DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tgo and NCOA3

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_858045.1	Gene:	NCOA3 / 8202	HGNCID:	7670	Length:	1424	Species:	Homo sapiens

Alignment Length:	693	Identity:	156/693 - (22%)
Similarity:	234/693 - (33%)	Gaps:	244/693 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 CEIERRRRNKMTAYITELSDMVPT----CSALARKPDKLTILRMAVAHMKALRGTGNTSS--DGT 77
            |..|:|||.:.:.||.||::::..    ......||||..||:..|..::.::..|.|.|  |..
Human    31 CSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDV 95

  Fly    78 YK-------PSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYE 135
            .|       ...:....|..|:|:|.|||||||:.| |.:::||::||..|.|.|.|...||:|.
Human    96 QKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRD-GNIVFVSENVTQYLQYKQEDLVNTSVYN 159

  Fly   136 HIHPDDREKIREQLS---------TQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRM 191
            .:|.:||:...:.|.         |.|:|             :::.|.            |.|||
Human   160 ILHEEDRKDFLKNLPKSTVNGVSWTNETQ-------------RQKSHT------------FNCRM 199

  Fly   192 RVG---------NVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHM 247
            .:.         |.:||         ::||           |..:.|....:        |...|
Human   200 LMKTPHDILEDINASPE---------MRQR-----------YETMQCFALSQ--------PRAMM 236

  Fly   248 ERDVDDMSSHCCLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTE 312
            | :.:|:.|  |::.:.| ::|:   .:.:..:|...|||||.:.||...:|...|
Human   237 E-EGEDLQS--CMICVAR-RITT---GERTFPSNPESFITRHDLSGKVVNIDTNSL--------- 285

  Fly   313 LLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAY--AFLNPYTDE 375
                          :|.|:..|:.::::..|.|..|      |....|.:.:.|  |:||.:.:.
Human   286 --------------RSSMRPGFEDIIRRCIQRFFSL------NDGQSWSQKRHYQEAYLNGHAET 330

  Fly   376 VEY--------IVCTNSSGKTMHGAPLDAAAAHTPEQVQQQQQQEQHVYVQAAPGVDYARRELTP 432
            ..|        ||...:..|...                                        .|
Human   331 PVYRFSLADGTIVTAQTKSKLFR----------------------------------------NP 355

  Fly   433 VGSATND--GMYQTHMLAMQAPTPQQQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGGPSPLAKIP 495
            |   |||  |...||.|        |::|...||   ...|||           .|...|:|..
Human   356 V---TNDRHGFVSTHFL--------QREQNGYRP---NPNPVG-----------QGIRPPMAGC- 394

  Fly   496 KSGTSPTPVAPNSWAALRPQQQQQQQQPVTEGYQYQQTSPARSPSGPTYTQLSAGNGNRQQAQPG 560
            .|......::||....:...:......|.|.|    |.|.||.........|:.|.|   ...|.
Human   395 NSSVGGMSMSPNQGLQMPSSRAYGLADPSTTG----QMSGARYGGSSNIASLTPGPG---MQSPS 452

  Fly   561 AYQAG------PPPPPNAPGMWDWQQ-------AGGHP----HPPHPTAHPHHPHAHPGGPA--- 605
            :||..      ..||..:||:...||       ..|.|    |...|.|..|.|.|..|...
Human   453 SYQNNNYGLNMSSPPHGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHS 517

  Fly   606 --------------GAGQPQGQEFSDMLQMLDHTPTTFEDLNI 634
                          |.|.......|.....||::|    ::||
Human   518 FSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSP----NMNI 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	16/51 (31%)
		PAS	87..192	CDD:279347	35/113 (31%)
		PAS	90..154	CDD:214512	28/72 (39%)
		PAS_11	283..384	CDD:291273	24/110 (22%)
		PAS	283..380	CDD:238075	22/106 (21%)
NCOA3	NP_858045.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		3/6 (50%)
		HLH	34..88	CDD:197674	16/53 (30%)
		PAS	116..173	CDD:214512	26/57 (46%)
		PAS	117..215	CDD:279347	35/123 (28%)
		PAS_11	265..375	CDD:291273	36/189 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..493		21/91 (23%)
		NCOA_u2	459..572	CDD:293270	23/102 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..520		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..674		6/24 (25%)
		SRC-1	620..704	CDD:285981
		LXXLL motif 1	685..689
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..730
		DUF4927	723..810	CDD:292896
		LXXLL motif 2	738..742
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..798
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..945
		Interaction with CREBBP. /evidence=ECO:0000269\|PubMed:9346901	1023..1093
		Nuc_rec_co-act	1045..1092	CDD:285967
		LXXLL motif 3	1057..1061
		Acetyltransferase	1097..1304
		polyglutamine repeats	1248..1276
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1273..1321
		DUF1518	1291..1348	CDD:284808
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810