DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tgo and CLOCK

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_001254772.1	Gene:	CLOCK / 9575	HGNCID:	2082	Length:	846	Species:	Homo sapiens

Alignment Length:	835	Identity:	173/835 - (20%)
Similarity:	276/835 - (33%)	Gaps:	319/835 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEANI-------QDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMA 59
            |:::|       .||:: |.|.:..:.|::||::....|.||..|:|   ..|||.||.|:|:.:
Human    17 DDSSIFDGLVEEDDKDK-AKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKS 77

  Fly    60 VAHMKALRGTGNTSSDGT-----YKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTP 119
            :..::..:.. ...||.:     :||:||:::|...|:|||.|||...:..| |.:||||:|||.
Human    78 IDFLRKHKEI-TAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTD-GSIIYVSESVTS 140

  Fly   120 VLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGAR 184
            :|.:..||....|::..|...:..::.:.|||..         |:|.::..|..:|..:|.
Human   141 LLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHL---------LESDSLTPEYLKSKNQLE---- 192

  Fly   185 RGFICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMER 249
              |.|.|..|.::|                    ::.:.|..|...|..|:........:...|.
Human   193 --FCCHMLRGTIDP--------------------KEPSTYEYVKFIGNFKSLNSVSSSAHNGFEG 235

  Fly   250 DVD-----DMSSHCCLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYT 309
            .:.     ......|.||..||..........:......||.:||:::.||.|:|.|...|:||.
Human   236 TIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYL 300

  Fly   310 PTELLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTD 374
            |.|:||...||::|.:|..::.:..:. |.|.|:..|..||...|..:::||:|..|...:.:..
Human   301 PFEVLGTSGYDYYHVDDLENLAKCHEH-LMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNS 364

  Fly   375 EVEYIVCTN-------------------------------------------------------- 383
            ..|:||||:
Human   365 RPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAADKSQDSGSDNRINTVSLKEALERFDHSPT 429

  Fly   384 ------SSGKTMHGA-----------PLD------------------------------------ 395
                  ||.|:.|.|           |.|
Human   430 PSASSRSSRKSSHTAVSDPSSTPTKIPTDTSTPPRQHLPAHEKMVQRRSSFSSQSINSQSVGSSL 494

  Fly   396 --------------------------AAAAHTPEQVQQ----------QQQQE------------ 412
                                      .|..|..:|::|          :||:|
Human   495 TQPVMSQATNLPIPQGMSQFQFSAQLGAMQHLKDQLEQRTRMIEANIHRQQEELRKIQEQLQMVH 559

  Fly   413 ----QHVYVQAAPGVDYAR-----------RELTPVG------------SATNDGMYQT--HML- 447
                |....|:.||:::..           ::|.|:.            |..|.|...|  ||:
Human   560 GQGLQMFLQQSNPGLNFGSVQLSSGNSSNIQQLAPINMQGQVVPTNQIQSGMNTGHIGTTQHMIQ 624

  Fly   448 --AMQAPTPQQQQ-------QQQQRPGSAQTTPVGYTYDTTHSPYSAGG-----PSPLAKIPKSG 498
              .:|:.:.|.||       ||...|...|:|.....|:|......|.|     ||   .:|::.
Human   625 QQTLQSTSTQSQQNVLSGHSQQTSLPSQTQSTLTAPLYNTMVISQPAAGSMVQIPS---SMPQNS 686

  Fly   499 TSPTPV-----------------------AP------------------NSWAALRPQQQQQQ-- 520
            |....|                       ||                  .::.....||||.|
Human   687 TQSAAVTTFTQDRQIRFSQGQQLVTKLVTAPVACGAVMVPSTMLMGQVVTAYPTFATQQQQSQTL 751

  Fly   521 ---QQPVTEGYQYQQTSPARSPSGPTYTQ----------LSAGNGNRQQAQPGAY 562
               ||...:..|.||.:..:.||....||          |..||.:.|.....|:
Human   752 SVTQQQQQQSSQEQQLTSVQQPSQAQLTQPPQQFLQTSRLLHGNPSTQLILSAAF 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	16/51 (31%)
		PAS	87..192	CDD:279347	32/104 (31%)
		PAS	90..154	CDD:214512	24/63 (38%)
		PAS_11	283..384	CDD:291273	36/162 (22%)
		PAS	283..380	CDD:238075	32/96 (33%)
CLOCK	NP_001254772.1	HLH	32..86	CDD:238036	17/57 (30%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O08785	32..47		3/15 (20%)
		PAS	109..>175	CDD:307226	25/75 (33%)
		PAS_3	274..377	CDD:330807	36/103 (35%)
		Interaction with NR3C1. /evidence=ECO:0000250\|UniProtKB:O08785	371..845		67/439 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..411		0/18 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..495		7/74 (9%)
		Interaction with SIRT1. /evidence=ECO:0000250\|UniProtKB:O08785	450..570		10/119 (8%)
		Med15	<496..>686	CDD:312941	35/192 (18%)
		Implicated in the circadian rhythmicity. /evidence=ECO:0000250	514..564		7/49 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..654		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..783		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	811..846
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144513
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840