DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tgo and ARNT

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_001659.1	Gene:	ARNT / 405	HGNCID:	700	Length:	789	Species:	Homo sapiens

Alignment Length:	734	Identity:	325/734 - (44%)
Similarity:	415/734 - (56%)	Gaps:	119/734 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEANIQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKAL 66
            ||.:..||||.| ||||.|||||||||||||||||||||||||||||||||||||||||:|||:|
Human    79 DEQSSADKERLA-RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSL 142

  Fly    67 RGTGNTSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGT 131
            |||||||:||:||||||||||||||||||||||||:|||::|||:|||||||||||..||:|:|:
Human   143 RGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGS 207

  Fly   132 SLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVG-- 194
            :||:.:||||.:|:||||||.|:...|||||||:|||||||.|||||:.||:||.||||||.|
Human   208 TLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSS 272

  Fly   195 NVNPESMVSGHLNRL-----KQRNSLGPSRDG-TNYAVVHCTGYIKNWPPTDM-FPNMHMERDVD 252
            :|:|.|     :|||     :.||.||..:|| .::.|||||||||.|||..: .|:       |
Human   273 SVDPVS-----VNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPD-------D 325

  Fly   253 D----MSSHCCLVAIGRLQVTSTA-ANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTE 312
            |    ..|..||||||||||||:. ..|||.....:|||:||.::|.|||||.|.:..:||.|.|
Human   326 DPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQE 390

  Fly   313 LLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVE 377
            ||||...:|.|||||..:::||.||:|.|||:.|:::|.|:||.|::|:||.::.|.|||:||:|
Human   391 LLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIE 455

  Fly   378 YIVCTNSSGKTMHGAPLDAAA-----------AHTPEQVQQQQ----QQEQHVYVQAAPGVD--- 424
            ||:|||::.|.....|....:           |:.|.::...|    ||:|...:...||.|
Human   456 YIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLA 520

  Fly   425 -YARRE----LTPVGSATNDGMYQTHMLAMQAPTPQQQQ------QQQQRPGSAQTTPV------ 472
             |...:    :|..|...:..:.::..|..|...|:..:      ..|.:..|:.|.|.
Human   521 SYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFS 585

  Fly   473 -GYTYDTTHSPY-----------------SAGGPSPLAKI-----PKSGTSPTPVAPNSWAALRP 514
             |.|:..|..|.                 ||.....||:|     |..|.:|| ..|.:.:....
Human   586 QGNTFPPTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPT-WTPTTRSGFSA 649

  Fly   515 QQQQQQQQPVTEGYQYQ----QT-----------SPARSPSGPTYTQLSAGNGNRQQAQPGAYQA 564
            ||...|....|...|:.    ||           :|..||....|..|:  |.....|......|
Human   650 QQVATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLT--NRGSNFAPETGQTA 712

  Fly   565 GPPPPPNAPGMWDWQQ-AGGHPHPPHPTAHPH---HPHAHPGGPAGAGQPQGQEFSDMLQMLDHT 625
            |......|.|:..|.| .|..||....::..|   .|...||.|        :.|.:||.||...
Human   713 GQFQTRTAEGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQP--------EVFQEMLSMLGDQ 769

  Fly   626 PTTF---EDLNINMFSTPF 641
            ..::   |..::.|| .||
Human   770 SNSYNNEEFPDLTMF-PPF 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	48/51 (94%)
		PAS	87..192	CDD:279347	77/104 (74%)
		PAS	90..154	CDD:214512	46/63 (73%)
		PAS_11	283..384	CDD:291273	54/100 (54%)
		PAS	283..380	CDD:238075	51/96 (53%)
ARNT	NP_001659.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97		11/18 (61%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:28396409	88..128		37/40 (93%)
		HLH	91..143	CDD:278439	48/51 (94%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000250\|UniProtKB:P53762	112..264		120/151 (79%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000250\|UniProtKB:P53762	112..168		51/55 (93%)
		PAS	163..269	CDD:279347	78/105 (74%)
		PAS	166..230	CDD:214512	46/63 (73%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250\|UniProtKB:P53762	167..171		3/3 (100%)
		PAS_11	362..462	CDD:291273	54/99 (55%)
		PAS	362..458	CDD:238075	51/95 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..492		3/26 (12%)
		Med3	<523..>734	CDD:288447	44/213 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..789		32/127 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144509
Domainoid	1	1.000	166	1.000	Domainoid score	I3894
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1374
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	1	1.000	-	-		otm40426
orthoMCL	1	0.900	-	-		OOG6_105223
Panther	1	1.100	-	-	LDO	PTHR23042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2390
SonicParanoid	1	1.000	-	-		X1928
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790