Protein Alignment tgo and ncoa2

DIOPT Version :10

• Sequence 1: NP_731308.1
• Gene: tgo / 41084
• FlyBaseID: FBgn0264075
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_571852.1
• Gene: ncoa2 / 81884
• ZFINID: ZDB-GENE-010406-3
• Length: 1505
• Species: Danio rerio
• Alignment Length: 638
• Identity: 148/638 - (23%)
• Similarity: 224/638 - (35%)
• Gaps: 174/638 - (27%)

  Fly    22 ERRRRNKMTAYITELSDMVPTCSALAR---------KPDKLTILRMAVAHMKALR---------- 67
            |:|.|...:.||.||::::     .|.         ||||..||:..|..::.::
Zfish    36 EKRNREHESKYIEELAELI-----FANFNDIDNFNVKPDKCAILKETVKQIRQIKEQEKAAAANE 95

  Fly    68 ---GTGNTSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWY 129
               ...:.||.|   .|.:....|..::|||.|||.|||:.: |.:::||::||..|.|.|.:..
Zfish    96 DEVQKADVSSTG---QSVIDKDALGPMMLEALDGFFFVVNME-GNIVFVSENVTQYLRYNQEELM 156

  Fly   130 GTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVG 194
            .||:|..:|..|..:..:.|..:...|.   :...|...::..|.            |.|||.
Zfish   157 NTSVYSILHVGDHAEFIKNLLPKSHVNG---VPWSSENPRRNSHT------------FNCRML-- 204

  Fly   195 NVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMERDVDDMSSHCC 259
             |||.|......:...|:          .|..:.|  :..:.|.:       ::.:.:|..|  |
Zfish   205 -VNPHSEAEETQDHEAQQ----------KYETMQC--FAVSEPKS-------IKEEGEDFQS--C 247

  Fly   260 LVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFHP 324
            |:.:.|    .....:......|..|.||..:.||.|.:|..:|........|.|.:.|...||.
Zfish   248 LICVAR----RVPMKERPMLPTQESFTTRQDLQGKITSLDTSLLRASMKPGWEDLVRRCIQRFHL 308

  Fly   325 E---DQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNSSG 386
            :   |.|..|....:|::. ||.||.:||....:...|
Zfish   309 QNDGDISFAKRHQQEVIRH-GQAFSPIYRFSLSDGTIV--------------------------- 345

  Fly   387 KTMHGAPLDAAAAHTPEQ-VQQQQQQEQHVYVQAAPGVDYARRELTPVGSATNDGMYQTHMLAMQ 450
                       :|||..: |:.....|..:|:    .:...:||....|.|::.|..||
Zfish   346 -----------SAHTKSKLVRSSSTNEPQLYM----SLHILQREQPVCGMASDLGNAQT------ 389

  Fly   451 APTPQQQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGGPSPLAKIPKSGTSPTPVAPNSW---AAL 512
            ...|..........||: .||.|  .|.|.|..::..|||       |....|.|.:.:   ..:
Zfish   390 MGKPMNPMSSPNTAGSS-CTPQG--QDATISSNTSTFPSP-------GAQKEPGAMHRFGCPGTM 444

  Fly   513 RPQQQQQQQQPVTEGYQYQQTSPARSPSGPTYTQLSAGNGNRQQAQPGAYQAGPP--PPPNAPGM 575
            ......|...|...||..:.:||::...|    .||.    |.:|.||.  ||.|  |||..
Zfish   445 SHSATMQAATPQGSGYPLKLSSPSQGSPG----MLSP----RHRASPGV--AGSPRLPPPQF--- 496

  Fly   576 WDWQQAGGHPHPPHPTAHPHHP----HAHPGGPAGAGQPQGQEFSDM--LQML 622
                         .|....|.|    .:..||..|||...|...|.:  ||.|
Zfish   497 -------------SPAGSLHSPASMCTSSTGGNGGAGANHGYTSSSLNALQAL 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_731308.1	bHLH-PAS_ARNT	9..74	CDD:381517	15/73 (21%)
		PAS	90..154	CDD:214512	23/63 (37%)
		PAS_11	282..384	CDD:464214	25/104 (24%)
ncoa2	NP_571852.1	basic helix-loop-helix DNA-binding domain	18..86		15/54 (28%)
		bHLH-PAS_NCoA2_SRC2	29..92	CDD:381520	15/60 (25%)
		PAS	119..176	CDD:214512	22/57 (39%)
		PAS A domain	125..184		20/59 (34%)
		PAS_11	266..375	CDD:464214	32/151 (21%)
		PAS B domain	269..330		18/61 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..515		37/158 (23%)
		NCOA_u2	460..558	CDD:465223	29/103 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..562
		SRC-1	625..705	CDD:462615
		NR Box	630..634
		NR Box	686..690
		DUF4927	728..803	CDD:465083
		NR Box	742..746
		Med15	831..>1217	CDD:312941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	835..871
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..962
		Nuc_rec_co-act	1061..1105	CDD:462608
		LLXXLXXXL motif. /evidence=ECO:0000255	1069..1077
		PABP-1234	<1080..1239	CDD:130689
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1246..1265
		HAT-like domain	1310..1378
		DUF1518	1354..1410	CDD:462174
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1475..1505