DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tgo and PER3

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_001276791.1	Gene:	PER3 / 8863	HGNCID:	8847	Length:	1210	Species:	Homo sapiens

Alignment Length:	868	Identity:	150/868 - (17%)
Similarity:	249/868 - (28%)	Gaps:	339/868 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ERFASRENHCEIERRRR--NKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRGTGN- 71
            :|..:..:|.|.:.|.|  .::...:.|:....|  |....||..|..|..|:..:.:::....
Human    34 QRKLADSSHSEQQDRNRVSEELIMVVQEMKKYFP--SERRNKPSTLDALNYALRCVHSVQANSEF 96

  Fly    72 ---TSSDGTYKP--SFLTDQELKHLILE----AADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSD 127
               .|.:|..:.  |..:.:||..:..|    ..|.|:.|.|..|||::::|:....:||..:..
Human    97 FQILSQNGAPQADVSMYSLEELATIASEHTSKNTDTFVAVFSFLSGRLVHISEQAALILNRKKDV 161

  Fly   128 WYGTSLYEHIHPDD-----REKIREQLS-----TQESQNAGRILDLKSGTVKKEGHQSSMRLSMG 182
            ...:...:.:.|.|     ....|.||.     ||                     :::.|....
Human   162 LASSHFVDLLAPQDMRVFYAHTARAQLPFWNNWTQ---------------------RAAARYECA 205

  Fly   183 ARRGFICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFP---N 244
            ..:.|.||:|.|...            ||.....|.|                     :.|   :
Human   206 PVKPFFCRIRGGEDR------------KQEKCHSPFR---------------------IIPYLIH 237

  Fly   245 MHMERDVDDMSSHCCLVAIGRLQVTSTAANDMSGSN------NQSEFITRHAMDGKFTFVDQRVL 303
            :|.....:..|..|||..:.::.         ||..      |:..|.|.|.....|..||::.:
Human   238 VHHPAQPELESEPCCLTVVEKIH---------SGYEAPRIPVNKRIFTTTHTPGCVFLEVDEKAV 293

  Fly   304 NILGYTPTELLGKICYDFFHPEDQSHMKESFDQVLKQKGQ--MFSLLYRARAKNSEYVWLRTQAY 366
            .:|||.|.:|:|.....:.||||:|.|.....:|||..|.  ......|...:|.:|:.|.:...
Human   294 PLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPIRFCTQNGDYIILDSSWS 358

  Fly   367 AFLNPYTDEVEYIV---------------------------------------------CTNSSG 386
            :|:||::.::.:|:                                             .:.|||
Human   359 SFVNPWSRKISFIIGRHKVRTSPLNEDVFATKIKKMNDNDKDITELQEQIYKLLLQPVHVSVSSG 423

  Fly   387 KTMHG-----------APLDAAAAHTPEQVQQQQQQEQHVYV-------------------QAAP 421
            ....|           |....|:.|..|:.:.:|...|.||.                   .:..
Human   424 YGSLGSSGSQEQLVSIASSSEASGHRVEETKAEQMTLQQVYASVNKIKNLGQQLYIESMTKSSFK 488

  Fly   422 GVDYARRELTPVGSATNDG--------MYQT------------------HMLAMQ---------- 450
            .|...|.|....|.:.|.|        .:||                  |..:.|
Human   489 PVTGTRTEPNGGGESANGGGECKTFTSFHQTLKNNSVYTEPCEDLRNDEHSPSYQQINCIDSVIR 553

  Fly   451 --------------------APTPQQQQQQQQRPGSAQTTPVGY--------TYDTTHSPYSAGG 487
                                ..:..::.:|..:....|....|.        ...|.......||
Human   554 YLKSYNIPALKRKCISCTNTTSSSSEEDKQNHKADDVQALQAGLQIPAIPKSEMPTNGRSIDTGG 618

  Fly   488 PSP----------------------LAKIPKSGTS---------------PTPVAPNSW------ 509
            .:|                      :..:|...|:               |.|:....:
Human   619 GAPQILSTAMLSLGSGISQCGYSSTIVHVPPPETARDATLFCEPWTLNMQPAPLTSEEFKHVGLT 683

  Fly   510 -AALRPQQQQQQQQPVTE----------------------GYQY-------QQTSPA-------- 536
             |.|....|:::|..|.:                      .|.|       :||..|
Human   684 AAVLSAHTQKEEQNYVDKFREKILSSPYSSYLQQESRSKAKYSYFQGDSTSKQTRSAGCRKGKHK 748

  Fly   537 --RSPSGPTYTQLSAGNGNRQQAQPGAYQAGPPPPPNAPGMWDWQQAGGHPHPPHPTAHP----- 594
              :.|..|..:..:.|:|.|:    ||:|...|..|:         |...||...||..|
Human   749 RKKLPEPPDSSSSNTGSGPRR----GAHQNAQPCCPS---------AASSPHTSSPTFPPAAMVP 800

  Fly   595 -HHPHAHPGGPAGAGQPQGQEFS 616
             ..|:..|..|..|....|:|::
Human   801 SQAPYLVPAFPLPAATSPGREYA 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	12/53 (23%)
		PAS	87..192	CDD:279347	24/118 (20%)
		PAS	90..154	CDD:214512	18/77 (23%)
		PAS_11	283..384	CDD:291273	30/147 (20%)
		PAS	283..380	CDD:238075	29/98 (30%)
PER3	NP_001276791.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		4/15 (27%)
		Nuclear export signal 1. /evidence=ECO:0000250	55..64		1/8 (13%)
		PAS	285..377	CDD:238075	27/91 (30%)
		Nuclear export signal 3. /evidence=ECO:0000250	404..413		0/8 (0%)
		CSNK1E binding domain. /evidence=ECO:0000250	563..768		25/204 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..796		20/83 (24%)
		Nuclear localization signal. /evidence=ECO:0000250	737..753		2/15 (13%)
		Herpes_BLLF1	<756..1066	CDD:282904	21/81 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..931
		Nuclear export signal 2. /evidence=ECO:0000250	933..940
		5 X 18 AA tandem repeats of S-[HP]-[AP]-T-[AT]-[GST]-[ATV]-L-S-[MT]-G-[LS]-P-P-[MRS]- [EKR]-[NST]-P	974..1063
		Period_C	<1083..1198	CDD:403366
		CRY binding domain. /evidence=ECO:0000250	1132..1210
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331262at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920