |.::.       ..|.|..:.:.::........|:.|....|..:.:.||  .:|:.     |.:
Human   484 DAIFSQERDPRFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPFPSGHSGKAFSSSVVHVPGVN 548

  Fly   490 PLAKIPKSGTSPTPVAPN------SWAALRP---------QQQQQQQQPVTEGYQYQQ------- 532
            .:.....:|.:.:.::..      :|...||         |..:.|..|...|..:..
Human   549 DIQSSSSTGQNMSQISRQLNQSQVAWTGSRPPFPGQQIPSQSSKTQSSPFGIGTSHTYPADPSSY 613

  Fly   533 ---TSPA-RSPSGPTYTQLSAGNGNRQQAQPGAYQAGPPP------PPNAPGMWDWQQAGGHPHP 587
               :||| .||||..|:.|:    ||   .||..::|...      |......|..|..|
Human   614 SPLSSPATSSPSGNAYSSLA----NR---TPGFAESGQSSGQFQGRPSEVWSQWQSQHHG----- 666

  Fly   588 PHPTAHPHHPHAHPGGPAGAGQPQGQEFSDMLQML-DHTPTT----FEDL-NINMFSTPF 641
              ..:...|.|..||        |.:.|.|||.|. |.|..|    .||. ::.|| .||
Human   667 --QQSGEQHSHQQPG--------QTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMF-PPF 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	47/51 (92%)
		PAS	87..192	CDD:279347	78/104 (75%)
		PAS	90..154	CDD:214512	47/63 (75%)
		PAS_11	283..384	CDD:291273	55/100 (55%)
		PAS	283..380	CDD:238075	52/96 (54%)
ARNT2	NP_055677.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..74		10/21 (48%)
		bHLH-PAS_ARNT	62..124	CDD:381517	54/62 (87%)
		PAS	137..243	CDD:395786	79/105 (75%)
		PAS_11	336..436	CDD:405306	55/99 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..717		45/191 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144514
Domainoid	1	1.000	166	1.000	Domainoid score	I3894
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1374
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	1	1.000	-	-		otm40426
orthoMCL	1	0.900	-	-		OOG6_105223
Panther	1	1.100	-	-	O	PTHR23042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2390
SonicParanoid	1	1.000	-	-		X1928
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790