DRSC/TRiP Functional Genomics Resources

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Protein Alignment tgo and CLOCK

DIOPT Version :10

Sequence 1:NP_731308.1 Gene:tgo / 41084 FlyBaseID:FBgn0264075 Length:642 Species:Drosophila melanogaster
Sequence 2:NP_004889.1 Gene:CLOCK / 9575 HGNCID:2082 Length:846 Species:Homo sapiens


Alignment Length:835 Identity:173/835 - (20%)
Similarity:276/835 - (33%) Gaps:319/835 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DEANI-------QDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMA 59
            |:::|       .||:: |.|.:..:.|::||::....|.||..|:|   ..|||.||.|:|:.:
Human    17 DDSSIFDGLVEEDDKDK-AKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKS 77

  Fly    60 VAHMKALRGTGNTSSDGT-----YKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTP 119
            :..::..:.. ...||.:     :||:||:::|...|:|||.|||...:..| |.:||||:|||.
Human    78 IDFLRKHKEI-TAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTD-GSIIYVSESVTS 140

  Fly   120 VLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGAR 184
            :|.:..||....|::..|...:..::.:.|||..         |:|.::..|..:|..:|.    
Human   141 LLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHL---------LESDSLTPEYLKSKNQLE---- 192

  Fly   185 RGFICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMER 249
              |.|.|..|.::|                    ::.:.|..|...|..|:........:...|.
Human   193 --FCCHMLRGTIDP--------------------KEPSTYEYVKFIGNFKSLNSVSSSAHNGFEG 235

  Fly   250 DVD-----DMSSHCCLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYT 309
            .:.     ......|.||..||..........:......||.:||:::.||.|:|.|...|:||.
Human   236 TIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYL 300

  Fly   310 PTELLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTD 374
            |.|:||...||::|.:|..::.:..:. |.|.|:..|..||...|..:::||:|..|...:.:..
Human   301 PFEVLGTSGYDYYHVDDLENLAKCHEH-LMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNS 364

  Fly   375 EVEYIVCTN-------------------------------------------------------- 383
            ..|:||||:                                                        
Human   365 RPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAADKSQDSGSDNRINTVSLKEALERFDHSPT 429

  Fly   384 ------SSGKTMHGA-----------PLD------------------------------------ 395
                  ||.|:.|.|           |.|                                    
Human   430 PSASSRSSRKSSHTAVSDPSSTPTKIPTDTSTPPRQHLPAHEKMVQRRSSFSSQSINSQSVGSSL 494

  Fly   396 --------------------------AAAAHTPEQVQQ----------QQQQE------------ 412
                                      .|..|..:|::|          :||:|            
Human   495 TQPVMSQATNLPIPQGMSQFQFSAQLGAMQHLKDQLEQRTRMIEANIHRQQEELRKIQEQLQMVH 559

  Fly   413 ----QHVYVQAAPGVDYAR-----------RELTPVG------------SATNDGMYQT--HML- 447
                |....|:.||:::..           ::|.|:.            |..|.|...|  ||: 
Human   560 GQGLQMFLQQSNPGLNFGSVQLSSGNSSNIQQLAPINMQGQVVPTNQIQSGMNTGHIGTTQHMIQ 624

  Fly   448 --AMQAPTPQQQQ-------QQQQRPGSAQTTPVGYTYDTTHSPYSAGG-----PSPLAKIPKSG 498
              .:|:.:.|.||       ||...|...|:|.....|:|......|.|     ||   .:|::.
Human   625 QQTLQSTSTQSQQNVLSGHSQQTSLPSQTQSTLTAPLYNTMVISQPAAGSMVQIPS---SMPQNS 686

  Fly   499 TSPTPV-----------------------AP------------------NSWAALRPQQQQQQ-- 520
            |....|                       ||                  .::.....||||.|  
Human   687 TQSAAVTTFTQDRQIRFSQGQQLVTKLVTAPVACGAVMVPSTMLMGQVVTAYPTFATQQQQSQTL 751

  Fly   521 ---QQPVTEGYQYQQTSPARSPSGPTYTQ----------LSAGNGNRQQAQPGAY 562
               ||...:..|.||.:..:.||....||          |..||.:.|.....|:
Human   752 SVTQQQQQQSSQEQQLTSVQQPSQAQLTQPPQQFLQTSRLLHGNPSTQLILSAAF 806

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tgoNP_731308.1 bHLH-PAS_ARNT 9..74 CDD:381517 18/64 (28%)
PAS 90..154 CDD:214512 24/63 (38%)
PAS_11 282..384 CDD:464214 36/163 (22%)
CLOCKNP_004889.1 bHLH-PAS_CLOCK 29..89 CDD:381577 19/64 (30%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O08785 32..47 3/15 (20%)
PAS 109..>175 CDD:395786 25/75 (33%)
PAS_11 274..377 CDD:464214 36/103 (35%)
Interaction with NR3C1. /evidence=ECO:0000250|UniProtKB:O08785 371..845 67/439 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..411 0/18 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..495 7/74 (9%)
Interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:O08785 450..570 10/119 (8%)
Implicated in the circadian rhythmicity. /evidence=ECO:0000250 514..564 7/49 (14%)
SP1-4_N 550..>694 CDD:425404 30/146 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 624..654 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 764..783 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 811..846
Blue background indicates that the domain is not in the aligned region.

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