DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tgo and arnt2

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	XP_009301213.1	Gene:	arnt2 / 64277	ZFINID:	ZDB-GENE-001207-3	Length:	738	Species:	Danio rerio

Alignment Length:	716	Identity:	328/716 - (45%)
Similarity:	420/716 - (58%)	Gaps:	135/716 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRGTGNT 72
            ||||:| ||||.|||||||||||.|||||||||||||||||||||||||||||:|||::||||||
Zfish    74 DKERYA-RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTGNT 137

  Fly    73 SSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHI 137
            |:||.|||||||:||||||||||||||||||:.::|||||||||||||||:.||:|:|::|:|.:
Zfish   138 STDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNHPQSEWFGSTLFEQV 202

  Fly   138 HPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESMV 202
            ||||.:|:||||||.|:...|||||||:|||||||.|||||:.||:||.||||||.|:. |...:
Zfish   203 HPDDVDKLREQLSTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSA-PLDHI 266

  Fly   203 SGHLNRL-----KQRNSLGPSRDG-TNYAVVHCTGYIKNWPPTDM-FPNMHMERDVDDMSSHCCL 260
            |  ||||     :.||.||||::| ..|:|||||||||.|||..| .|:...|.   ..:|..||
Zfish   267 S--LNRLSSMRKRYRNGLGPSKEGEAQYSVVHCTGYIKAWPPAGMTIPDEDTEA---GQTSKYCL 326

  Fly   261 VAIGRLQVTSTAAN-DMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFHP 324
            ||||||||||:..: ||:|.:..:||::||..||..||||.|.:|::||.|.:||||...:|.||
Zfish   327 VAIGRLQVTSSPVSMDMNGLSVPTEFLSRHNSDGIITFVDPRCINVIGYQPQDLLGKDILEFCHP 391

  Fly   325 EDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNSSGKTM 389
            |||||::|||.||:|.|||:.|::||.|.||.|::.:||.::.|.|||:||:|||:|||::.|
Zfish   392 EDQSHLRESFQQVVKLKGQVLSVMYRFRMKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVK-- 454

  Fly   390 HGAPLDAAAAHTPEQVQQQQQQEQHVYVQAAPGVDYARRELTPVGSATNDGMYQ-------THML 447
                          |:|||||.|..|:.:  .|:........|| |..:.|:::       |..|
Zfish   455 --------------QLQQQQQAELEVHQR--DGLTAYDLSQVPV-SGVSAGVHESGKSIDKTESL 502

  Fly   448 AMQAPTPQ---------QQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGG-----PSPLAKIP--- 495
            ..|...|:         ..:::...|.|   |..|....:..||:..|.     .|.:..:|
Zfish   503 FSQERDPRFSDIYTGISTSEKKMMVPSS---TSGGQQLYSQGSPFQPGHSGKSFSSSVIHVPGVN 564

  Fly   496 -------KSGTSPTPVAPN------SWAALRPQQQQQQQQP------------VTEGYQYQQ--- 532
                   .:|.:.:.::..      ||:..||....|||.|            :...:.||.
Zfish   565 DIQSTAGSAGQNLSQISRQINTGQVSWSGNRPPFSGQQQIPAQSNKAQSSPFGIGSSHSYQADPS 629

  Fly   533 -----TSPA-RSPSGPTYTQLSAGNG----NRQQAQPGAYQAGPPPPPNAPGMW-DWQ-----QA 581
                 :||| .||||..|:.|:..|.    :.:.:|.|....|.|..     :| .||     |.
Zfish   630 SYSPLSSPATSSPSGNAYSNLANRNTAFDVSGESSQSGGQFQGRPSE-----VWSQWQSQHHSQQ 689

  Fly   582 GGHPHPPHPTAHPHHPHAHPGGPAGAGQPQGQEFSDMLQML-DHTPTT----FEDL-NINMFSTP 640
            .|.|||        |..|          .|.:.|.|||.|. |.|..|    .||. ::.|| .|
Zfish   690 AGDPHP--------HTQA----------SQTEVFQDMLPMPGDPTQGTTNYNIEDFADLGMF-PP 735

  Fly   641 F 641
            |
Zfish   736 F 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	47/51 (92%)
		PAS	87..192	CDD:279347	77/104 (74%)
		PAS	90..154	CDD:214512	46/63 (73%)
		PAS_11	283..384	CDD:291273	56/100 (56%)
		PAS	283..380	CDD:238075	53/96 (55%)
arnt2	XP_009301213.1	HLH	80..132	CDD:278439	47/51 (92%)
		PAS	152..258	CDD:279347	78/105 (74%)
		PAS	155..219	CDD:214512	46/63 (73%)
		PAS_11	351..451	CDD:291273	56/99 (57%)
		PAS	351..447	CDD:238075	53/95 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577641
Domainoid	1	1.000	164	1.000	Domainoid score	I3898
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	503	1.000	Inparanoid score	I1313
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	1	1.000	-	-		otm25762
orthoMCL	1	0.900	-	-		OOG6_105223
Panther	1	1.100	-	-	O	PTHR23042
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1928
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900