DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tgo and ncoa1

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	XP_021324335.1	Gene:	ncoa1 / 563288	ZFINID:	ZDB-GENE-041001-175	Length:	1349	Species:	Danio rerio

Alignment Length:	741	Identity:	162/741 - (21%)
Similarity:	261/741 - (35%)	Gaps:	211/741 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDEANIQDKERFASRENHCE-----IERRRRNKMTAYITELSDMVPT----CSALARKPDKLTIL 56
            :|...::.::|   :.:.|:     :|:|||.....||.||::::..    .::|..||||..||
Zfish    12 LDPNILESRKR---KGSPCDTSGPSVEKRRRELECRYIDELAELLSANMSDIASLNVKPDKCHIL 73

  Fly    57 RMAVAHMKAL--RGTGNTS----------SDGTYKPSFLTDQE-LKHLILEAADGFLFVVSCDSG 108
            :..|..::.:  |...|.:          ||.:.....:.::| |..|:|||.|||.|||:.: |
Zfish    74 KSTVDQIQQIKRREQENAALMSPNDEVQQSDISSSSHGMVEKEALGPLLLEALDGFFFVVNRE-G 137

  Fly   109 RVIYVSDSVTPVLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQE-------SQNAGRILDLKSG 166
            |:::||::||..|.|||.:...:|:|..:|..|..:....|..:.       ||..||
Zfish   138 RIVFVSENVTGYLGYTQEELMTSSVYSILHVGDHNEFVRILLPKSLVNGVPWSQEQGR------- 195

  Fly   167 TVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTG 231
               :..|.            |.||:.   ..|...|.......:|:           |.::.|
Zfish   196 ---RNSHT------------FNCRLL---KRPPDEVDSENQEARQQ-----------YELMQC-- 229

  Fly   232 YIKNWPPTDMFPNMHMERDVDDMSSHCCLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFT 296
            :..:.|..       ::.:.:|:.|  ||:.|. .|:.......:|    ...|||:....||..
Zfish   230 FTVSQPKA-------LQEEGEDLQS--CLICIA-CQIPRPPQIPVS----TESFITKQDPTGKII 280

  Fly   297 FVDQRVLNILGYTPTE-LLGKICYDFFHPE--DQSHMKESFDQVLKQKGQMFSLLYRARAKNSEY 358
            .::...|...|....| |:.|..|.||.|:  :.||.|:...:|:.. |...|.||.....:...
Zfish   281 SIETSALRATGRPGWEDLVRKCIYAFFQPQGNEPSHAKKLLHEVMTH-GMAISPLYHFTLSDGTS 344

  Fly   359 VWLRTQAYAFLNPYTDEVEYIVC--------TNSSGKTMHGAP-LDAAAAHTPEQVQQQQQQEQH 414
            :..:|:. .|..|...:|:..:.        .|::....:..| |.:.||........|...:..
Zfish   345 LSAQTRC-KFCCPQNPDVQPFIMGFHTIDREHNTASSQENTTPSLSSPAAPPSRSPALQPSSDLS 408

  Fly   415 VYVQAAPGVDYARRELTPVGSATNDGMYQTHMLAMQAPTPQQQQQQQQRPGSAQTTPVGYTYDTT 479
            :::....|.           .||                          ||....||.||...:.
Zfish   409 IHLNNTNGT-----------CAT--------------------------PGPLTPTPPGYLTPSR 436

  Fly   480 HSP-YSAGGPSPLAKIPKSGTSPTPVAPNSWAALRPQQQQQ--QQQPVTEGYQYQQTSPA-RSPS 540
            ..| .....||||.       ||....|.|:.:.||.:...  ...|...|:.:..::|: .||:
Zfish   437 VGPSQQVSSPSPLG-------SPLTATPTSFMSPRPPRGSPGLASSPRVPGHPFSPSTPSIHSPA 494

  Fly   541 GPTYTQLSAGNG----------NRQQAQPGAYQAGPPP--PPNAPG---------------MWDW 578
            |....|.|.|:|          .||...|.:..|..||  ||.|..               :.|.
Zfish   495 GGLTRQQSGGDGVGFSLPSPLPPRQTPTPSSSPARQPPAKPPEASNDEPKSNQVGNPKLSQLLDG 559

  Fly   579 QQAGGHPHPPHPTAHPHHPHAH---------------PGGPAGAG-QPQ---------------- 611
            ..|......|.|:.....|.:|               ...||.|| :|.
Zfish   560 ASAPEQDSQPRPSPTSQCPASHSSLTERHKILHRLLQDNSPADAGKEPDIKKEPPTSPNSALIAR 624

  Fly   612 --GQEFSD--MLQ-MLDHTPTTFEDL 632
              |:|..|  :|: :||......|||
Zfish   625 GLGKEPQDHQLLRFLLDTDEKDLEDL 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	17/62 (27%)
		PAS	87..192	CDD:279347	35/112 (31%)
		PAS	90..154	CDD:214512	25/70 (36%)
		PAS_11	283..384	CDD:291273	26/111 (23%)
		PAS	283..380	CDD:238075	26/99 (26%)
ncoa1	XP_021324335.1	HLH	35..89	CDD:197674	17/53 (32%)
		PAS	121..178	CDD:214512	24/57 (42%)
		PAS_11	267..376	CDD:317051	26/110 (24%)
		Atrophin-1	<384..670	CDD:331285	64/311 (21%)
		Nuc_rec_co-act	869..913	CDD:312376
		DUF1518	1150..1206	CDD:311422
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900