DRSC/TRiP Functional Genomics Resources

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Protein Alignment tgo and Clock

DIOPT Version :10

Sequence 1:NP_731308.1 Gene:tgo / 41084 FlyBaseID:FBgn0264075 Length:642 Species:Drosophila melanogaster
Sequence 2:NP_001376183.1 Gene:Clock / 60447 RGDID:620271 Length:864 Species:Rattus norvegicus


Alignment Length:883 Identity:185/883 - (20%)
Similarity:292/883 - (33%) Gaps:336/883 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DEANI-------QDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMA 59
            |:::|       .||:: |.|.:..:.|::||::....|.||..|:|   ..|||.||.|:|:.:
  Rat    17 DDSSIFDGLVEEDDKDK-AKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKS 77

  Fly    60 VAHMKALRGTGNTSSDGT-----YKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTP 119
            :..::..:.. ...||.:     :||:||:::|...|:|||.|||...:..| |.|:|||::||.
  Rat    78 IDFLRKHKEI-TAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTD-GSVVYVSETVTS 140

  Fly   120 VLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGAR 184
            :|.:..||....|::..|...:..::.:.|||..         |:|.::..|..:|..:|.    
  Rat   141 LLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHL---------LESDSLTPEDLKSKNQLE---- 192

  Fly   185 RGFICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMER 249
              |.|.|..|.::|                    ::.:.|..|...|..|:........:...|.
  Rat   193 --FCCHMLRGTIDP--------------------KEPSTYEYVRFIGNFKSLNSVSTSTHNGFEG 235

  Fly   250 DVD-----DMSSHCCLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYT 309
            .:.     ......|.||..||..........:......||.:||:::.||.|:|.|...|:||.
  Rat   236 TIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYL 300

  Fly   310 PTELLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTD 374
            |.|:||...||::|.:|...:.:..:. |.|.|:..|..||...|..:::||:|..|...:.:..
  Rat   301 PFEVLGTSGYDYYHVDDLESLAKCHEH-LMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNS 364

  Fly   375 EVEYIVCTN-------------------------------------------------------- 383
            ..|:||||:                                                        
  Rat   365 RPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAADKSQDSGSDNRINTVSLKEALERFDHSPT 429

  Fly   384 ------SSGKTMHGA-----------PLD------------------------------------ 395
                  ||.|:.|.|           |.|                                    
  Rat   430 PSASSRSSRKSSHTAVSDPSSTPTKIPTDTSTPPRPHLPAHEKMTQRRSSFSSQSINSQSVGSSL 494

  Fly   396 --------------------------AAAAHTPEQVQQ----------QQQQE------------ 412
                                      .|..|..:|::|          :||:|            
  Rat   495 TQPAMSQAANLPIPQGMSQFQLSAQLGAMQHLKDQLEQRTRMIEANIHRQQEELRKIQEQLQMVH 559

  Fly   413 ----QHVYVQAAPGVDYAR----------RELTPVG------------SATNDGMYQT--HMLAM 449
                |....|:.||:::..          ::|||:.            |..|.|...|  ||:..
  Rat   560 GQGLQMFLQQSNPGLNFGSVQLSSGNSNIQQLTPINMQGQVVPVNQIQSGVNAGHVSTGQHMIQQ 624

  Fly   450 QA--PTPQQQQQQQQRPGSAQTTPV-GYTYDTTHSPY---------SAGGPSPL-AKIPKSGTSP 501
            |.  .|..||.||....|.:|.|.: ..|..|..:|.         :||...|: :.:|::.|..
  Rat   625 QTLQSTSTQQSQQSVMSGHSQPTSLPNQTPSTLTAPLYNTMVISQPAAGSMVPIPSSMPQNSTQS 689

  Fly   502 TPV-----------------------AP------------------NSWAALRPQQQQQQQQPVT 525
            ..|                       ||                  .::.....||||.|...||
  Rat   690 ATVTTFTQDRQIRFSQGQQLVTKLVTAPVACGAVMVPSTMLMGQVVTAYPTFATQQQQAQALSVT 754

  Fly   526 EGYQYQQTSPARSPSGPTYTQLSAGNGNRQQAQPGAYQAGPPPPPNAPGMWDWQQAGGHPHPPHP 590
            :..|.||....:                :||.||  .||.|.|          |........|||
  Rat   755 QQQQQQQQQQQQ----------------QQQQQP--QQAQPQP----------QSQQSSQDQPHP 791

  Fly   591 TAHPHHPHAHPGGPAGAGQPQGQEFSDMLQMLDHTPTT 628
            :...         ||...||. |:|....::|...|:|
  Rat   792 SVQQ---------PAQLTQPP-QQFLQTSRLLHGNPST 819

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tgoNP_731308.1 bHLH-PAS_ARNT 9..74 CDD:381517 18/64 (28%)
PAS 90..154 CDD:214512 23/63 (37%)
PAS_11 282..384 CDD:464214 36/163 (22%)
ClockNP_001376183.1 bHLH-PAS_CLOCK 29..89 CDD:381577 19/64 (30%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O08785 32..47 3/15 (20%)
PAS 109..202 CDD:395786 33/108 (31%)
PAS_11 274..377 CDD:464214 36/103 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..497 7/108 (6%)
Interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:O08785 450..570 10/119 (8%)
Implicated in the circadian rhythmicity. /evidence=ECO:0000250 514..564 7/49 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 824..864
Blue background indicates that the domain is not in the aligned region.

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