DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tgo and ARNTL

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	XP_016873227.1	Gene:	ARNTL / 406	HGNCID:	701	Length:	674	Species:	Homo sapiens

Alignment Length:	549	Identity:	203/549 - (36%)
Similarity:	299/549 - (54%)	Gaps:	74/549 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRGTGNTSSDGTY 78
            :||.|.:||:|||:||.::|.||:.:||||:|::||.||||:|||||.|||.|||..|..::..|
Human   116 AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANY 180

  Fly    79 KPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHIHPDDRE 143
            ||:||:|.|||||||.|||||||||.||.|::::||:||..:|||:|:|..|.||::::||.|..
Human   181 KPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIA 245

  Fly   144 KIREQLSTQESQNAGRILDLKSG-TVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESMVSGHLN 207
            |::||||:.::....|::|.|:| .||.:......||..||||.|.|||:             .|
Human   246 KVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK-------------CN 297

  Fly   208 R--LKQRNSLGPS------RDGTNYAVVHCTGYIKNWPPTDMFPNMHMERDVDDMSSHC---CLV 261
            |  :|..:...||      .|..::..:|.|||:|:||||    .|.::.|.:..:..|   |||
Human   298 RPSVKVEDKDFPSTCSKKKADRKSFCTIHSTGYLKSWPPT----KMGLDEDNEPDNEGCNLSCLV 358

  Fly   262 AIGRLQVTSTAANDMSGS--NNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFHP 324
            |||||. :......::|.  ....|:::|||:||||.|||||...||.|.|.||||..||::||.
Human   359 AIGRLH-SHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQ 422

  Fly   325 EDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNS--SGK 387
            :|..|:.|...|||:.:.::.:..|:.:.|:..::.||::.::|:||:|.||||||.||:  ...
Human   423 DDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLAN 487

  Fly   388 TMHGA----PLDAAAAHTPEQVQQQQQ--------QEQHVYVQAAPGVDYARRELTPVGSATNDG 440
            .:.|.    |...|:.|:.:.:....:        :..|..|...||  ..|.....:|....:.
Human   488 VLEGGDPTFPQLTASPHSMDSMLPSGEDSFVVGGPKRTHPTVPGIPG--GTRAGAGKIGRMIAEE 550

  Fly   441 MYQTHMLAMQAPTPQQQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGGPSPLAKIPKSGTSPTPVA 505
            :.:.|.:            :...|.|..::|:..|........|.||    .||...|   ||..
Human   551 IMEIHRI------------RGSSPSSCGSSPLNITSTPPPDASSPGG----KKILNGG---TPDI 596

  Fly   506 PNSWAALRPQQQQQQQQPVTEGYQYQQTS 534
            |:|...    ..|.|:.|   ||.|..:|
Human   597 PSSGLL----SGQAQENP---GYPYSDSS 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	32/51 (63%)
		PAS	87..192	CDD:279347	54/105 (51%)
		PAS	90..154	CDD:214512	36/63 (57%)
		PAS_11	283..384	CDD:291273	46/100 (46%)
		PAS	283..380	CDD:238075	43/96 (45%)
ARNTL	XP_016873227.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144510
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750